Alzheimer's disease. Flashcards
1
Q
what does AD affect in the brain
A
it affects the hippocampus and around it. the cholinergic is affected.
2
Q
the two features of AD is
amyloid plaques and neurofibrillary tangles
A
the amyloid plaques trigger an inflammatory response
the neurofib tangles is an innapropriate phosphoralation of proteins inside neuron
3
Q
is it better to have beta amyloid 40 or 42 ?
A
long form is bad. our own inflammation to b amyloid is what’s causing the symptoms.
4
Q
some genetic causes of AD
A
APP gene on chromosome 21
y-secretase affect chromosom 1 and 14
Apoliprotein E4
5
Q
other causes of AD (not genetics)
A
impacts
sporadic.
6
Q
treatment
A
choline : toxic environment.
