Neurodegenerative Diseases Flashcards
how to DC DMARDs with MLF
you must employ MLF for at least 12 months with good
effect before even attempting to gradually transition to less potent
immune suppressive drug therapy.
Melatonin and AD
Improves sleep,
decreases sundowning
slows prog of cognitive impairment
dec beta amyloid
light exposure and neurodeg
•↓ morning light exposure is associated with poorer sleep
quality
IL-10 and exercise
exercise x 6 mo improves IL 10 and sleep
MS and food triggers
linked to dairy intake (milk)
food triggers and SCZ
higher IgG food sens to gluten and casein
Mushrooms effects
Activate NK cells
Prime immune system
dec cog decline
dec depression
Vit K found in
greens
Vit K2 effects
Ca into bones/teeth
neural stem cells and myelin production
MCT based keto diet
can have more carbs than olive oil (60-80kcal/day) but check fasting lipids!
smoking and neurodeg
higher risk
statins and neurodeg
block remyelination
DM + ApoE4 and AD
synergistic (5x increase)
How to increase BDNF in neurodegenerative pts?
exercise
mushrooms
fasting/ketosis/ metabolic switching.
TBI and neurodeg
increases risk of all!