Neurodegenerative conditions

Question 1

Features of Parkinson’s disease

Answer 1

Rigidity (Stiff)

• Shuffling gait
• Cogwheel rigidity
• Hypertonia
• Minimal facial expressions

Resting tremor (Shaky)
- Pill-rolling

Bradykinesia (Slow)

• Slow speech
• Micrographia

Disturbed autonomic function

• Sleep disturbances
• Orthostatic hypotension
• Urinary retention
• Bradycardia

Question 2

The tremor in Parkinson’s disease is of what frequency?

Answer 2

4-6 Hz

Question 3

What other things can mimic Parkinson’s disease

Answer 3

Medication

• Antipsychotics
• Dopamine antagonists (i.e. antiemeitcs)

Dementia with Lewy Body

Multiple system atrophy

Question 4

First line dopamine replacement for Parkinson’s disease is…

Answer 4

L-Dopa

- With peripheral decarboxylase inhibitors (i.e. carbidopa)

Question 5

_______ is a monoamine inhibitor that prevents dopamine breakdown and can be used in Parkinson’s disease.

Answer 5

Selegiline

Question 6

First line medication for Alzheimer’s

Answer 6

Acetylcholinesterase inhibitors

• Rivastigmine
• Donepezil

Question 7

Second line medication for Alzheimer’s

Answer 7

If intolerant to acetylcholinesterase inhibitors

- Memantine