Neurocritical care and drugs Flashcards

1
Q

How does labetalol work?

A

selective alpha blocker, beta non-selective

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2
Q

What is thiopental?

A

short acting barbiturate

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3
Q

How do NSAIDS work?

A

Inhibiting COX - cyclooxygenase - Which participates in the synthesis of prostaglandins and thromboxanes

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4
Q

What is different about aspirin compared to other NSAIDs in its interaction with cyclooxygenase?

A

aspirin binds irreversibly - which is why you have to wait 8-10 days for it’s anti-platelet function to wear off

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5
Q

What is the Cockroft gault equation?

A

how to work out creatinine clearance

[140-age] x ideal weight / 72 x serum creatinine (x.85 in females)

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6
Q

How does tramadol work?

A

Weak opioid - binds to mu-receptors and inhibits re-uptake centrally of norad and serotonin

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7
Q

What is tryptophan?

A

serotonin pre-cursor

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