Endocrinology Flashcards

1
Q

What is Schmidt syndrome?

A

Autoimmune hypothyroidism + autoimmune hypocortisolism (Addisons) +/- type 1 diabetes

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2
Q

Where does the anterior pituitary develop from?

A

Evagination of the epithelial ectoderm from the oropharynx this evagination is rathke’s pouch which is eventually separated from oropharynx by sphenoid bone -

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3
Q

What is proopiomelanocortin and where is it predominantly synthesised?

A

Precursor of ACTH and alpha-MSH

Predominantly produced in anterior pituitary (but also found in hypothalamus)

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4
Q

Which hormone released by the anterior pituitary is under inhibitory control by the hypothalamus?

A

Prolactin (main inhibitory factor is Dopamine).

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5
Q

Where is IGF-1 released from?

A

Liver - IGF-1 carries out the majority of the effects of GH.

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6
Q

What hormones control the release and synthesis of GH? What hormone inhibits GH release?

A

GHRH (from arcuate nucleus) - synthesis and release
Somatostatin (from periventricular nucleus) - inhibits release only

Ghrelin - stimulates release of GH.

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7
Q

Which hormones release are inhibited by somatostatin?

A

GH

TRH

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