Haematology Flashcards

1
Q

Define massive transfusion

A

replacement of >1 blood volume (av 20 units) in <24 hours

or >2 x circulating volume in paeds

Components PRBC, Plt, FFP

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2
Q

What is the circulating volume of blood in neonates?

A

80-90ml/kg

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3
Q

When would you transfuse PRBC?

A
  1. acute blood loss (15% TBV)
  2. asymptomatic but Hb <8
  3. Symptoms of anaemia at rest
  4. in neonates if preop Hb<15g/dl
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4
Q

What antibodies would be present in type AB blood?

A

none - which is why they can take all other blood type donors

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5
Q

Reversal agent for dabigatran?

A

praxbind (idarucizumab)

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6
Q

When would you used FFP or PCC?

A

Emergency reversal of warfarin

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7
Q

How does enoxaparin work?

A

Binds and accelerates function of antithrombin III. Inhibits thrombin and factor Xa

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8
Q

How does aspirin work?

A

irreversible COX-1 inhibitor

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