Neurocognitive Disorders Flashcards
Delirium criteria
- Disturbance in attention and awareness over short time
- 1+ other cognitive disturbance (language, memory, etc.)
- Symptoms connected to medical cause
Delirium course
- Develops in hours to a few days
- Change from baseline
- Fluctuates in severity throughout day
Risk factors for delirium
- Hospitalized older adults
- High fever
- Nutritional deficiency
- Electrolyte disturbance
- Renal or hepatitic failure
- Head injury
- Drugs/medications
Common substance/medication sources of Delirium
- Alcohol
- Lithium
- Sedatives
- Anticholinergic drugs
Delirium treatment
- Addressing medical problem
- Environmental changes (reduce disorientation)
- Antipsychotics (agitation, psychotic symptoms)
NCDs
- Acquired (NOT developmental) cognitive dysfunction
- Mild or major
Mild NCD criteria
- Modest decline from baseline in 1+ cognitive areas
- Not just part of Delirium
- Independence w/ skills
Major NCD criteria
- Significant decline from baseline in 1+ cognitive areas
- Not just part of Delirium
- No independence
Types of NCDs
- NCD due to Alzheimer’s
- NCD with Lewy Bodies
- Vascular NCD
- NCD due to HIV Infection
- NCD due to Prion Disease
- Frontotemporal NCD
- NCD due to Another Medical Condition
NCD due to Alzheimer’s Disease criteria
- Meet criteria for mild or major NCD
- 1+ areas for mild, 2+ areas for major
- Subtle onset, slow progression
- Probable for Alzheimer’s
- Not better explained
Mild NCD + possible Alzheimer’s
- No genetic mutation
- Decline in memory and learning
- Gradual
- No mixed etiology
Mild NCD + probable Alzheimer’s
- Genetic mutation
Major NCD + possible Alzheimer’s
- Criteria for Major NCD + probable Alzheimer’s not fully met
Major NCD + probable Alzheimer’s
- Genetic mutation
- Decline in memory and one other area
- Gradual
- No mixed etiology
NCD due to Alzheimer’s prevalence
- Women > men (may be due to life expectancy)
- 65+ yo
- Black Americans
NCD due to Alzheimer’s course
- Onset 70-89 yo
- When onset 49-59 yo = genetic mutation
Diagnosing NCD due to Alzheimer’s
- ONLY confirmed by brain biopsy (high risk) or autopsy
- Symptoms + ruling out other causes
- Family history
- Exams (physical, neuro, neuropsych, status)
- Labs, scans (MRI, CT)
NCD due to Alzheimer’s genetic mutation
ApoE4 chromosomal variant
NCD due to Alzheimer’s and brain structure
- General = buildup of proteins
- Amyloid plaques (beta-amyloid clumps)
- Neurofibrillary tangles
- Mild = rapid loss of smell
Locus coeruleus (in brain stem)? >
Medial temporal lobe >
Frontal and parietal lobes >
Entire cortex
Amyloid plaques
- Linked to NCD due to Alzheimer’s
- Beta-amyloid protein clumps
Neurofibrillary tangles
- Linked to NCD due to Alzheimer’s
- Disrupt between-cell communication
- Tau protein
- Threads > tangles
NCD due to Alzheimer’s risk factors
- Low educational status
- Obesity
- Hearing loss
- Down’s syndrome
- High neuroticism, low conscientiousness
NCD due to Alzheimer’s and Down’s syndrome
- Extra chromosome for amyloid protein
- Early onset in 20s
MCD due to Alzheimer’s and Big Five
- High neuroticism AND low conscientiousness
- More amyloid and tau proteins
Alzheimer’s course
- Duration = 8-10 years
- Early, middle, and late stages
Early stage of Alzheimer’s
2-4 years
- ST memory loss
- Anomia
- Personality changes
- Anxiety, depression
- Impaired attention and concentration
- Poor judgement
- Disorientation
Middle stage of Alzheimer’s
2-10 years
Worsens:
1. Memory (ST worse and new LT loss)
2. Disorientation
3. Mood (anxiety, depression > labile, irritable)
New:
1. Psychotic symptoms
2. Behavior (wandering, pacing, repetitive, impulsive)
3. Speech (poor, repetitive)
4. Basic needs (sleep, adaptive skills)
5. “Sundowning”
Late stage of Alzheimer’s
1-3 years
Worsens:
1. Cognitive functioning
2. Disorientation
3. Mood (labile, irritable > apathy, agitation, aggression)
4. Speech
4. Basic needs (appetite, incontinence, motor skills, self-care)
New:
5. Health (abnormal reflexes, infections, seizures)
Pseudodementia
- Depression w/ cognitive symptoms that mask as Alzheimer’s symptoms due to denial of depressive symptoms
- Responds well to treatment
Pseudodementia v. Alzheimer’s
- Abrupt onset of cognitive symptoms (Alzheimer’s = gradual)
- Exaggerated cognitive problems
(Alzheimer’s = deny cognitive problems) - Moderate memory loss
(Alzheimer’s = severe memory loss) - Melancholia and anxiety
(Alzheimer’s = apathy and avolition) - Often says “I don’t know” to questions
(Alzheimer’s = often answers incorrectly)
Alzheimer’s treatment
No cure (focused on symptom reduction)
Better outcomes at home v. facility
- Medications
- Cognitive-behavioral interventions
- Support, caregivers, etc.
- Skills training
Medications for Alzheimer’s
- Cholinesterase inhibitors = reduce cognitive symptoms
- NMDA receptor antagonist = regulate glutamate (memantine)
- Antidepressants = depression, irritability
- Anxiolyics = anxiety, restlessness
- Antipsychotics = mania, psychosis, risky behavior
Cholinesterase inhibitors for Alzheimer’s
- Donepezil
- Rivastigmine
NCD with Lewy Bodies criteria
- Meet criteria for mild or major NCD
- Meet criteria for possible or probable NCD
Possible NCD with Lewy Bodies
1 core feature
OR
2 suggestive features
Probable NCD with Lewy Bodies
2 core features
OR
1 core + 1 suggestive feature
NCD with Lewy Bodies CORE symptoms
- Fluctuating cognition (attention, alertness)
- Recurrent visual hallucinations
- Parkinson’s symptoms (WITH or AFTER cognitive symptoms)
NCD with Lewy Bodies SUGGESTIVE symptoms
- REM sleep behavior disorder
- Severe neuroleptic sensitivity
Alzheimer’s v. Lewy Bodies
Early cognitive deficits:
1. Alzheimer’s = learning, memory
2. Lewy Bodies = complex attention, visuospatial ability, executive function
Vascular NCD criteria
- Meet criteria for mild or major NCD
- Vascular etiology (stroke, cerebrovascular event) or decline in attention and executive function
- Evidence of cerebrovascular disease
Vascular NCD course
Depends on etiology
- Acute w/ partial recovery
- Stepwise decline
- Progressive w/ fluctuations and plateaus
Vascular NCD treatment
- Prevention and intervention of causes/risk factors
Vascular NCD risk factors
- Hypertension
- Heart disease
- Diabetes
- Obesity
- High cholesterol
- Smoking
NCD due to HIV Infection criteria
- Meets criteria for mild or major NCD
- Infection with HIV
NCD due to HIV Infection symptoms
- Forgetfulness
- Impaired attention
- Cognitive slowing
- Psychomotor retardation
- Clumsiness/tremors
- Apathy
- Social withdrawal
NCD due to Prion Disease criteria
- Meet criteria for mild or major NCD
- Insidious onset, rapid progression (mild to major NCD in < 6 months)
- Motor or biomarker (lesions) features of prion disease
Prion Disease v. Alzheimer’s
- Rapid progression
(Alzheimer’s = gradual progression)
Creutzfeldt-Jakob Disease (CJD)
- Most common prion disease
- Four types
Four types of CJD (and etiology)
- Sporadic CJD* (unknown)
- Familial CJD (inherited)
- Acquired CJD (infected meat, transmission via blood transfusion)
- Iatrogenic CJD (transmission via medical procedures)
CJD symptoms
- Confusion, disorientation
- Impaired memory and judgment
- Motor (ataxia, myoclonus, chorea)
- Psychiatric (apathy, anxiety, mood swings)
Most common NCDs
- Overall = Alzheimer’s (60-80%)
- Early-onset < 65 yo = Frontotemporal NCD
Frontotemporal NCD criteria
- Meet criteria for mild or major NCD
- Insidious onset, gradual progression
- No significant impact on learning, memory, motor skills in early stages
- Meet criteria for behavioral (common) or language variant
Behavioral Frontotemporal NCD criteria
- Decline in social cognition and/or executive function
- 3+ other symptoms
Behavioral Frontotemporal NCD symptoms
- Behavioral disinhibition
- Apathy and inertia
- Loss of sympathy or empathy
- Stereotypy or compulsions
- Dietary changes
Language Frontotemporal NCD
- AKA Primary Progressive Aphasia (PPA)
- Three types
Three types of Language Frontotemporal NCD
- Semantic PPA = impaired comprehension of written and spoken language
- Agrammatic/nonfluent PPA = incorrect grammar and effortful speech
- Logopenic PPA = repetition of phrases, word-finding difficulty
NCD due to Another Medical Condition
- Meet criteria for mild or major NCD and evidence that symptoms related to medical condition
- Depends on underlying condition = onset, progression, treatment, prognosis
Potentially reversible NCD medical conditions
- Hypoxia
- Infections
- Endocrine disorders
- Poisoning
- Nutritional deficiences