Nervous System, Neurons, and Neurotransmitters Flashcards

1
Q

Nervous system breakdown

A

Nervous system:
1. Central nervous system (CNS)
2. Peripheral nervous system (PNS)

PNS:
1. Somatic nervous system (SNS)
2. Autonomic nervous system (ANS)

ANS:
1. Sympathetic nervous system
2. Parasympathetic nervous system

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2
Q

Central nervous system (CNS)

A

Brain and spinal cord

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3
Q

Peripheral nervous system (PNS)

A

Signals between the CNS and rest of the body

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4
Q

Somatic nervous system (SNS)

A
  1. Signals between CNS and skeletal muscles
  2. Voluntary actions
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5
Q

Autonomic nervous system (ANS)

A
  1. Signals between CNS and smooth muscles, organs
  2. Involuntary actions (unless learned to control through biofeedback)
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6
Q

Sympathetic nervous system

A
  1. Prepares body for action (fight-or-flight)
  2. Can cause rapid physiological changes
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7
Q

Fight-or-flight physiological changes

A
  1. Pupil dilation
  2. Sweating
  3. Increased heart rate
  4. Increased respiration rate
  5. Inhibited digestion
  6. Inhibited sexual activity
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8
Q

Parasympathetic nervous system

A
  1. Returns body to resting state (after fight-or-flight)
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9
Q

Two types of cells in nervous system

A
  1. Neurons
  2. Glia
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10
Q

Neurons function

A

Communicates information within nervous system

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11
Q

Glia function

A

Provides neurons with structural support, insulation, and nutrients

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12
Q

Neuron structural components

A
  1. Dendrites - receives information
  2. Soma (cell body) - contains classic cell parts (nucleus, mitochondria, etc.)
  3. Axon - transmits information
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13
Q

Myelin

A
  1. Produced by glia
  2. Insulates some neuron axons
  3. Speeds up conduction between neurons
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14
Q

Two processes driving communication in CNS

A
  1. Conduction
  2. Transmission
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15
Q

Conduction in the CNS

A

Electrochemical process:

Cell rests (negatively charged)
>
Dendrites stimulated
>
Cell membrane channels open
>
Sodium ions enter
>
Cell depolarized (less negative)
>
Action potential triggered

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16
Q

Action potential

A
  1. Electrical impulse
  2. All-or-none responses (intensity of a stimulus not based on action potential intensity but number of action potentials)
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17
Q

Transmission in the CNS

A

Typically chemical process (AKA synaptic transmission):

Action potential reaches axon terminal >
Neurotransmitter released to synaptic cleft
>
Neurotransmitter produces effect on postsynaptic neuron
>
Neurotransmitter inactivated

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18
Q

Neurotransmitter inactivation

A
  1. Can be reabsorbed into presynaptic neuron
  2. Can be broken down by enzymes
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19
Q

Neuroplasticity

A

The brain’s ability to change in structure and function throughout development and in response to life experiences

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20
Q

Four types of neuroplasticity

A
  1. Homologous area adaptation
  2. Cross-modal reassignment
  3. Map expansion
  4. Compensatory masquerade
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21
Q

Homologous area adaptation

A

If brain area damaged early, functions shift to corresponding area in opposite hemisphere, can lead to less function in corresponding area

e.g., left parietal lobe takes over for damaged right parietal lobe

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22
Q

Cross-modal reassignment

A

If sensory brain area deprived of stimuli, function in that area changes

e.g., blindness leads to “somatosensory input” (visualizing mentally) in that area

23
Q

Map expansion

A

Temporary or permanent enlargement of a cortical area, usually when learning a new skill

e.g., practicing an instrument

24
Q

Compensatory masquerade

A

If brain area damaged, person will use another brain area with function that compensates for lost function

e.g., using memory of landmarks to compensate for loss of visuospatial ability

25
Two types of neurotransmitters
1. Small-molecule neurotransmitters 2. Neuropeptides Based on size and synthesis
26
Small-molecule neurotransmitters
1. Smaller 2. Synthesized and stored in axon terminal
27
Neuropeptides
1. Larger 2. Synthesized in cell body and transmitted to axon terminal
28
Two types of neuropeptides
1. Enkephalin 2. Endorphin Both endogenous opioids with analgesic and euphoric effects
29
Dopamine
1. Excitatory or inhibitory 2. Movement, personality, mood, sleep
30
Parkinson's and dopamine
Low dopamine in substantia nigra
31
Tourette's and dopamine
High dopamine in caudate nucleus
32
Schizophrenia and dopamine
High dopamine activity (according to dopamine hypothesis)
33
Four types of dopaminergic pathways
1. Mesolimbic 2. Mesocortical 3. Tuberoinfundibular 4. Nigrostriatal
34
Mesolimbic dopaminergic pathway
1. Begins in ventral tegmental area (evidence that dorsolateral prefrontal cortex signals motivation for reward) 2. Ends in ventral striatum (nucleus accumbent) 3. Reward circuit (e.g., substance use)
35
Mesocortical dopaminergic pathway
1. Begins in ventral tegmental area 2. Ends in prefrontal cortex 3. Emotion, motivation, executive function
36
Tuberoinfundibular dopaminergic pathway
1. Begins in hypothalamus 2. Ends in pituitary gland 3. Hormone regulation, inhibits prolactin
37
Nigrostriatal dopaminergic pathway
1. Begins in substantia nigra 2. Ends in dorsal striatum (caudate nucleus and putamen) 3. Purposeful movement
38
Acetylcholine
1. Excitatory or inhibitory 2. Movement (muscle contraction), arousal, attention, memory
39
Myasthenia gravis
Autoimmune disorder Muscle weakness due to destruction of acetylcholine receptors at neuromuscular junctions
40
Acetylcholine and Alzheimer's
Low acetylcholine in entorhinal cortex and hippocampus related to early memory loss
41
Glutamate
1. Excitatory 2. Movement, emotions, learning, memory
42
Glutamate-induced excitotoxicity
Excessive glutamate Can cause cell damage and death Linked to stroke, seizures, neurogenerative disorders (Huntington's, Alzheimer's)
43
Norepinephrine
1. Excitatory 2. Arousal, attention, learning, memory, stress, mood
44
Norepinephrine and mood
1. Low norepinephrine = depression (based on catecholamine hypothesis) 2. High norepinephrine = mania
45
Serotonin
1. AKA 5-HT 2. Inhibitory 3. Arousal, sleep, sexual activity, mood, appetite, pain
46
Serotonin and related disorders
Low serotonin: 1. Depression 2. Suicide 3. Bulimia 4. OCD 5. Migraines High serotonin: 1. Anorexia 2. ASD 3. Chronic schizophrenia w/ large ventricles and/or cerebral atrophy
47
Gamma-aminobutyric acid (GABA)
1. Inhibitory 2. Memory, mood, arousal, sleep, motor control
48
GABA and related disorders
Low GABA: 1. Insomnia 2. Seizures 3. Anxiety 4. Huntington's
49
GABA and Huntington's disease
Degeneration of GABA and acetylcholine cells in basal ganglia contribute to motor symptoms
50
Psychoactive drug classes
1. Agonists 2. Partial agonists 3. Inverse agonists 4. Antagonists
51
Agonists
Mimic or increase effects of neurotransmitter Direct = increase neurotransmitter by binding to receptor site and acting as the neurotransmitter Indirect = increase neurotransmitter without binding to receptor site
52
Partial agonists
Produce similar but weaker effects than neurotransmitter/agonist
53
Inverse agonists
Produce opposite effects to neurotransmitter/agonist
54
Antagonists
Block or reduce effects of neurotransmitter/agonist Direct = A