Neurochemistry of Memory Flashcards
This part of the brain is responsible for emotional responses
Amygdala
Part of the brain involved in declarartive (explicit) memory
Hippocampus
Medial temporal lobe
Diencephalon
Affects mood, hunger, sleep and arousal
Serotonin
Influences movement, learning, attention and emotional
Dopamine
Undersupply linked to depression
Serotonin
Noradrenaline
Oversupply linked to schizophrenia
Dopamine
Undersupply linked to tremors and decreased mobility in Parkinsons
Dopamine
Undersupply linked to ADHD
Dopamine
Noradrenaline
Neurotransmitter that enables muscle action, learning and memory
Acetylcholine
Which neurones deteriorate as Alzheimer’s disease progresses?
ACh-producing neurones
Helps control alertness and arousal
NA
Undersupply can depress mood and cause ADHD-like problems
NA
Undersupply linked to seizures, tremors and insomnia
GABA (bc its inhibitory so not enough = your body is super excited)
Oversupply can stimulate the brain producing migraines or seizures
Glutamate (why some people avoid MSG foods haha)
Most frequent neurotransmitter in the CNS
Glutamate
Which channels does ACh work on and how?
Inhibits nicotinic ion channels by depolarisation
Key role in memory, attention and arousal
ACh
Which receptors does glutamate work on?
AMPA
Metabotropic
NMDA
This is involved in post-synaptic long term potentiation
Glutamate
These receptors produce rapid responses to glutamate
AMPA
These receptors are responsible for synaptic plasticity and are key in long term potentiation
-how do they work?
NMDA
-allow Calcium influx
(glutamate responsible for this)
(AMPA also play a role)
Agonists reduce or prevent neuro inflammation and modualte mitochondrial function
PPARy
Role of ApoE
Cholesterol metabolism
Membrane stability and repair
-problems with this gene in alzheimers
Role of tau protein
Stabilises microtubules
Purpose of striatal interneurones
Motor control
Purpose of the nucelus basalis of Meynert?
Attention/arousal
Purpose of medial septal nucleus?
Learning and memory
Alzheimers meds/ drugs which prevent ACh breakdown?
Galantamine
Rivestigmine
Donepezil
