Neurobiology of psychosis II

Question 1

Viral illness in which trimester could cause schizophrenia?

Answer 1

2nd trimester

Question 2

Risk of schizophrenia if you have a childhood CNS infection?

Answer 2

Risk increased by 50%

Question 3

Frontal lobe and ventricle changes in schizophrenia?

Answer 3

Reduced frontal lobe volume
Reduced frontal lobe grey matter
Enlarged lateral ventricles

Question 4

Ppl with schizophrenia show consistent reductions in which part of the brain?

Answer 4

Temporal cortex

Medial temporal lobe

Question 5

What does a high FA mean? (functional anisotropy)

Answer 5

Higher numbers = healthy white matter tracts

-but higher FA correlated with psychotic symptom severity

Question 6

What does a high MD mean? (mean diffusivity)

Answer 6

Higher numbers = less healthy white tracts

Question 7

What do D1 receptors do?

Answer 7

Stimulate cAMP

Question 8

What do D2,3,4 receptors do?

Answer 8

Inhibit adenyl cyclase
Inhibit voltage activated Ca2+ channels
Open K+ channels

Question 9

A signalling protein that mediates cell-cellinteractions and plays critical roles in the growth and development of multiple organ systems

Answer 9

Neuregulin

Question 10

Essential for adaptive neural plasticity

Answer 10

Dysbindin

Question 11

Involved in neurite outgrowth and cortical development through its interaction with other proteins

Answer 11

DISC-1

Question 12

Serotonin to D2 ratio in atypical antipsychotics

Answer 12

High 5-HT2A to D2 ratio

Question 13

Definition of atypical antipsychotics?

Answer 13

Less likely to cause atypical symptoms