Neurobiology of dementias and clinical aspects Flashcards
Dementia
Cognitive impairment
Progressive
Multi-domain
Affects life
Due to brain disease
Occurring in an adult
Cognitive impairment
Memory
Language
Executive
Social
Visuospatial
What causes dementia?
Brain dysfunction
Brain damage
Neurodegeneration
Brain dysfunction
Thyroid
Sodium
Drugs
Depression
Poor sleep
Pain
Brain damage
Vascular disease
Multiple sclerosis
Alcohol
Tumour
Neurodegeneration
Alzheimer’s
Lewy body disease
Problem’s with memory
Encoding: many causes
Consolidation: Alzheimer’s, alcohol, brain injury
Recall: many causes
Alcohol and thiamine
Deficiency leads to Wernicke’s Korsakoff’s syndrome
Wernicke’s
Delerium
Ataxia
Eye movements
Korsakoff’s
Amnesia
Confabulation
Affects consolidation
Long term effects of alcohol
Attention
Speed
Ataxia
Seizures
Head injuries
Malnutrition
Liver disease
Other drugs
Dementia treatment
Depends on the cause
No disease modifying treatment for neurodegenerative dementias
Manage symptoms
