neurobiology of abnormal mood

Question 1

what genetic association has been found linked to abnormal mood

Answer 1

short allele of the serotonin transporter gene-linked polymorphic region, 5-HTTLPR

Question 2

appetitive/approach systems

Answer 2

function to mediate seeking and approach behaviours
-ascending dopamine systems
-ventral striatum
-dorsal striatum
-amygdala (conditioning/learning)
-anterior cingulate (attention/conflict/response selection)
-orbitofrontal cortex (relative reward preference/rule learning)

Question 3

aversive/defensive systems

Answer 3

function to promote survival in event of threat
-ascending serotonin systems
-NA/CRF/peptide transmitters
-central nucleus of amygdala
-hippocampus
-ventroanterior and medial hypothalamus
-periaqueductal grey matter

Question 4

brain regions implicated in mood disorders

Answer 4

-orbital frontal cortex
-ventromedial prefrontal cortex
-dorsolateral prefrontal cortex
-hippocampus
-amygdala
-anterior cingulate cortex