Neuroanatomy Exam 3 Flashcards
What do somatic sensory fibers convey?
Information from receptive endings for pain, temperature, and mechanical stimuli in somatic structures (skin, muscles)
What do visceral sensory fibers convey?
Information from receptive endings in visceral structures such as the walls of blood vessels
What are visceral motor fibers?
Preganglionic autonomic axons
What do somatic motor fibers innervate?
Skeletal muscle
Somatic motor fibers are the axons of…..
alpha and gamma motor neurons
How are cells concerned with visceral vs. somatic function arranged in the spinal gray matter?
Cells concerned with visceral function tend to be closer to the sulcus limitans (more medial). Cells concerned with somatic function tend to be more lateral.
What muscles develop from the pharyngeal arches?
Striated muscles in and near the head and neck
Which cranial nerves contain somatic motor fibers?
3, 4, 6, 11 and 12
What extraocular muscles does Cranial Nerve 3 (Occulomotor Nerve) innervate?
1) levator Palpebrae Superioris
2) Medial, superior and inferior recti
3) Inferior oblique
Where do fibers of cranial nerve 3 originate?
Occulomotor nucleus
Where is the occulomotor nucleus?
The anterior edge of the periaqueductal gray in the rostral midbrain
Describe the structure of the occulomotor nucleus. What does it consist of?
Consists of a series of longitudinal cell columns (referred to as subnuclei) that supply individual muscles
The coloumn of the occulomotor nucleus that supplies the superior rectus projects to….
The contralateral eye
The column of the occulomotor nucleus supplying the levator palpebrae superioris innervates this muscle….
Bilaterally
The columns of the occulomotor nucleus suppling the medial rectus, inferior oblique, and inferior rectus project to…..
The ipsilateral eye
What is the accessory occulomotor nucleus?
Also known as the Edinger-Westphal Nucleus, it is a column of the occulomotor nucleus containing preganglionic parasympathetic neurons
What does the accessory motor nucleus project to?
The ipsilateral ciliary ganglion
The ciliary ganglion innervate the…..
Pupillary sphincter and the ciliary muscle
What is lateral strabismus?
Damage to one occulomotor nerve. The eye ipsilateral to the lesion deviates laterally.
In lateral strabismus, what muscles are affected?
The medial rectus is paralyzed and the lateral rectus operates unopposed. The superior and inferior recti and inferior oblique are also paralyzed (prevents vertical movement)
Diplopia and being unable to move your eye laterally are clinical signs of…..
Lateral Strabismus
T/F The ipsilateral levator palpebrae superioris is paralyzed in lateral strabismus
True (results in ptosis)
T/F The pupillary sphincter and ciliary muscle remain functional in lateral strabismus
False, they become non-functional (ipsilateral effect)
In lateral strabismus, the pupil on the affected side is (dialted/undialated) as a result of the now-unopposed pupillary dialator, and it (does/does not) constrict in response to light
1) Dialated
2) Does not
What is usually the first clinically detectable sign of something pressing on the third nerve?
A dialated pupil unresponsive to light
What extraoccular muscle does the trochlear nerve innervate?
The superior oblique
Where at the cell bodies of origin for the trochlear nerve located?
In the contralateral trochlear nucleus
The trochlear nucleus is located at the level of the (superior/inferior) colliculus
Inferior
Where do fibers leaving the trochlear nucleus decussate?
Pontomedullary Junction
What does the superior oblique muscle do?
Helps move the adducted eye downward (like when reading or walking down stairs). Also aid in eye intorsion
Lesions to the trochlear nerve result in…
An extorted eye, resulting in tilting of head away from the lesioned side to compensate
The abduscens nerve innervates the…..
Lateral Rectus
Where do the fibers of the abduscens nerve originate?
The ipsilateral abduscens nucleus
Where is the abduscens nucleus located?
In the caudal pons beneath the floor of the fourth ventricle
What is the internal genu of the facial nerve?
The place where the facial nerve vibers wrap around the abduscens nucleus
What is responsible for the facial colliculus?
The abduscens nucleus and the internal genu
Damage to the abduscens NERVE causes…
Medial strabismus
What is medial strabismus?
Affected eye deviates medially. Individual may move the affected eye from adducted position to midposition (but not past it)
Damage to the abduscens NUCLEUS results in….
Lateral Gaze Paralysis
What is lateral gaze paralysis?
Damage to abduscens nucleus cause an inability of the ipsilateral eye to abduct past midposition and the contralateral eye to adduct past its midposition
Why does damage to the abduscens nucleus cause lateral gaze paralysis?
The abduscens nucleus contains not only recuts motor neurons but also internuclear neurons with axons that ascend through the MLF to the CONTRALATERAL occulomotor nucleus.
The abduscens nucleus also contains interneurons that project to the….
contralateral occulomotor nucleus
Why is it important that the abduscens nucleus projects interneurons to the contralateral occulomotor nucleus?
This makes it possible to have both eyes look in the same direction. Looking in the same direction requires one lateral rectus and the contralateral medial rectus to contract simultaneously. Simultaneous firing of abduscens motor neurons and internuclear neurons allow for coordinated lateral gaze.
Damage to one MLF results in…..
the ipsilateral eye (to the lesion) failing to move past midposition during attempted horizontal gaze
The accessory nerve innervates….
Neck and shoulder muscles
The hypoglossal nerve innervates….
Tongue Muscles
Where do the fibers of the hypoglossal nerve originate?
In the ipsilateral hypoglossal nucleus
If there is damage to the hypoglossal nerve, sticking your tongue out deviates…..
toward the side of the lesion
Branchiomeric nerves innervate….
striated muscle of branchail (pharyngeal) arch origin (they all contain pharyngeal motor fibers.
T/F The trigeminal nerve is the general sensory nerve for the head
True
What type of information (type of sensation) is the trigeminal system resposnsible for?
Transmission of tactile, proprioceptive, and pain and temperature infromation from the head to the cortex, cerebellum and reticular formation
What are the three divisions of the trigeminal nerve?
1) Ophthalamic
2) Maxillary
3) Mandibular
The main sensory nucleus of the trigeminal nerve receives information about….
Touch and jaw position
Tactile afferent are…..
Large diameter, heavily myelinated
The main sensory nucleus of the trigmenial nerve gives rise to these two tracts…..
1) Anterior Trigeminothalamic Tract (cross midline to join medial lemniscus)
2) Posterior Trigeminothalamic Tract (uncrossed, not part of medial lemniscus)
The spinal trigeminal nucleus receives information about….
Pain and temperature
What are the three subdivisions of the spinal trigmenial nucleus and which is responsible for receiving pain and temperature information from the head?
1) Most caudal: Caudal Nucleus
2) Interpolar Nucleus
3) Most rostral: Oral Nucleus
***Caudal Nucleus responsible for processing pain and temp info***
Afferents conveying pain and temperature information in the spinal trigeminal tract are (small/large) diameter
Small
What is the systematic organization of the divisions of the trigmenial nerve with respect to the caudal spinal trigeminal nucleus?
Mandibular Division fibers are most posterior
Ophthalamic Fibers are most anterior
Maxillary lie somewhere in between
Neurons in the anterior parts of the caudal nucleus (trigeminal system) respond to areas of the face in the…..
Ophthalamic Distribution
The trigeminal motor nucleus innvervates muscles of….
Mastication
Where is the trigeminal motor nucleus located?
In the midpons at the level of attachment of the trigeminal nerve to the brainstem
The facial nerve innervates muscles of….
Facial Expression
What is the nucleus of origin for the facial nerve?
The facial motor nucleus
Where is the facial motor nucleus located?
In the anterolateral tegmentum of the caudal pons
Which nucleus is involved in the corneal blink reflex?
The facial motor nucleus
What is the corneal blink reflex?
If EITHER cornea is touched by a foreign object, BOTH eyes automatically blink
Sensory innervation of the cornea is by way of which division of the trigeminal nerve?
Opthalamic
The corneal blink reflex tests….
Both trigeminal nerves and both facial nerves
What are corticobulbar neurons?
Upper motor neurons originating in the cortex of the frontal lobe that supply the MOTOR nuclei of the cranial nerves
Damage to the facial nerve or the facial motor nucleus affects the…
Ipsilateral half of the face
A lesion of motor cortex or corticobulbar fibers results in damage to which side of the face?
The contralateral half
T/F The glossopharyngeal nerve conveys information from intraoral receptors
True
Much of the visceral sensory fibers of the inner mouth enter the ______ and synapse on in the _______
1) Solitary Tract
2) Solitary Nucleus
While most sensation of the tongue and throat (intraoral) enters the solitary tract and synapses on the solitary nucleus, information about pain from the pharynx and posterior part of the tongue enter the _________ tract and terminate in the __________ nucleus
1) Spinal Trigeminal Tract
2) Spinal Trigeminal Nucleus
T/F The vagus nerve is the principal parasympathetic nerve
True
A major collection of _______ ________ fibers travels in the vagus nerve to thoracic and abdominal viscera generally
1) Preganglionic Parasympathetic
Where do most of the preganglionic parasympathetic fivers that travel through the vagus nerve to thoracic and abdominal vsicera arise from?
The dorsal motor nucleus of the vagus
What is the principal parasympathetic nucleus of the brain?
The dorsal motor nucleus of the vagus
Where is the dorsal motor nucleus located?
In the floor of the fourth ventricle, just lateral to the hypoglossal nucleus
What underlies a structure in the floor of the fourth ventricle known as the vagal trigone?
The dorsal motor nucleus of the vagus
T/F Most vagal visceral sensory fibers enter the solitary tract and terminate in caudal portions of the solitary nucleus
True
Which vagal afferents are thought to enter the spinal trigeminal tract and terminate in the spinal trigeminal nucleus?
Afferents innvervating the larynx, esophagus, and lower pharynx
Vagal pharyngeal motor fibers arise in what nucleus?
Nucleus Ambiguus
What do vagal pharyngeal motor fibers innervate?
Most of the striated muscles of the larynx and pharynx
What can the gag reflex test?
The glossopharyngeal nerve (afferent limb)
The Vagus Nerve (Efferent Limb)
Brainstem damage commonly causes deficits on one side of the head and the (same/opposite) side of the body
Opposite
T/F All the exiting cranial nerves are ipsilateral to the side they innervate
True
T/F Almost all the cranial nerve nuclei deal with contralateral structures
FALSE
Almost all deal with ipsilateral structures
Practice Question (Ch 12 Q1): A patient reports to his physician with difficulty swallowing and slurred speech upon waking one morning. The pysician asks the patient to stick out his tongue, upon which the tongue deviates to the right. The most likely side of injury is the:
Right Hypoglossal Nucleus
-Tongue points to the side of lesion
Practice Question (Ch 12 Q2) A patient with a hisotry of uncal herniation, in which the midbrain is compressed against the tentorial notch, is most likely to present with:
Problems moving the eyes
Practice Question (Ch 12 Q3) An individual with a tumor that compresses only the occulomotor nerve, will present with:
The eyes pointed down and out
Practice Question (Ch 12 Q4) The cell bodies responsible for control of the muscles of mastication are found in the:
Trigeminal Motor Nucleus
What inputs does inegrated sensations of flavor require?
1) Gustatory Stimulation (stimulating taste buds)
2) Stimulation of olfactory receptors
3) Stimulation of chmical-sensitive and somatosensory free nerve endings of the trigeminal (and other nerves)
What area of the frontal lobe gives the overall sensation about food and drink by integrating multiple factors?
The orbital cortex
Which cranial nerves innervate the taste buds?
7, 9, and 10
What type of papillae contain taste buds?
Fungiform, Foliate, and Circumvallate
T/F Taste receptor cells are modified epithelial cells with neuron-like properties
True
How are taste receptor cells similar to neurons?
1) Contain transduction machinery
2) Produce receptor potentials in resposne to the appropriate taste stimuli
Second order gustatory neurons are located in…..
The Solitary Tract
What are the two things second order taste fibers do?
1) Participate in reflex activities, such as salivation, swallowing, and coughing by way of cranial nerve motor nuclei
2) Project to the cerebral cortex by way of the thalamus
The projection of 2nd order gustatory neurons to the thalamus is (crossed/uncrossed)
Uncrossed
Descrie the mode of travel of 2nd order gustatory neurons
1) Ganglia of 7, 9 and 10 project to the VMP via the Central Tegmental Tract. Gustatory cortex neurons then project to the orbital cortex of the frontal lobe
How does taste reachthe hypothalamus and the limbic system?
Gustatory cortex projects to the amygdala and that sends taste information to the hypothalamus and the limbic ststem. However, in most mammals, taste information reaches the hypothalamus and amygdala more directly though a projection from the parabrachial nuclei.
Olfaction is mediated by receptors that project directly to the…..
Telencephalon
The axons of olfactory recpetor neurons form with cranial nerve?
Cranial Nerve 1
T/F Sensory nerve ending of trigeminal nerve fibers are also found in the olfactory epithelium
T
What is the olfactory epithelium?
The beginning of the olfactory system, it is a patch of cells occupying about 1 to 2 cm of the roof and adjacent walls of the nasal cavity on each side.
How many receptor cells does each olfactory epithelium have?
Around 3 million each
What are the trigeminal endings found in the olfactory epithelium responsible for?
Noxious senstaion (not really one of smell)
T/F The olfactory receptor cells, just like taste receptor cells, are semi-neurons
False, olfactory receptor cells are true neurons
T/F The unmyelinated axons of the olfactory receptors are among the thinnest and most slowly conductin in the entire nervous system
True
The axons of olfactory receptors collect into small bundles known as the….
olfactory fila
The olfactory fila pass through the hooles in the cribiform plate of the ehmoid bone and end in the…..
Olfactory Bulb
The primary neurotransmitter released by the axons of olfactory receptors in the olfactory bulb is…..
Glutamate
What type of receptors are used by olfactory receptor neurons to be able to detect a wide range of odors?
G Protein-Coupled
T/F Olfactory information bypasses the thalamus on its way to the cerebral cortex
True
The olfactory bulb develops as an outgrowth from the…..
Telencephalon
The olfactory nerve reaches the (ipsilateral/contralateral) cerebral hemisphere and does so (directly/indirectly)
1) Ipsilateral
2) Directly (skips the thalamus)
The olfactory nerve terminates in the…..
Olfactory bulb
What is the most prominent cell type of the olfactory bulb?
The mitral cell
Describe the configuration of the mitral cell
Similar to a cortical pyramidal cell in reverse. It has an axon that emerges from the pointed side of the pyramid and moves toward the interior of the bulb to enter the olfactory tract.
A dendrite emerges from the broad side, descends to the surgace of the bulb, and receives coontacts from the incoming axons of olfactory receptors (CN 1)
What forms glomeruli?
The dendrites of the mitral cell, which spread out in large spherical arborizations
The axons of all the hundreds of olfactory receptor neurons that express a given receptor protein converge on just…….
One or two glomeruli
T/F Different odorants activate different sets of glomeruli in patterns that systematically map out the chemical properties of odorants across the surface of the olfactory bulb
True
Give a basic description of a mitral cell
Send dendrites into the glomeruli and send their axons into the olfactory tract
The olfactory bulb projects to….
the olfactory cortex
Olfactory receptor neurons wind up represented in the (ipsilateral/contralateral) cerebral hemisphere
Ipsilateral
T/F Neurons of the olfactory bulb and primary olfactory cortex respond to selected simulants while neurons of the olfactory association cortex are more likely to respond to multiple odorants
False, the relationship is switched. Olfactory bulb detects multiple odorants while the olfactory association cortex respond to selected stimuli
What are conductive olfactory deficits?
Processes that prevent odorants from reaching to olfactory epithelium
What are sensorineural olfactory deficits?
Processes that damage olfactory receptor neurons or parts of the olfactory CNS
What can cause sensorineural olfactory deficits?
Head injuries (may tear the olfactory fila loose from the olfactory bulb) or neurdegenerative diseases.
Practice Question (Ch 13 Q1): A lack of taste from the posterior aspect of the tongue, with a significant decrease in the ability to perceive bitter tastants may suggest damage to:
CN 9
Practice Question (Ch 13 Q2): The chemical neurotransmitter that is released from the depolarized taste bud to activate the cranial nerve is always…
ATP
Practice Question (Ch 13 Q3): The arrow is pointing to the __________ in this cross section of the human rostral medulla:
Primary affernt fibers of the tongue and viscera
Practice Question (Ch 13 Q4): The first cranial nerve (CN1) that detects olfaction in humans has fibers that pass through the:
Cribiform Plate
Practice Question (Ch 13 Q5): A patient comes to the emergency room after being in a car accident in which his vehicle was struck from behind. He claims he is having trouble smelling. The clinician detects that he is unable to smell coffee or cinnamon, but he did respond to the smell of ammonia. What cranial nerve may allow him to “smell” ammonia?
CN 5 (detects noxious smells such as methanol and ammonia)
Hearing and balance are dealt with by the ___ cranial nerve
8th
The _____ divisiion of the 8th cranial nerve conveys information about sound, while the _______ division signals position and movement of the head.
1) Cochlear
2) Vestibular
Auditory and Vestibular Receptor cells are located in the walls of the ___________ labyrinth
Membranous
Where is the membranous labyrinth?
It is suspended in the bony labyrinth, which is a cavity in the temporal bone
The bony labyrinth is filled with (perilymph/endolymph)
Perilymph
What is Perilymph?
Fluid similar in composition to CSF; low Potassium concentration high sodium concentration
T/F The subarachnoid space around the brain is continuous with the perilymphatic space of the bony labyrinth through a tiny canal in the temporal bone
True
What is the tiny canal called that connects the perilymphatic space with the rest of the subarachnoid space of the brain?
The Cochlear Aqueduct
The membranous labyrinth is filled with (perilymph/endolymph)
Endolymph
What is endolymph?
A fluid similar to intracellular fluids in ionic composition (high K+ concentration, Low Na+ concentration
What continuously produces endolymph?
Specialized epithelialcells called stria vascularis
The microvilli that project as a bundle from one end of the hair cell projects into the (endolymphatic interior/perilymphatic exterior)
Endolymphatic Interior
What are the three locations (labyrinth locations) where hair cells are?
Semicircular Ducts, Utricle, and the Saccule
What stimulus is transduced by the organ of corti?
Sound
What makes hair cells so rigid?
Cross-linked actin filaments
Briefly describe how hair cells operate based on mechanical stimuli (hint: how do tip links factor in and what causes the hair cells to open their channels)
1) Tip links connect each stereocilium to its next tallest neighbour
2) Deflection of the hair bundle toward tallet stereocilia stretches tip links
3) Stretching tip liinks opens mechanically gated ion channels more
4) K+ ions from endolymph flow through into the hair cells to depolarize cell
5) This cases the opening of voltage gated Ca2+ channel and increased neurotransmitter release onto 8th cranial nerve
6) Excitatory transmitter (glutamate) then causes increased firing frequency in eighth nerve fibers
T/F Deflection of hair cells away from their next tallest neighbour decreases the tension of the tip links, and causes mechanically gate ion channels to close
True