Neuro Oncology Flashcards

1
Q

MC brain tumors?

A
#1-mets 
MC primary= astrocytomas
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2
Q

What are the three main types of astrocytomas?

A
  • pilocytic
  • anaplastic
  • glioblastoma
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3
Q

Pilocytic astrocytoma:

  • gross appearance
  • microscopic appearance
  • age group
A
  • cystic, around ventricles vs cerebellum
  • Rosenthal fibers (red worms)
  • children or young adults
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4
Q

Which glioblastoma is most malignant?

A

-glioblastoma, shockingly, NOT anaplastic

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5
Q

Anaplastic astrocytoma:

  • microscopic appearance
  • life expectancy
A
  • ^^ cells, mitoses, abnormal nuclei

- less than five years

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6
Q

Glioblastoma:

  • presentation
  • age group
  • survival rate
A
  • seizures, focal deficit
  • 5th-7th decades
  • survival 12-18 months
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7
Q

Glioblastoma:

  • microscopic appearance
  • gross appearance
A
  • pseduopalisading necrosis

- butterfly (crosses corpus), ring enhancing

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8
Q

Oligodendrogliomas:

  • presentation
  • age group
  • life expectancy
A
  • seizures
  • 4th-5th decade
  • 5-10 years (can resect + chemo)
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9
Q

Oligodendrogliomas:

  • location
  • microscopic appearance
A
  • supratentorial**

- fried egg appearance

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10
Q

Ependymomas:

  • age group
  • presentation
A
  • children –> young adults

- headaches + vision changes especially in the morning

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11
Q

Ependymomas:

  • microscopic appearance
  • gross location
A
  • perivascular pseudorosettes

- fourth ventricle vs spinal cord (can be supra OR infratentorial)

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12
Q

MC spinal cord glioma?

A

ependymoma

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13
Q

Primitive Neuroectodermal Tumors:

general appearance

A

small round blue cells

blastomas

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14
Q

MC intracranial PNET

A

medulloblastoma

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15
Q

Medulloblastoma:

  • location
  • complication
  • age group
A
  • cerebellum
  • drop mets to spinal cord
  • children
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16
Q

Medulloblastoma:

  • survival rate
  • microscopic appearance
A
  • 5 years

- homer-wright rosettes

17
Q

Retinoblastoma:

-microscopic appearance

A

true rosettes

18
Q

MC type pituitary tumor

A

-functional prolactinoma

19
Q

Treatment for prolactinoma:

A
  • bromocriptine

- transnasal resection

20
Q

Meningiomas:

  • source
  • microscopic appearance
  • gross appearance
A
  • arachnoid cells (not CNS)
  • psammoma bodies
  • dural tail
21
Q

Brain mets:

-appearance

A

-multiple small lesions, poorly circumscribed, often at gray white junction

22
Q

What are the most common tumors that cause brain mets?

A

Lots of Bad Stuff Kills Glia

  • Lung
  • Breat
  • Skin (melanoma)
  • Kidney
  • GI
23
Q

What brain mets are most likely to hemorrhage?

A
  • renal
  • melanoma
  • choriocarcinoma
24
Q

True Rosette:

-appearance + assc tumor

A
  • central lumen

- retinoblastoma

25
Q

Homer-Wright Rosette:

  • appearance
  • assc tumor
A
  • medulloblastoma

- cytoplasmic process in center

26
Q

Perivascular Pseudorosette

  • appearance
  • assc tumor
A
  • vessel at center

- ependymoma