Neuro-oncology

Question 0

What is morvan syndrome

Answer 0

Paraneoplastic limbic encephalitis. Clinical features include cognitive and autonomic dysfunction, severe insomnia and peripheral nerve hyperexcitability. This is linked to antibodies to voltage-gated potassium channel and can be associated with malignant hyperthermia

Question 1

What is the most appropriate treatment for central nervous system non-Hodgkin lymphoma

Answer 1

Whole brain radiation

Question 2

What are findings in neurofibromatosis type 2

Answer 2

AutoSommal dominant disorder which can cause bilateral vestibular Schwannomas. Meningiomas can also be seen but Schwannomas more likely with bilateral lesions

Question 3

What antibodies are frequently encountered in paraneoplastic cerebellar degeneration

Answer 3

Anti- Yo, Hu, Tr, Ri and mGluR1. Yo is frequently associated with breast or ovarian cancer

Question 4

Anti-La auto antibodies are associated with what

Answer 4

Sjogren’s syndrome

Question 5

What is the most likely cause of pediatric opsoclonus-myoclonus syndrome

Answer 5

50% of the cases are Paraneoplastic secondary to neuroblastoma the remainder of the patients are felt to have post-infectious etiology . Clinical features include multi directional rapid eye I oscillation movements, spontaneous and at times gaze evoked nystagmus they also might develop myoclonia’s and arms and legs and difficulty walking