neuro drugs Flashcards
neostigmine vs physostigmine
- neostigmine does not enter CNS, used for tx of myasthenia graves
- physostigmine: does enter CNS, used for Ach tox
MAOI’s have SE of… when combined with…
- hypertensive crisis
- tyramine containing foods: aged cheese, beer, wine
what disease process leads to oligoclonal IgG bands on CSF analysis… and what is tx…
- MS
- beta-interferon
barbiturates vs benzodiazepines (MOA)
-barbs increase duration of Cl- channel opening
-benzos increase frequency of Cl- opening
(both target Cl- channel next to GABA receptor
serotonin syndrome
- complication of combining SSRI and MAOI
- causes hyperpyrexia, muscle rigidity, cardiovascular collapse and mental status changes
clozapine (tx for, SE)
- atypical-anti psychotic
- SE: agranulocytosis, need to get WBC checked every week, tx with granulocyte colony stimulating factor
atropine
- non-selective muscarinic receptor antagonist
- used prior to surgery to prevent bronchial secretions and after surgery to counteract acetylcholinesterase inhibitors used to bring patient out of paralysis
ethosuximide (tx, MOA, SE)
- absence Sz
- blocks t-type channels
- stevens-johnson
flucytosine
-tx for fungal meningitis (cryptococcal)
endrophonium (what is it used for, MOA)
- used to diagnose myasthenia gravis
- acetylcholine esterase inhibitor, short half life
donepezil (MOA, tx for)
- acetylcholine esterase inhibitor
- alzheimers
chlordiazepoxide (what class, tx for)
- benzo
- delirium tremens
organo-phosphate poisoning… (results in, tx)
- SLUDGE
- excess Ach, tx with muscarinic antagonist Atropine
enflourane (class, use, benefits, SE)
- inhaled anesthetic
- induction
- rapid induction and recovery
- Sz!!! but usually self-limited and no log term neurological deficits
drug side effect leading to spina bifida
-anti-convulsants (also, folate deficiency (duh) and diabetes)
