MSK

Question 1

-isoniazid

Answer 1

• MOA: inhibit synthesis of mycolic acids, unique to envelope of TB
• SE: lupus like syndrome (also caused by procainamide and phenytoin)

Question 2

allopurinol

Answer 2

• MOA: inhibit xanthine oxidase
• tx: chronic treatment of gout, disrupts uric acid synthesis
• do not give during acute flare, can prolong the pain/inflammation

Question 3

probenecid

Answer 3

• MOA: increase excretion of uric acid in urine

- tx: chronic gout, also don’t use in acute flare, does not treat pain and inflammation, can prolong