Neuro Flashcards

1
Q

What are the 4 lobes of the brain?

A

Frontal lobe
Parietal lobe
Temporal lobe
Occipital lobe

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2
Q

What does is the action of the frontal lobe? (what does it contain?)

A
  • Contralateral motor movement.
  • Broca’s area: Speech and writing
  • Intellectual functioning
  • Thought processing
  • Reasoning
  • Memory
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3
Q

What it the action of the parietal lobe?

A
Interprets sensation (pain, touch, pressure)
Proprioception
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4
Q

What is the action of the temporal lobe? (what does it contain?)

A

Wernicke’s area: understanding the spoken word

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5
Q

What does the occipital lobe control?

A

Processing visual images

Understanding written words

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6
Q

What is the action of the cerebellum?

A

Receives information from the sensory systems, the spinal cord, and other parts of the brain and then regulates motor movements.
Coordinates voluntary movements such as posture, balance, coordination, and speech.

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7
Q

Draw out the circle of willis:

A

From bottom up:
Basillar artery (with pontine arteries coming off)
Superior cerebellar artery
Posterior cerebral artery
Posterior communicating artery links these to middle cerebral arteries (internal carotids inside this)
Anterior communicating artery links these to anterior cerebral artery

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8
Q

What arteries are responsible for the blood supply to the brain?

A

Internal carotids

Vertebral arteries

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9
Q

Where do the internal carotid arteries originate from?

A

Common carotid arteries which arise (right arises from the brachiocephalic artery- first branch of aorta)

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10
Q

Where do the vertebral arteries originate?

A

Left and right subclavian arteries (right comes off brachiocephalic artery)

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11
Q

What part of the brain does the anterior cerebral artery supply?

A

Anteromedial portion of the cerebrum (middle front)

Supplies motor cortex

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12
Q

What part of the brain does the middle cerebral artery supply?

A

Majority of the lateral part of the brain

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13
Q

What part of the brain does the posterior cerebral artery supply?

A

Medial and lateral parts of the posterior cerebrum . (back of the brain)

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14
Q

What vein do all venous sinuses drain into?

A

Internal jugular vein

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15
Q

What are the main venous sinuses of the brain?

A

Superior sagittal sinus

Inferior sagittal sinus

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16
Q

Where do the 11 venous sinuses of the brain converge?

A

Confluence of sinuses (overlying internal occipital protuberance)

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17
Q

What is the straight sinus a continuation of?

A

The inferior sagittal sinus and great cerebral vein

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18
Q

What happens after the confluence of sinuses?

A

The transverse sinus continues bi-laterally and curves into the sigmoid sinus to meet the opening of the internal jugular vein.

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19
Q

What/ where is the cavernous sinus?

A

Paired dural venous sinus locates on either side of the sella turcica of the sphenoid bone

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20
Q

What structures are in the cavernous sinus?

A
O TOM CAT
Oculomotor nerve
Trochlear nerve
Opthalmic branch + 
Maxillary branch of trigeminal nerve
Carotid (internal) artery
Abducens nerve
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21
Q

What are the ventricles of the brain and what are they responsible for?

A

Hollow spaces in the middles of the brain, responsible for the porduction, transport and removal of CSF.

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22
Q

What is the fornix of the brain?

A

C-shaped bundle of white matter (nerve fibres) that acts as a major output tract of the hippocampus

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23
Q

What does the fornix connect?

A

2 brain hemispheres, limbic system

Connects hippocampus to mammillary bodies

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24
Q

What is the limbic system of the brain?

A

Set of brain structures involved in behavioural and emotional responses (especially those for survival: feeding, reproduction, fight/flight)

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25
What structures are in the limbic system?
Hypothalamus Amygdala Thalamus Hippocampus
26
What/ where is the hypothalamus?
Small region near the pituitary gland that plays an important role in releasing hormones and regulating body temperature
27
What/ where is the amygdala?
Collection of cells near the base of the brain, 1 in each hemisphere. Responsible for emotional memories (emotions are given meaning and remembred/ given associations)
28
What/ where is the thalamus?
Small structure located just above the brain stem with extensive connections to the cerebral cortex and midbrain. Primary function is to relay motor and sensory signals to the cerebral cortex.
29
What/ where is the hippocampus?
Structure deep within the temporal lobe of each cerebral cortex. Principally involved in storing long-term memories.
30
What is the cerbral cortex?
The outer layer of the cerebrum, made up of grey matter. | Contains the 4 lobes
31
What is the inner layer of the brain?
White matter
32
What is the difference between the grey and white matter of the brain?
Grey matter contains cell bodies, dendrites and axon terminals White matter is made up of myelinated axons, connecting different parts of grey matter to each other.
33
What is the coronal plane?
The frontal plane that separates the front and back
34
What is the sagittal plane?
Longitudinal plane, splits the body left to right.
35
What is the transverse plane?
Horizontal plane, divides the body superiorly and inferiorly
36
What does rostral mean?
Towards the nose
37
What does caudal mean?
Towards the tail
38
What do dorsal and ventral mean in the brainstem/ spinal cord?
``` Dorsal= posterior Ventral= anterior ```
39
What do dorsal and ventral mean in the cerebrum?
``` Dorsal= superior Ventral= inferior ```
40
What are the meninges?
The membranous vocerings of the brain and spinal cord
41
What are the 3 layers of the meninges?
Dura mater Arachnoid mater Pia mater
42
Which layer is the dura mater?
Outer layer firmly adhered to the inside of the skul?l
43
Which layer is the arachnoid mater?
Middle layer that is more adherent to the brain, keeping CSF in contact with it.
44
What is the pia mater?
Meningeal layer on the surface of the brain that cannot be separated from it (microscopic layer)
45
What are oligodendrocytes?
The myelinating cells of the CNS (produce the insulating sheath on axons)
46
What are Schwann cells?
Type of glial cell that forms the myelin sheath in the peripheral nervous system
47
What are glial cells?
Cells of the nervous system that are non-neuronal (don't produce electrical impulses)
48
In what direction are afferent axons signal going?
Towards CNS (sensory fibres)
49
In what direction are efferent signals going?
From CNS to another site (motor fibres)
50
Where is CSF produced?
By ependymal cells in the choroid plexuses of the lateral ventricles
51
What is the passage of CSF?
Lateral ventricles--> 3rd ventricle (via intraventricular foramen)--> 4th ventricle (via cerebral aqueduct
52
How does the CSF connect to the subarachnoid space?
From the 4th ventricle via the median foramen of Magendie and two lateral foramen's of Lushka
53
What is hydrocephalus?
Abnormal accumulation of CSF in the ventricular system (often due to blocked cerebral aqueduct)
54
What is the autonomic nervous system?
System that acts unconsciously to regulate bodily functions.
55
What is the somatic nervous system?
Voluntary nervous system: controls movement
56
What is the sympathetic nervous system?
Fight or Flight section of the autonomic nervous system
57
What is the parasympathetic nervous system?
Rest and digest section of the autonomic nervous system
58
Where does the sympathetic nervous system leave the CNS?
From the thoracic and lumbar regions (T1 - L2)
59
What is a ganglia?
Ovoid structure containing cell bodies of neurons and glial cells supported by connective tissue. Function like relay stations
60
What are the sympathetic trunks?
Two chains of ganglia on each side of the spinal cord
61
What neurotransmitter/ receptor type is used at the preganglionic synapses of the sympathetic nervous system?
Acetyl-choline (ACh) | Nicotinic receptors
62
What neurotransmitter is used at the effector synapses of the sympathetic nervous system? (name of receptor?)
Noradrenaline | Adrenergic receptors
63
What amplifies the effects of the sympathetic nervous system?
The adrenal glands releasing adrenaline into the blood
64
What are the main actions of the sympathetic nervous system?
``` Increases heart rate Increases force of contractinos Vasoconstriction Bronchodilation Reduces gastric motility Sphincter contraction Decreased gastric secretions Male ejaculation ```
65
Where does the parasympathetic nervous system leave the CNS?
Brainstem and sacral portion of spinal cord
66
Where are the preganglionic fibres of the parasympathetic nervous system located?
Within 4 nuclei located in the brainstem and associated with a cranial nerves that carry the fibres out of the brain.
67
Which cranial nerves carry parasympathetic fibres out of the brain?
1973: CN3: Via oculomotor nerve to pupil and facial nerve CN7: Facial nerve to salivary glands CN9: Glossopharyngeal nerve for swallowing reflex CN10: Vagus nerve to thorax and abdomen
68
What happens to the parasympathetic fibres from each nuclei after they leave the brain?
They synapse in a peripheral ganglion and continue to organs in the head and neck
69
What are the 4 parasympathetic ganglia located within the head?
Ciliary | Otic
70
What do the parasympathetic fibres that leave the CNS at the brainstem supply?
Head, neck thorax and abdomen
71
What do the parasympathetic fibres that leave the CNS at the sacral portion supply?
Abdominal and pelvic organs
72
Where do ganglia usually lie in the parasympathetic nervous system?
Within/ very close to the organs that they innervate
73
What neurotransmitter and receptor is used at the pregnaglion neurone synapse in the parasympathetic nervous system?
ACh and nicotinic receptors
74
What neurotransmitter and receptors are at the effector cell synapse in the parasympathetic nervous system?
ACh, muscarinic receptors
75
What are the main functions of the parasympathetic nervous system?
``` Decreases heart rate Decreases force of contraction Vasodilation Bronchoconstriction Increases gastric motility + secretions Sphincter relaxation Male erection ```
76
What and where is the motor cortex?
Region of the frontal lobe responsible for voluntary movement.
77
Where do the upper motor neurones originate?
The motor cortex
78
Where do the lower motor neurones originate?
From upper motor neurones in the brain stem or spinal cord
79
What is spasticity?
When there is an abnormal increase in muscle tone
80
What is muscle tone?
The tension in a muscle at rest
81
What is rigidity?
Increased muscle contraction that is continuous
82
What is the vertebral column made up of?
7 Cervical verterbra 12 Thoracic vertebra 5 lumbar vertebra (fused) 4 coccyx vertebra (fused)
83
How many spinal nerves are they and how many in each segment?
``` 31 Cervical: 8 Thoracic: 12 Lumbar: 5 Sacral: 5 Coccyx: 1 ```
84
What is the conus and where does it end?
End of the spinal cord that finished before L2
85
What is the cauda equina?
The structure formed by the spinal nerves that arise from the end of the spinal cord bundling together
86
Where do the spinal nerves originate and together what do they form?
From the spinal cord, forming the peripheral nervous system
87
What does each spinal nerve begin as?
An anterior (motor nerve) and posterior (sensory) nerve root
88
Where do the spinal nerve roots unite to form a single spinal nerve?
Interverterbral foramina
89
What do spinal nerves divide into after leaving the vertebral canal?
Posterior and anterior rami
90
What does the posterior rami supply?
Synovial joints of vertebral column, deep muscles of back and overlying skin
91
What do the anterior rami supply?
Remaining area of the body
92
Where do the spinal nerves of the different sections tend to exit the cord?
Cervical: around 1 vertebra higher than they originate Thoracic: 1-2 vertebra below corresponsing vertebra Lumbar: 3-4 vertebra blow Sacral: 5 vertebra below
93
What is a dermatome?
Area of skin supplied by a single sensory spinal nerve
94
What is the sensory innervation of the hand?
Little finger = Ulnar nerve (C8) Index finger= Median nerve (C7) Thumb= C6
95
What is myotome?
A volume of muscle supplied by a single spinal nerve
96
What does the phrenic nerve supply and where does it originate?
C3,4,5 keep the diaphragm alive!
97
What nerves supply the penis?
S2,3,4 keeps the penis off the floor
98
From which direction are all Xrays/ MRI/ CT scans taken?
From foot to head
99
What are ascending tracts?
The somatosensory pathways by which SENSORY information from the peripheral nerves is transmitted to the cerebral cortex
100
What are the two types of ascending tract?
Conscious tracts | Unconscious tracts
101
What are the main ascending tracts?
Dorsal column-medial lemniscal pathway Anterolateral system (spinothalamic tracts) Spinocerebellar tracts
102
What does the DCLM pathway carry?
Fine touch (tactile) sensation Vibration Proprioception
103
Where does the DCLM tract get its name?
Doral column-medial lemniscal pathway: | Travels in the dorsal (posterior) columns and is transmitted through the medial lemniscus in the brain stem.
104
What neurones are involved in the DCLM pathway?
First, second and third order neurones
105
What do first order neurones do?
Carry sensory information from the peripheral nerves to the medulla oblongata.
106
What are the two pathways that first order neurones can take?
``` Fasciculus cuneatus (lateral part of dorsal column) - Takes signals from upper limb Fasciculus gracilis (medial part of dorsal column)- takes signals from lower limb. ```
107
Where do the fasciculus cuneatus/ gracilis (first order neurones of DCLM tract) synapse?
Nucleus cuneatus/ gracilis of medulla oblongata
108
What is the action of the second order neurones of the DCLM tract?
Deliver information from the first order neurones in the medulla oblongata to the third order neurones in the thalamus.
109
What do the second order neurones do in the medulla oblongata?
Decussate
110
What is the lemniscus?
Bundle of sensory fibres in the brainstem
111
What do the third order neurones of the DCLM pathway do?
Transmit the sensory signals from the thalamus to the ipsilateral primary sensory cortex of the brain, travelling through the internal capsule
112
What does the anterolateral system consist of?
Anterior and lateral spinothalamic tracts
113
What sensations does the anterior spinothalamic tract carry?
Crude touch and pressure
114
What sensations does the lateral spinothalamic tract carry?
Pain and temperature
115
Where do the first order neurones of the spinothalamic tracts arise and synapse?
Arise from sensory receptors in the periphery, ascend 1-2 vertebral levels and synapse at tip of dorsal horn (substantia gelatinosa)
116
What are the dorsal horns?
Where the grey matter, containing cell bodies of sensory neurons, forms two arms at the back of the spinal cord.
117
Where are the cell bodies for the sensory spinal nerve fibres?
Dorsal root ganglion in the dorsal root (Dorsal and ventral root come out of spinal cord before forming spinal nerve)
118
What is in the centre ('H' shape) of the spinal cord?
Grey matter containing nerve cell bodies
119
What surrounds the grey matter of the spinal cord/
White matter containing axons (spinal tracts)
120
Where do the second order neurones of the spinothalamic tract begin and synapse?
Carry sensory information from substantia gelatinosa (dorsal horn) to the thalamus
121
Where do the fibres of the spinothalamic tract decussate?
Second order neurones decussate within the spinal cord
122
What do the second order neurones form after decussating in the spinal cord?
Two distinct tracts: Crude touch and pressure fibres Pain and temperature fibres
123
Where do the crude touch and pressure fibres travel up the spinal cord?
In the anterior spinothalamic tract
124
Where do the pain/ temperature fibres travel up the spinal cord?
In the lateral spinothalamic tract
125
Where do the third order neurones of the spinothalamic tract travel?
From the thalamus, through the internal capsule to the ipsilateral primary sensory cortex .
126
What tracts carry unconscious proprioceptive sensation to the brain?
Spinocerebellar tracts
127
What are the 4 pathways in the spinocerebellar tracts?
Posterior spinocerebellar tract Cuneocerebellar tract Anterior spinocerebellar tract Rostral spinocerebellar tract
128
Where do the spinocerebellar tracts carry information to?
Ipsilateral cerebellum
129
What senses do the following carry: - DCLM tract - Anterior spinothalamic tracts - Lateral spinothalamic tract - Spinocerebellar tracts
DCLM= Proprioception, fine touch and vibration Anterior spinothalamic= crude touch/ pressure Lateral spinothalamic= temperature/ pain Spinocerebellar= unconscious proprioception
130
What are the descending tracts?
Pathways that carry motor signals from the brain to the lower motor neurones
131
What are the two major groups of the descending tract?
Pyramidal tracts | Extrapyramidal tracts
132
Where do the pyramidal tracts originate?
The cerebral cortex
133
Where do the pyramidal tracts carry motor fibres to?
The spinal cord and rain stem
134
What muscles do the pyramidal tracts control?
Voluntary control of body and facial muscles.
135
Where do the extrapyramidal tracts originate and travel to?
Originate in the brain stem and carry fibres to the spinal cord
136
What is the action of the extrapyramidal descending tracts?
Involuntary and autonomic control of all musculature (muscle tone, balance, posture and locomotion)
137
Are there synapses within the descending pathways?
No
138
Where do the descending pathways synapse?
With lower motor neurones at the end of the descending tracts.
139
What are the neurones of the descending tracts classed as?
Upper motor neurones
140
Where are the upper motor neurone cell bodies located?
In the cerebral cortex or brain stem.
141
Why are they called pyramidal tracts?
Because they pass through the medullary pyramids of the medulla oblongata
142
What are the two pyramidal tracts?
Corticospinal | Coricobulbar
143
What does the corticospinal tract supply?
The musculature of the body
144
Where do the corticospinal tracts begin and where are the inputs from?
Begin in the cerebral cortex, with inputs from the: - primary motor cortex - premotor cortex - supplementary motor area - somatosensory area
145
After originating from the cortex, where do the corticospinal neurones convrege and descend through?
Internal capsule
146
What is the internal capsule?
A white matter pathway, located between the thalamus and basal ganglia
147
What makes the internal capsule vulnerable?
It is particularly susceptible to compression from haemorrhagic bleeds (capsular stroke)
148
Where do the neurones pass through after leaving the internal capsule?
Crus cerebri of midbrain, pons and medulla.
149
Where does the corticospinal tract divide into two and what are the two?
Divides into the lateral and anterior corticospinal tract in the medulla.
150
Where do the fibres of the lateral corticospinal tract decussate and terminate?
Decussate in the medulla and descend into the spinal cord, terminating at the ventral horn of all segmental levels.
151
Where do the corticospinal tracts decussate and they terminate?
Remain ipsilateral, descend into the spinal cord and then decussate and terminate in the ventral horn of the cervical and upper thoracic segments.
152
What do the corticobulbar tracts supply?
Musculature of the head and neck
153
Where do the corticobulbar tracts arise?
Lateral aspect of the primary motor cortex. (with same inputs as corticospinal tracts)
154
Where do the fibres converge and travel to?
Converge and pass through the internal capsule to the brainstem.
155
Where to corticobulbar neurones terminate?
Motor nuclei of the cranial nerves, where they synapse with lower motor neurones to carry motor signals to the face and neck.
156
Do the corticobulbar fibres innervate the motor neurones ipsi, contra or bilaterally? What are the exceptions?
Bilaterally (both sides no matter where the input is from) Facial nerve has a ontralateral innervation (affecting muscles in lower quadrant of face) Hypoglossal nerve is contralateral
157
What are the extrapyramidal tracts?
Descending spinal tracts that carry motor fibres responsible for involuntary and autonomic control of all musculature.
158
Where to the extrapyramidal tracts originate?
The brainstem
159
What are the 4 extrapyramidal tracts?
Vestibulospinal Reticulospinal Rubrospinal Tectospinal
160
What are the vestibulospinal tracts respondible for and contra or ipsilateral?
Responsible for balance and posture | Ipsilateral.
161
What are the reticulospinal tracts responsible for?
Medial: Arises from pons and facilitates voluntary movement and increases muscle tone Lateral: Arises from medulla and inhibits voluntary movements and reduces muscle tone
162
What are the rubrospinal tracts responsible for?
Uknwon- fine control of hand movements/
163
Where do the rubrospinal tracts originate and do they decussate?
Originate in red nuclues (in midbrain) and decussate, creating contralateral innervation
164
What are the tectospinal tracts responsible for?
Coordinates movements of the head in relation to vision stimuli.
165
Where do the tectospinal tracts originate and decussate?
Superior colliculus of midbrain (recieves input from optic nerves) then decussates and enters the spinal cord.
166
What is Brown-Sequard syndrome?
Damage to one half of the spinal cord (hemisection)
167
What are potential causes of Brown-sequrd syndrome?
Trauma (e.g. knife wound) Troke Inflammatory disease (e.g. multiple sclerosis, tuberculosis)
168
What does Brown-sequard cause?
Ipsilateral loss of proprioception, motor and fine touch | Contralateral loss of pain, temperature and crude touch.
169
What are the cranial nerves?
``` I: Olfactory II: Optic III: Oculomotor IV: Trochlear (3) V: Trigeminal VI: Abducens VII: Facial VIII: Vestibulocochlear IX: Glossopharyngeal X: Vagus XI: Accessory XII: Hypoglossal ```
170
Which cranial nerves are sensory/ motor?
``` Some Say Marry Money But My Brother Says Big Brains Matter More ```
171
Which of the cranial nerves are parasympathetic?
3,7,9, 10
172
What is Broca's area?
The language centre of the brain
173
Where is Broca's area?
Dominant (usually left if right handed) frontal lobe
174
What is Broca's area responsible for?
Articulation of speech
175
What does damage to Broca's area cause?
Expressive aphasia: Partial loss of ability to produce language (spoken, manual or written) despite intact comprehension
176
What is Wernicke's area?
Comprehension centre responsible for understanding speech
177
Where is Wernicke's area?
Dominant temporal lobe
178
What does damage to Wernicke's area cause?
Comrehension/ receptive aphasia
179
What does the external carotid artery supply?
Everything in the head and neck except the brain
180
What will be affected if there is an ischaemic stroke in the anterior cerebral artery?
Lower limbs
181
What will be affected if there is an ischaemic stroke in the middle cerebral artery?
Chin to hip
182
What will be affected if there is an ischaemic stroke in the posterior cerebral artery?
Peripheral vision loss
183
What will be affected if there is an ischaemic stroke in the posterior inferior cerebellar artery?
Medulla, resulting in lateral medullay syndrome: dysphagia, slurred speech, ataxia, facial pain, loss of pain/ sensation on opposite side of the body
184
What are berry aneurysms?
Most common type of brain aneurysm that occurs in the circle of Willis
185
What is an aneurysm?
Bulge in a blood vessel caused by a blood vessel wall weakness.
186
What is the brainstem made up of?
Midbrain Pons Medulla oblongata
187
What is the midbrain made up of?
Tectum | Cerebral peduncles
188
What is the substantia nigra?
Pigmented nucles (basal ganglia structure) in the midbrain that separates the two cerebral peduncles
189
What is the tegmentum?
Region of grey matter in the midrbain
190
What is the pons?
The largest part of the brainstem, connecting the medulla and midbrain.
191
What important things does the pons contain?
Cranial nerve nuclei
192
What is the medulla and what does it contain?
The lowest part of the brainstem, containing nerve tracts and brainstem nuclei.
193
What is the action of the cerebellum?
Responsible for coordinating voluntary movements.
194
What is the floor of the cavity made up of?
Anterior, middle and posterior cranial fossa
195
What bones make up the anterior cranial fossa?
Frontal Ehtmoid Sphenoid
196
What bones make up the middle cranial fossa?
Sphenoid Temporal Parietal
197
What bones make up the posterior cranial fossae?
Sphenoid Parietal Temporal Occipital
198
Where does the spinal cord finish?
L1
199
Where is epidural anaesthetic given and why?
In/ around dura mater below L1 so that the brain will still control breathing will the lower body is anaestestised.
200
How does epidural anaesthetic work?
Administered into epidural space and diffuses into dorsal root ganglia on sensory nerves, stopping sensory neurones from working
201
What is a lumbar puncture?
Spinal tap: Very sharp needle inserted to penetrate dura and sample CSF
202
What are the main diagnostic brain specific tests?
Nerve conduction studies Electromyography Electroencephalography
203
What are nerve conduction studies?
Look at the peripheral nervous system and assess sensory/ motor function. Nerve is stimulated with electrodes.
204
What does it indicate if there is only a small response in a nerve conduction study?
There has been axon loss
205
What does it indicate if there is a slow response in a nerve conduction study?
Myelin loss
206
What is EMG?
Electromyography: | Can detect myopathies by recording the electrical activity in skeletal muscles.
207
What is an EEG?
Electroencephalography- tests electrical activity of brain
208
How do you examine a head injury?
Glasgow coma scale Look at laterlising signs Look at pupils
209
What is a stroke?
A cerebrovascular accident
210
What can cause disruption of cerebral blood supply?
Thrombus/ embolus (especially in atrial fibrillation) Atherosclerosis Shock Vasculitis
211
What is a TIA?
Transient ischaemic attack: Neurological dysfunction caused by temporary cerebral ischaemia (without infarction)
212
What time period do TIA symptoms usually resolve within?
24 hours
213
What is a crescendo TIA?
Two or more TIAs within a week
214
What do TIA's often precede?
Full stroke
215
What are the typical symptoms of a stroke?
Sudden onset of asymmetrical: - Limb weakness - Facial weakness - Dysphasia (speech disturbance) - Visual/ sensory loss
216
What are the risk factors for a stroke?
``` Cardiovascular disease (angina, MI, peripheral vascular disease) Previous stroke/ TIA Atrial fibrillation Carotid artery disease Hypertension Diabetes Smoking Vasculitis Thrombophilia Combined contraceptive pill ```
217
What is the pneumonic for recognising a stroke?
``` FAST: Face Arm Speech Time (act fast) ```
218
What are the two causes of a stroke?
Ischaemia/ infarction of brain tissue secondary to inadequate blood supply or Intracranial haemorrhage.
219
What is the initial management of a suspected stroke?
Exclude hypoglycaemia Immediate CT to exclude primary intracerebral haemorrhage Aspirin 300mg stat
220
How is an ischaemic stroke treated?
Thrombolysis with alteplase (thrombolytic medication) | Thrombectomy (mechanical removal of clot) if severe occlusion is confirmed
221
What are post thrombolysis complications and how are they monitored for?
Intracranial or systemic haemorrhage | Repeated CT scans of the brain
222
How quickly does alteplase have an effect?
Within 4.5 hours
223
Why should blood pressure not be attempted to be lowered during a stroke?
To prevent reduced perfusion to the brain
224
How is TIA managed?
Start aspirin 300mg daily Start secondary prevention measures for cardiovascular disease Refer to stroke specialist
225
Why is imaging used in a stroke and what techniques are used?
To establish the affected vascular territory: Diffusion-weighted MRI CT Carotid ultrasound (to assess for carotid stenosis)
226
What is the secondary prevention of stroke?
Antiplatelet (clopidogrel) Statin (Atorvastatin) Carotid endarterectomy/ stenting in patients with carotid artery disease Treat modifiable risk factor (e.g. hypertension/ diabetes)
227
What rehabilitation support might patients who have had a stroke require?
``` MDT: Nurses Speech and language therapy Dieticians Physiotherapy Occupational therapy Social services Optometry/ ophthalmology Psychology Orthotics ```
228
What percentage of strokes are caused by intracranial bleeds?
10-20%
229
What are the layers between the brain and the skull in order?
``` Skull Dura mater Arachnoid mater Subarachnoid space Pia meter Brain ```
230
What is a haemorrhage?
Escape of blood from ruptured blood vessel
231
What are the risk factors for haemorrhagic stroke?
``` Head injury Hypertension Aneurysm Progression of iscaehemic stroke Brain tumours Anticoagulants ```
232
How do haemorrhagic strokes present?
``` Sudden onset headache Seizures Weakness Vomiting Reduced consciousness ```
233
What assessment tool is used to assess consciousness? What is the maximum score?
Glasgow coma scale Max score= 15 Should secure airway if below 8
234
What is a subdural haemorrhage/ hematoma?
Collection of blood in the subdural space (between dura and arachnoid mater)
235
What causes a subdural haemorrhage?
Rupture of the bridging veins in the outermost meningial layet
236
What is the usually cause of an acute subdural hematoma?
External trauma creating tension in the walls of a bridging vein in the subdural space .
237
What does a subdural haemorrhage look like on a CT scan?
Crescent shape not limited by cranial sutures
238
In what patients do subdural haemorrhage occur more commonly and why?
Elderly/ alcoholic patients as they have more atrophy in their brains, making them more likely to rupture.
239
What are the different types of haemorrhagic stroke?
Subdural Extradural Intracerebral Subarachnoid
240
What is an extradural haemorrhage (epidural hematoma)?
Collection of blood between the skull and dura mater.
241
What is the usual cause of an extradural haemorrhage?
Rupture of the middle meningeal artery in the temporo-parietal region, often associated with fracture of the temporal bone
242
How does an extradural haemorrhage appear on a CT?
Bi-convex shape limited by cranial sutures
243
What is the typical presentation of an extradural haemorrhage?
Young patient with a traumatic head injury with ongoing headache. They have a period of improved neurological symptoms and consciousness followed by a rapid decline over hours as the haematoma gets large enough to compress intracranial structures.
244
What is a subarachnoid haemorrhage?
Bleeding into the subarachnoid space (where CSF is located between pia mater and arachnoid membrane)
245
What is the usual cause of a subarachnoid haemorrhage?
Ruptured cerebral aneurysm
246
What is the typical presentation of an subarachnoid haemorrhage?
Sudden onset occipital headache that occurs during strenuous activity (THUNDERCLAP HEADACHE) Neck stiffness, photophobia, vision changes, neurological symptoms (speech changes, weakness, seizures)
247
What are the risk factors of a subarachnoid haemorrhage?
``` Cocaine use Sickle cell anaemia Hypertension Smoking Excessive alcohol Family history Black patients Females 45-70 y/o Connective tissue disorders ```
248
What are intracerebral haemorrhages?
Bleeding into the brain tissue
249
How does intracerebral haemorrhage present?
Similarly to ischaemic stroke
250
What are the causes of intracerebral haemorrhage?
Spontaneous Result of bleeding into an ischaemic infart Tumour Aneurysm rupture
251
How are haemorrhagic strokes diagnosed?
Immediate CT | Check FBC and clotting
252
How are haemorrhagic strokes managed?
Some have surgery to remove blood from the brain/ repair burst blood vessels. (craniotomy) Correct any clotting abnormality (e.g. stop anticoagulants and give something to reverse it) Correct severe hypertension May need supportive treatment: feeding tube/ IV fluids/ ventilation
253
Why does there need to be a low clinical suspicion to trigger a full investigation os subarachnoid haemorrhage?
It has a very high mortality and morbidity.
254
What investigations are done to diagnose subarachnoid haemorrhage?
CT head: hyperattenuation in subarachnoid space Lumbar puncture (RCC, Xanthochromia- yellow colours CSF) Angiography to locate source
255
How is subarachnoid haemorrhage managed?
By specialist neurosurgical unit Patients with reduced consciousness may require intubation and ventilation Supportive care by MDT team
256
What interventions may be given to treat subarachnoid hameorrhage?
Surgical-> Repair aneurysm by coiling (inserting catherter, placing coil in aneurysm and sealing it off from the artery/ clipping- sealing aneurysm) Numodipine--> Calcium channel blocker used to treat vasospasm Lumbar puncture to treat hyercephalus Antiepileptics to treat seizures
257
What is hydrocephalus?
Accumulation of CSF fluid in the brain, increasing the pressure inside the skull
258
What is epilepsy?
Umbrella term for a condition that causes seizures
259
What are seizures?
Transient episodes of abnormal electrical activity in the brain
260
What investigations can be done to diagnose epilepsy?
EEG | MRI brain
261
What is an EEG?
Electroencephalogram, detects electrical activity in the brain using electrodes.
262
What are the main types of seizure?
``` Tonic-clonic Focal Ansence Atonic Myoclonic Infantile ```
263
What is a tonic-clonic seizure?
Seizure with muscle tensing and jerking.
264
What does tonic mean?
Muscle tensing
265
What does clonic mean?
Muscle jerking
266
What else may happen in a tonic-clonic seizure?
Tongue biting, incontinence, groaning, irregular breathing
267
What happens after a tonic-clonic seizure?
Prolonged post-ictal period: person is confused, drowsy and irritable/ depressed
268
How are tonic-clonic seizures managed?
First line: Sodium valproate | Second line: Lamotragine/ carbamazepine
269
What are focal seizures?
Seizure that starts in one side of the brain
270
What do focal seizures affect?
The temporal lobes, affecting hearing, speech, memory and emotions
271
In what ways can focal seizures present?
``` Hallucinations Memory flashbacks Deja vu Doing strange things on autopilot Strange feeling ```
272
What can focal seizures indicate?
That another type of seizure is about to happen
273
How are focal seizures treated?
First line: Carbamezepine or lamotrigine Second line: Sodium valproate, levetricetam (opposite to tonic-clonic)
274
What are absence seizures and in what patients do they usually occur?
Typically happen in children. Patients becomes blank, stares into space and is unaware of their surroundings, then abruptly returns to normal after 10-20 seconds.
275
What is the treatment of absence seizures?
Sodium valproate or ethosuximide
276
What are atonic seizures?
'Drop seizure'; Brief lapses in muscle tone that lasts less than 3 minutes.
277
What might atonic seizures indicate?
Lennox-Gastaut syndome
278
What is the management of atonic seizures?
First line: Sodium valproate | Second line: Lamotrigine
279
What are myoclonic seizures?
Sudden brief muscle contractions.
280
In what type of epilepsy are myoclonic seizures most common?
Juvenile myoclonic epilepsy
281
What is the management of myoclonic seizures?
Sodium valproate | Lamotrigine, levetiracetem, topiramate
282
What are infantile spasms?
West syndome: Rare disorder starting in infancy that causes clusters of full body spasms and has poor prognosis.
283
What is the first line medication for most forms of epilepsy? What is the exception
``` Sodium valproate (Focal seizures the exception) ```
284
What is the action of sodium valproate?
Increases activity of GABA (brain neurotransmitter), which has a relaxing effect on the brain.
285
What is the action of GABA?
CNS neurotransmitter that reduces the activity of the neurons to which it binds (inhibits nerve transmission)
286
What are the notable side effects of sodium valproate?
Teratogenic Liver damage and hepatitis Hair loss Tremor
287
What does teratogenic mean?
Disturbs the development of an embryo/ fetus and may cause birth defects/ miscarriage.
288
In which patients must sodium valproate be avoided?
Girls and women unless there are no suitable alternatives and they meet strict criteria that means they do not get pregnant/
289
What is carbamezapine used for and what is its action?
First line for focal seizures | Anti-convulsant calcium channel-blocker
290
What are the notable side effects of Carbamazepine?
``` Agranulocytosis (deficiency of granulocytes) Aplastic anaemia (body fails to produce sufficient RBC's) Many drug interactions ```
291
What are the notable side effects of Phenytoin?
Folate/ vitamin D deficiency: Megaloblastic anaemia Osteomalacia
292
What are the main side effects of ethosuximide?
Night terrors | Rashes
293
What is status epilepticus?
Medical emergency: Seizures lasting >5 minutes or more that 3 seizures in one hour.
294
How is statues epileptics managed in hospital?
``` ABCDE High concentration oxygen Assess cardiac/ respiratory function Check blood glucose levels IV lorazepam (relaxant) ```
295
What other treatments may be used for epilpesy?
Anti-epileptics Surgery to remove part of the brain causing them Inserting electrical device to help control them Ketogenic diet
296
In what aspects of life does epilepsy need to be considered?
``` Driving Certain jobs Swimming Contraception Planning a pregnancy ```
297
What are the causes of epilepsy?
``` Idiopathic Genetic Stroke Brain tumour Severe head injury Drug/ alcohol missure Brain infection Lack of oxygen during birth ```
298
What are the symptoms of a simple focal seizure and why are they called auras?
``` Remain awake General strange feeling Rising sensation in stomach Deja vu Unusual smell/ taste Tingling Intense feelings of fear/ joy Stiffness/ twitching Can be a sign that another type of seizure is about to happen ```
299
What are the symptoms of.a complex focal seizure?
``` Lose sense of awareness and make random body movements such as: Smacking lips Rubbing hands Random noises Moving arms Chewing/ swallowing ```
300
What are the two stages of a tonic-clonic seizure?
1. Tonic stage: Lose consiousness and body goes stiff | 2. Clonic stage: Limbs jerk, may lose control of bladder or bowel, bite tongue or have difficulty breathing.
301
What can trigger seizures?
``` Stress Lack of sleep Waking up Alcohol Some medicines/ drugs Periods Flashing lights ```
302
What is multiple sclerosis?
Chronic progressive condition that causes demyleniation of neurones in the CNS/
303
In what patients does MS usually present?
Young (<50) women
304
What is the action of myelin?
Covers axons of neurons in the CNS to help the electrical impulse move faster.
305
What cells produce myelin?
Schwann cells in peripheral nervous system | Oligodendrocytes in CNS.
306
What cells does MS typically affect?
Oligodendrocytes - myelin producing cells in the CNS
307
What happens in MS?
An inflammatory process is triggered, causing activation of immune cells that damage myelin and affects the way electrical signals travel along the nerve.
308
What can happen in early MS?
Re-myelination and resolution of symptoms.
309
What is the characteristic feature of MS?
Lesions disseminate in time and space: Lesions vary in their location over time, affecting different nerves and therefore causing different symptoms.
310
What are the predicted causes of MS?
Combination of: - Specific genetics - Epstein-Barr virus - Low vitamin D - Smoking - Obesity
311
How long do symptoms of MS tend to last at first presentation??
Progress over more than 24 hours and last days to weeks before improving.
312
In what ways can MS present?
``` Optic neuritis Eye movement abnormalities Focal weakness Focal sensory symptoms Ataxia ```
313
Why are symptoms more permanent in later stage MS?
Re-myelination gradually becomes more incomplete
314
What is optic neuritis?
Demyelination of the optic nerve and loss of vision in one eye.
315
What eye movement abnormalities might a patient with MS present with?
Double vision Internuclear opthalmoplegia Conjugate lateral gaze disorder
316
Why might a patient with MS have double vision?
Lesions with the sixth cranial nerve (abducens)
317
What do sixth cranial nerve lesions cause?
Internuclear opthalmoplegia | Conjugate lateral gaze disorder
318
What is internuclear opthalmoplegia?
Problems with the cranial nerve nuclei that control eye movement .
319
What is conjugate lateral gaze disorder?
When sixth cranial nerve palsy means that the eyes are unable to move together- the affected eye is unable to abduct/
320
What focal weakness may be present in MS?
Bells palsy (paralysis of facial muscles) Horners syndrome (miosis, ptosis and anhidrosis) Limb paralysis Incontinence
321
What focal sensory symptoms may be present in MS?
Trigeminal neuralgia Numbness Paraesthesia (pins and needles) Lhermitte's sign
322
What is Lhermitte's sign?
An electric shock sensation that travels down the spine and limbs when flexing the neck, caused by stretching the demyelinated dorsal column.
323
What is ataxia?
Problem with coordinated movement
324
What is sensory ataxia?
Loss of proprioceptive sense (can't sense position of joint), resulting in a positive Romberg's test
325
What is Romberg's test?
Test of the bodys sense of proprioception. (involves counting seconds patient is able to stand still with eyes closed).
326
What key sign might sensory ataxia cause?
Pseudoathetosis- abnormal writhing of the fingers.
327
What is cerebellar ataxia?
Problems with the cerebellums coordination of movement.
328
What disease patterns can MS cause?
Mild relapsing-remitting episodes for life Primary progressive MS Secondary progressive Clinically isolated syndrome
329
What is clinically isolated syndrome?
The first episode of demyelination and neurological signs and symptoms. Cannot diagnose MS until a second instance has occured but patients may only have this one episode
330
What is the most common pattern of MS at initial diagnosis?
Relapse-remitting: | Can be active, non-active, worsening or not-worsening
331
What is secondary progressive MS?
Where there was relapsing-remitting disease at first, but now there are progressive worsening of symptoms with incomplete remissions.
332
What can secondary progressive MS be further classified as?
Active: new symptoms developing/ new lesions on MRI Not active: No new symptoms/ lesions Prgressing: Overall worsening of disease over time Not progressing
333
What is primary progressive MS?
When there is a worsening of disease and neurological symptoms from the point of diagnosis without initial relapses and remissions.
334
How is MS diagnosed?
Made by neurologist based on clinical picture and symptoms suggesting lesions change location over time.
335
What is required for a diagnosis of primary progressive MS?
Symptoms to have been progressive over a period of 1 year.
336
What investigations can support a diagnosis of MS?
MRI scans | Lumbar puncture can detect oligoclonal bands in CSF
337
What is optic neuritis?
Unilateral reduced vision developing over hours-days
338
What are the key features of optic neuritis?
Central scotoma (enlarged blind spot) Pain on eye movement Impaired colour vision Relative afferent pupillary defect
339
How is optic neuritis treated?
Steroids
340
How is MS managed?
By MDT team with disease- modifying drugs and biologic therapy
341
How are MS relapses treated?
Steroids (methylprednisolone): 500mg orally for 5 days OR 1g IV for 3-5 days
342
What are symptomatic treatments of MS?
Exercise to maintatin activity and strength Amitriptyline/ Gabapentin for neuropathic pain SSRI's for depression Anticholinergics for urge incontinence Gabapentin/ physio for spasticity
343
What are the main symptoms of MS?
``` Fatigue Difficulty walking Vision problems Incontinence Numbness/ tingling Muscle stiffness/ spasms Problems with balance/ coordination Problems thinking/ learning/ planning ```
344
What is motor neurone disease?
Progressive, ulimately fatal disease where the motor neurones stop functioning.(encompasses a variety of specific diagnoses)
345
What is the most common type of MND?
Amylotropic lateral sclerosis (AML)
346
What are the main types of motor neurone disease?
AML Progressive bulbar palsy Progressive muscular atrophy Primary lateral sclerosis
347
What muscles does progressive bulbar palsy primarily affect?
Muscles of talking and swallowing.
348
What is the cause of motor neurone disease?
Unknown | Linked to genes, family history, smoking, exposure to heavy metals and certain pesticides.
349
Which neurones are affected in motor neurone disease?
Upper and lower motor neurones (not sensory)
350
What patient is the typical presentation of motor neurone disease?
Late middle aged man (e.g. 60), possible with affected relative.
351
What are the main symptoms of motor neurone disease?
Insidious (gradual), progressive weakness of the muscles throughout the body affecting the limbs, trunk, face and speech.
352
Where is muscle weakness usually first noticed in MND?
Upper limbs
353
What other symptoms (other than muscle weakness) may MND patients complain of?
``` Increased fatigue when exercising Clumsiness Dropping things Tripping over Slurred speech (dysarthria) ```
354
What are the key signs of lower motor neurone disease?
Muscle wasting Reduced tone Fasciculations (muscle twitches) Reduced reflexes
355
What are the key signs of upper motor neurone disease?
Increased tone/ spasticity Brisk reflexes Upgoing plantar responses
356
What is spasticity?
Abnormal increase in muscle tone (stiffness of muscle)
357
How is MND diagnosed?
Based on clinical presentation and excluding other conditions (made by a specialist when there is certainty)
358
How can MND be managed?
No effective treatments for halting or reversing progression. Riluzole can slow progression Edaravone Non-invasive ventilation to support breathing at night.
359
What is Parkinson's disease?
Condition where there is a progressive reduction of dopamine in the basal ganglia of the brain, leading to disorders of movementq
360
What is the classic triad of features in Parkinsons?
Resting tremor Rigidity Bradykinesia
361
What is bradykinesia?
Slowness of movement
362
What are the basal ganglia?
Group of nuclei in the middle of the brain, responsible for coordinating habitual movements such as walking or looking around.
363
Who is the typical patient presenting with Parkinsons?
Older man around 70.
364
What are the key symptoms/ signs of Parkinsons?
``` Unilateral tremor Rigidity Bradykinesia Stooped posture Facial masking Forward tilt Reduced arm swing Shuffling gait ```
365
What is the frequency of a Parkinsons tremor?
4-6 Hz (occurs 4-6 times a second)
366
What does a Parkinsons tremor look like?
Pill rolling tremor- looks like rolling pill between fingertips and thumb. More pronounced when resting or patient is distracted.
367
What is rigidity?
Resistance to passive movement of a joint (e.g. will feel tension if trying to flex and extend elbow)
368
What kind of rigidity is experienced in Parkinson's patients?
Cogwheel rigidity- tension in the arm gives way to movement in small increments
369
Whats the difference between spasticity and rigidity?
Spasticity arises as a result of daage to the corticoreticulospinal (pyramidal) tracts Rigidity is caused by dysfunction of extrapyramidal pathways (basal ganglia)
370
In what ways can bradykinesia present?
Handwriting gets smaller Shuffling gait (can only take small steps) Difficulty initiating movement Difficulty in turning around when standing Reduced facial movement and facial expressions
371
What other features can effect patients with Parkinsons?
``` Depression Sleep disturbance/ insomnia Loss of sense of smell (anosmia) Postural instability Cognitive impairment/ memory problems ```
372
How is a benign essential tremor differentiated from a Parkinson's tremor?
Benign essential is: Symmetrical 5-8 Hz (instead of 4-6) Improves at rest (P gets worse) Worse with intentional movement (P improves) No other Parkinson's features Improves with alcohol (P has no change with alcohol)
373
What are Parkinson's plus syndromes?
Atypical Parkinson's- Diseases that are linked to Parkinson's and cause a lot of the same symptoms but can bring other problems
374
What is multiple system atrophy?
Rare condition where the neurones of multiple systems in the brain degenerate
375
How does multiple system atrophy present?
Degeneration in basal ganglia leads to Parkinson's presentation, degeneration in other areas leads to autonomic dysfunction (postural hypotension, constipation, abnormal sweating, sexual dysfunction) and cerebellar dysfunction (ataxia)
376
What are some examples of Parkinson's plus syndromes?
Multiple system atrophy Dementia with Lewy bodies Progressive supranuclear palsy Corticobasal degeneration
377
How is Parkinson's diagnosed?
Clinically based on symptoms and examination
378
What produces dopamine?
Substantia nigra of the basal ganglia in the midbrain.
379
What is dopamine essential for?
The correct functioning of the basal ganlia.
380
What happens to Dopamine levels in Parkinsons?
There is a gradual but progressive fall in production
381
What medications are used control symptoms of Parkinsons?
Levodopa COMT inhibitors Dopamine agonists Monoamine Oxidase-B inhibitors
382
What is Levodopa?
Synthetic dopamine given orally to boost dopamine levels
383
What does Levodopa need to be given with?
Peripheral decarboxylase inhibitors (e.g. Carbidopa and benserazide) that stop levodopa being broken down by the body before it can enter the brain.
384
Why is Levopoda treatment reserved for when other treatments are not managing to control symptoms?
It becomes less effective over time
385
What is the main side effect of dopamine treatment?
If the dose is too high, develop dyskinesias (abnormal movements associated with excessive motor activity)
386
What are some examples of dyskinesias?
Dystonia (abnormal postures/ exaggerated movements) Chorea (abnormal involuntary movements-jerking) Athetosis (involuntary twisting/ writhing movements in hands, fingers or feet)
387
What are COMT inhibitors? (+ example)
Inhibitors of COMT enzyme which metabolises levodopa in the body and brain (e.g. entacapone)/ Is taken to slow breakdown of levodopa in the brain, extending its effects
388
What are dopamine agonists actions?
Mimic dopamine in the basal ganglia and stimulate dopamine receptors.
389
How effective are dopamine agonists and what is their main side effect?
Less effective than Levopoda | Can cause pulmonary fibrosis
390
What are monoamine oxidase-B inhibitors?
Monoamine oxidase enzymes break down neurotransmitters, and B is specific to dopamine. Therefore inhibitors block this enzyme and increase circulating dopamine.
391
What causes neuropathic pain?
Abnormal functioning of the sensory nerves delivering abnormal and painful signals to the brain
392
What are the typical features of neuropathic pain?
``` Burning Tingling Pins & needles Electric shock Loss of sensation ```
393
What can cause neuropathic pain?
``` Nerve damage from surgery Multiple sclerosis Diabetes neuralgia Trigeminal neuralgia Complex regional pain syndrome Postherpetic neuralgia from shingles ```
394
What is used to assess neuropathic pain?
DN4 questionaire
395
What are the 4 first line treatments for neuropathic pain?
Amitriptyline (Tricyclic antidepressant) Duloxetine (SNRI antidepressant) Gabapentin (antivonvulsant) Pregabalin (anticonvulsant)
396
What is trigeminal neuralgia and what is used to treat it?
Chronic pain condition affecting the trigeminal nerve of the face and brain. Treated with carbamexepine
397
Where does the facial nerve exit the brainstem?
At the cerebellopontine angle
398
What branches does the facial nerve divide into?
``` Temporal Zygomatic Buccal Marginal mandibular Cervical (Tall zulus bear many children) ```
399
What sensory function does the facial nerve carry?
Taste from the anterior 2/3 of the tongue
400
What will happen to the forehead in an upper motor neurone lesion?
The forehead will be spared and can be moved on the affected side
401
What will happen to the forehead in a lower motor neurone lesion?
The patient cannot move the forehead on the affected side.
402
How do brain tumours present?
Usually asymptomatic | As they develop, present with focal neurological symptoms, and signs and symptoms of raised intracranial pressure
403
What are the main causes of raised intracranial pressure?
``` Brain tumour Intracranial haemorrhage Idiopathic intracranial hypertension Abscess Infection ```
404
How does raised intracranial pressure present?
``` Headache that is: -Constant -Nocturnal -Worse on waking, coughing, straining or bending forward Vomiting Altered mental state Visual field defects Unilateral ptosis 3/6 nerve palsies ```
405
What is the key finding on fundoscopy when assessing for raised intracranial pressure?
Papilloedema- Swelling of the optic disc.
406
What are the different types of brain tumour?
``` Secondary metastases Gliomas Meningiomas Pituitary tumours Acoustic neuroma ```
407
What are the most common cancers the metastasise to the brain?
Lung Breast Renal cell carcinoma Melanoma
408
What are gliomas?
Tumours of the glial cells in the brain or spinal cord
409
What are glial cells?
Non-neuronal cells in the CNS (maintain homeostasis, form myelin and provide support/ protection) e.g. schwann cells, oligodendoryctes, astrocytes, ependymal cells
410
What are the three main types of glioma? (most to least malignant)
Astrocytoma Oligodendroglioma Ependymoma
411
How are gliomas graded?
From 1-4 1= most benign 4= Most malignant
412
What is the most malignant type of brain cancer?
Glioblastoma
413
What are meningiomas?
Tumours growing from cells of the meninges in the brain and spinal cord.
414
How bad are meningiomas/
Usually benign, but take up space and can therefore lead to raised intracranial pressure and neurological symptoms
415
Are pituitary tumours usually benign or malignant and what is their main effects?
Usually benign but can press on optic chiasm to cause bitemporal hemionopia May also cause hormone deficiencies of release excessive hormones leading to endocrine disorders
416
What is bitemporal hemianopia?
Loss of the outer half of the visual fields in both eyes
417
What are the main endocrine disorders pituitary tumours can cause?
Acromegaly Hyperprolactinaemia Cushing's disease Thyrotoxicosis
418
What are acoustic neuromas?
(Vastibular Schwannoma) Tumours of the Schwann cells surrounding the auditory nerve that innervate the inner ear.
419
Where do acoustic neuromas usually occur and are they unilateral?
Around the cerebellopontine angle and are usually unilateral
420
What are the classic symptoms of acoustic neuroma?
Hearing loss Tinnitus Balance problems
421
What are the management options of brain tumours?
Palliative care Chemotherapy Radiotherapy Surgery: Depends on grade and behaviour of tumour
422
What are the treatment options of pituitary tumours?
Trans-sphenoidal surgery Radiotherapy Bromocriptine to block prolactin-secreting sumours Somatostatin analogues to block GH secreting tumours
423
What is Huntingdon's disease?
Autosomal dominant genetic condition that causes progressive deterioration of the nervous system
424
At what age do symptoms of Huntingdon's begin to present?
30-50
425
What is the inheritance pattern of Huntingdon's?
Autosomal dominant | Trinucleotide repeat disorder: genetic mutation in the HTT gene on chromosome 4.
426
What are trinucleotided repeat disorders?
Group of disease caused by a mutation in which repeats of three nucleotides increase in copy numbers and affect the nervous system.
427
What is the main features of trinucleotide repeat disorders?
Anticipation: Where successive generations have more repeats in the gene, resulting in earlier age of onset and increased severity
428
How does Huntingdon's typically initially present?
Cognitive, psychiatric or mood problems
429
What are the physical symptoms of Huntingdon's?
Chorea Eye movement disorders Dysarthria (Speech difficulties) Dysphagia (swallowing difficulties)
430
What is chorea?
Involuntary, abnormal movements
431
How is Huntingdon's diagnosed?
Specialist genetic centre using a genetic test.
432
What are the key management steps in Huntingdon's?
``` No treatment options: MDT team Speech/ language therapy Genetic counselling Advance directive/ end of life care planning ```
433
What medicines can be used to help with the symptoms of Huntingdon's?
Ones to supress disordered movement (antipsychotics, Benzodiazepines, dopamine-depleting agents) Antidepressants
434
What is the prognosis of Huntingdons?
Life expentancy is 15-20 years after the onset of symptoms.
435
What is the usual cause of death in Huntingdon's?
``` Respiratory disease (pneumonia) Suicide ```
436
What are the differential diagnoses of headaches?
``` Tension headache Migraine Cluster headaches Secondary headaches Sinusitis Giant cell arteritis Glaucoma Intracranial haemorrhage Subarachnoid haemorrhage Anaelgesic headache Hormonal headache Cervical spondylosis Trigeminal neuralgia Raised intracranial pressure Meningitis Encephalitis ```
437
What red flags should be looked for when assessing headache?
Fever, photophobia or neck stiffness (Meningitis/ encephalitis) New neurological symptoms (haemorrhage, malignancy, stroke) Dizziness (stroke) Visual disturbance (temporal arteritis/ glaucoma) Sudden onset occipital headache ( subarachnoid haemorrhage) Worse on coughing/ straining/ bending over (raised intracranial pressure) Severe enough to wake from sleep Vomiting History of trauma Pregnancy
438
What is an important examination when assessing headache?
Fundoscopy to look for raised intracranial pressure
439
What are tension headaches?
Mild ache across forehead and around head in band like pattern
440
What are tension headaches caused by?
Muscle ache in the frontalis, temporalis and occipitalis muscles
441
What are the associated causes of tension headaches?
``` Stress Depression Alcohol Skipping meals Dehydration ```
442
How are tension headaches treated?
Basic analgesia Relaxation techniques Resolve on their own
443
What are secondary headaches?
Similar presentation to tension headaches but with clear cause
444
What may cause a secondary headache?
Underlying medical condition (infection, obstructive sleep apnoea, pre-eclampsia) Alcohol Head injury Carbon monoxide poisoning
445
What is sinusitis?
Headache associated with inflammation in the ethmoidal, maxillary, frontal or sphenoidal sinuses.
446
What is an analgesic headache?
Headache caused by long term analgesia use.
447
What is a hormonal headache?
Headache related to low oestrogen (e.g. during/ before period, menopause and pregnancy)
448
What is cervical spondylosis?
Condition caused by degenerative changes in the cervical spine. Causes neck pain and often presents with headache.
449
What are the three branches of the trigeminal nerve?
Opthalmic (V1) Maxillary (V2) Mandibular (V3)
450
What is trigeminal neuralgia?
Intense spontaneous facial pain caused by the trigeminal nerve
451
How is trigeminal neuralgia treated?
Carbamazepine
452
What is Myasthenia gravis?
Autoimmune condition that causes muscle weakness
453
What age does myasthenia graves usually present?
Women: under 40 Men: Over 60
454
What other condition does Myesthenia gravis have links to?
Thymoma (thymus gland tumour)
455
What goes wrong in Myasthenia gravis?
ACh receptor antibodies are produced by the immune system, which bind to postsynaptic neuromuscular junction receptors and block them. This prevents acetylcholine from being able to stimulate the receptor and trigger muscle contraction.
456
Why does weakness get worse with activity and better with rest in Myasthenia gravis?
More and more receptors get blocked up as the receptors are used more during muscle activity.
457
What other action do the AcH antibodies perform, making symptoms worse?
Activate the complement system, causing damage to postsynaptic membrane cells
458
How does Myasthenia gravis present?
``` (Varies drastically) Weakness that gets worse with muscle use and improves with rest: Douple vision Ptosis (eyelid drooping) Facial drooping Difficulty swallowing Jaw fatigue when chewing Slurred speech ```
459
What examinations can be done to assess Myasthenia gravis?
Repeated blinking Prolonged upwards gazing (will exacerbate diplopia on further testing) Repeated abduction of one arm 20 times will result in unilateral weakness Check for thymectomy scar Test FVC
460
How can Myasthenia gravis be diagnosed?
Testing for antibodies (ACh-R antibodies, MuSK, LRP4) CT/ MRI of thymus to look for thymoma Edrophonium test
461
What is the edrophonium test?
IV dose of edrophonium chloride given, which blocks enzymes which breakdown ACh. This will increase the level of ACh at the neuromuscular junction and briefly relieve weakness, establishing diagnosis
462
What are the treatment options for Myasthenia gravis?
Reversible acetylcholinesterase inhibitors Immunosuppression Thymectomy Monoclonal antibodies (Rituximab, Eculizumab)
463
What is the most severe complication of Myasthenia gravis?
Myasthenic crisis: acute worsening of symptoms often triggered by another illness. Can lead to respiratory failure due to muscle weakness.
464
What is Lambert-Eaton myasthenic syndrome?
Similar features to Myasthenia gravis but caused by small-cell lung cancer producing antibodies which damage voltage-gated calcium channels.
465
What is Charcot-Marie-Tooth disease?
Inherited disease that affects the peripheral motor and sensory nerves by causing dysfunction in the myelin or axons
466
What is the usualy inheritance pattern in Charcot-Marie-Tooth disease?
Autosomal dominant
467
What are the classical features of Charcot-Marie-Tooth disease?
``` High arches Distal muscle wasting Weakness in lower legs and hands Reduced tendon reflexes Reduced muscle tone Peripheral sensory loss ```
468
What are the other causes of peripheral neuropathy (other than Charcot-Marie-Tooth disease)?
``` Alcohol B12 deficiency Cancer/ chronic disease Diabetes/ drugs Every vasculitis ```
469
How is Charcot-Marie-Tooth disease?
Not treatment | Supportive management
470
What is Guillain-Barre syndrome?
Acute paralytic polyneuropathy
471
What is Guillain-Barre syndrome usually triggered by?
Infection (Campylobacter jejuni, cytomegalovirus, EBV)
472
What is the cause of Guillain-Barre syndrome?
Molecular mimcry: B cells of the immune system create antibodies against antigens on the pathogen that cause the preceding infection. These match proteins on nerve cells and may target proteins on the myelin sheath or axon of motor nerve cells.
473
How does Guillain-Barre syndrome present?
- Acute, symmetrical ascending weakness - Reduced reflexes - Peripheral loss of sensation or neuropathic pain - May progress to cranial nerves and cause facial nerve weakness
474
What is the typical disease course in Guillain-Barre syndrome?
Symptoms start within 4 weeks of preceding infection, starting in the feet and progressing upwards. Symptoms peak within 2-4 weeks, then recovery lasts months to years
475
How is Guillain-Barre syndrome diagnosed?
Brighton criteria Nerve conduction studies (reduced signals) Lumbar puncture for CSF (raised protein)
476
How is Guillain-Barre syndrome managed?
IV immunoglobulins Plasma exchange Supportive care VTE prophylaxies
477
What is the prognosis of Guillain-Barre syndrome?
80% fully recover 15% left with neurological disability 5% die
478
What are migraines?
Complex neurological condition that cause headache and associated symtpoms
479
What are the different types of migraine?
Migraine without aura Migraine with aura Silent migraine (aura but no headache) Hemiplegic migraine
480
What are the typical headache symptoms associated with migraines?
``` Last between 4-72 hours Moderate to severe intensity Pounding/ throbbing Usually unilateral Photophobia Phonophobia With or without aura Nausea/ vomiting ```
481
What is aura?
``` Visual changes associated with migraines: Sparks in vision Blurred vision Lines in vision Loss of visual fields ```
482
What is a hemiplegic migraine?
Mimic stroke: Headache with weakness on one side of the body (hemiplegia), ataxia (slurred speech, loss of coordination etc) and changes in consciousness
483
What are potential migraine triggers?
``` Stress Bright lights Strong smells Certain foods Dehydration Menstruation Abnormal sleep Trauma ```
484
What are the 5 stages of a migraine?
1. Premonitory/ prodromal stage (up to 3 days before) 2. Aura (lasting <60 mins) 3. Headache (4-72 hours) 4. Resolution 5. Postdromal/ recovery phase
485
What is the acute management of migraines?
``` Sleep Paracetamol Triptans NSAIDs Antiemetics ```
486
What are Triptans?
5HT (seretonin) receptor agonists used to abort migraines when they begin
487
What can be used as migraine prophylaxis?
Avoid triggers Certain medications (propanolol, topiramate, amitryptyline) Acupuncture B12
488
What are cluster headachers?
Severe unbearable unilateral headache, usually around the eye
489
Why are they called cluster headaches?
Come in clusters of attacks (e.g. 3-4 attacks a day for weeks/ months followed by 1-2 pain free years)
490
How long do cluster headache attacks typically last?
15 mins- 3 hours
491
Who is a typical patient presenting with cluster headaches?
30-50 year old male smoker
492
What are the symptoms of cluster headaches?
``` Severe intolerable unilateral headaches Red, swollen watering eye Pupil constriction (miosis) eyelid drooping (ptosis) Nasal discharge Facial sweating ```
493
How are cluster headachers managed?
Triptans | High flow oxygen
494
What is meningitis?
Inflammation of the meninges (brain/ spinal cord lining) due to bacterial of viral infection
495
What are the most common causes of bacterial meningitis and what kind are they?
``` Neisseria meningitidis (gram negative diploccous)--> (also known as MENINGOCOCCUS) Strep. Pneumoniae (PNEUMOCOCCUS) Neonates= Group B Streptococcus ```
496
What is meningococcal septicaemia?
When the meningococcus bacterial infection is in the bloodstream
497
What common symptom does meningococcal septicaemia cause?
Non-blanching rash
498
What is meningococcal meningitis?
When the bacteria is infecting the meninges and CSF
499
What are the typical symptoms of meningits?
``` Fever Neck stiffness Vomiting Headache Photophobia Altered consciousness Seizures (may be non-blanching rash) ```
500
How do neonates present with meningitis?
Non-specific signs: | Hypotonia, poor feeding, lethargy, hypothermia, bulgin fontanella, fever
501
What tests can be done to look for meningeal irritation?
Kernig's test: Stretching meninges to look for pain/ resistance to movement Brudzinski's test: Lifting head/ neck off bed and flexing chin to see if there is involuntary flexing of hips and knees
502
How is bacterial meningitis managed in the community?
Urgent stat injection of benzylpenicillin prior to transfer to hospital
503
How is bacterial meningitis diagnosed in hospital?
Lumbar puncture for CSF Blood tests for meningococcal PCR (low threshold for treatment)
504
How is bacterial meningits treated in hospital?
<3 months: Cefotaxime + amoxicillin >3 months Ceftriaxone Vancomycin if there is risk of penicillin resistant infection Steroids to reduce severity/ frequency of hearing loss/ neurological damage Dexamethasone
505
Who should be told about bacterial meningitis/ meningococcal infection?
Notifiable diseases so public health needs to be notified
506
What is given to people who have been in contact with a meningitis patient within 7 days of the illness onset?
Post exposure prophylaxis with ciproflocaxin
507
What are the most common causes of viral meningitis?
Herpes simplex Enterovirus Varicella zoster virus (VZV)
508
Is Viral meningitis worse or better than bacterial and how is it treated?
Milder and often only requires supportive treatment
509
What is a lumbar puncture?
Inserting a needle into the lower back to collect a sample of CSF
510
What can be analysed for in CSF sample?
``` Bacterial culture Viral PCR Cell count Protein Glucose ```
511
What are the characteristics of CSF in a bacterial infection?
``` Cloudy High protein count (Bacteria release them) Low glucose (bacteria use it up) High white cell count (neutrophils) Bacterial culture ```
512
What are the characteristics of CSF in a viral infection?
``` Clear Normal protein count Normal glucose High white cell count (lymphocytes) Negative culture ```
513
What are the key complications of meningitis?
Hearing loss Seizures/ epilepsy Cognitive impairment/ learning disability Memory loss Focal neurological deficits( (limb weakness, spasticity)
514
What is encephalitis?
Inflammation of the brain (can be infective or non-infective)
515
What is the most common cause of encephalitis?
Viral- Herpes simplex virus | VZV, EBV, Influenza
516
How does encephalitis present?
``` Altered consciousness Altered cognition Unusual behaviour Acute onset of focal neurological symptoms Acute onset of focal seizures Fever ```
517
How is encephalitis diagnosed?
``` Lumbar puncture (for viral PCR) CT scan MRI EEG recording Swabs HIV testing ```
518
How is encephalitis managed?
``` IV antivirals (e.g. Aciclovir) Repeat lumbar puncture to ensure successful treatment ```
519
What are the main complications of encephalitis?
``` Lasting fatigue Change in personality/ mood/ memory/ cognition Learning disability Headaches Chronic pain Movement disorders Sensory disturbance Seizures Hormonal imbalance ```
520
What is the most common cause of dementia?
Alzheimer's disease
521
What is dementia?
Syndrome associated with progressive decline of brain function, including memory, language and problem-solving abilities
522
What might dementia symptoms include?
``` Memory loss Slow processing Language/ speaking problems Problems with understanding/ judgement Mood changes Difficulty doing daily activities Hallucinations ```
523
How common is dementia?
1 in 6 people over 80 has it
524
What are the different types of dementia?
``` Alzheimer's Vascular dementia (Combination/ Mixed) Lewy body Frontotemporal ```
525
What are most causes of dementia associated with?
Abnormal build-up of proteins in the brain, causing neurones to lose function and ultimately die, causing areas of the brain to shrink
526
What causes Alzheimer's?
Abnormal build up of two proteins: amyloid and tau
527
What does builup of amyloid do in the brain?
Deposits as plaques around brain cells
528
What do deposits of tau form. inthe brain?
Tangles
529
What does Alzheimer's do to neurotransmitter levels?
Decreases, especially ACh
530
What are the risk factory for Alzheimer's?
``` Increasing age Family history Untreated depression Cardiovascular disease risk factors (e.g. smoking, obesity, diabetes) Down's syndrome Head injuries ```
531
How is Alzheimer's diagnosed?
Rule out other causes Questionnaires/ memory / mental ability tests CT/ MRI
532
What can worsen the symptoms of dementia?
Infections Stroke Delirium Certain medicines
533
What are the 3 main stages of Alzheimer's?
``` Early symptoms (memory lapses) Middle-stage symptoms (Worsening memory with changes to behaviour) Later symptoms (increasingly severe symptoms, including hallucinations and delusions) ```
534
What medicines can be given to help manage alzheimer's?
Acetylcholinesterase (AChE) inhibitors: Increase levels of acetylcholine Memantine: Blocks effects of excessive glutamate
535
What is BPSD?
``` Behavioural and psychological symptoms of dementia: e.g. Increased agitation Anxiety Wandering Aggression Delusions/ hallucinations ```
536
What can be given to reduce symptoms of BPSD?
Coping strategies Antipsychotics Antidepressants
537
What is the second most common type of dementia?
Vascular dementia
538
What is vascular dementia?
Dementia caused by reduced blood flow to brain
539
What causes vascular dementia?
Subcortical vascular dementia/ small vessel disease (narrowing of small blood vessels in brain) Stoke (single-infarct dementia) Multi-infarct dementia (Multiple TIA's)
540
What are the risk factors for vascular dementia?
``` Hypertension Smoking Poor diet High cholesterol Lack of exercise Obesity Diabetes Excess alcohol Atrial fibrillation ```
541
What is mixed dementia?
Dementia caused by a combination of Alzheimer's and vascular dementia
542
What are Lewy bodies?
Tiny clumps of protein (alpha-synucein)
543
What is Lewy body dementia?
Dementia caused by a build up of Lewy bodies in the brain, damaging the way cells work and communicate with each other causing them to die
544
What condition is Lewy body dementia associated with?
Parkinson's disease
545
What is frontotemporal dementia?
Dementia caused by abnormal clumping of proteins (e.g. tau) in the frontal and temoral lobes, causin the death of cells and shrinking of the brain
546
What age is frontotemporal dementia usually diagnosed?
45-65
547
What are the 3 main symptoms of frontotemporal dementia?
Behavioural issues Progressive aphasia Semantic dementia (Loss of vocabulary/ understanfing)
548
What is paraplegia and what is the cause?
Paralysis of both legs, always caused by spinal cord lesion
549
What is hemiplegia and what is the cause?
Paralysis of one side of the body, caused by lesion of the brain
550
What does sensory loss usually indicate?
Spinal cord disease
551
What are the three main spinal cord tracts, what do the carry and where to they decussate?
Corticospinal: Motor tract that decussates at the medulla Dorsal colum: Sensory tract (proprioception, vibration, discrimination) that decussates at the medulla Spinothalamic: Sensory tract (pain, temperature) that decussates in the spinal cord
552
What are upper motor neurone signs?
Signs that are contralateral to the lesion, indicating that the lesion is above the anterior horn cell (in the spinal cord, brainstem and motor cortex)
553
What main signs do upper motor neurone lesions cause?
Spasticity (increased muscle tone) Weakness Hyperreflexia
554
Why does an UMN lesion cause spasticity/ hyperreflexia?
Spinal reflex activity is tightly regulated by the brain, and when inhibitory control is lost there is hyperexcitability of the spinal reflexes.
555
What are lower motor neurone signs?
Signs that are ipsilateral to the lesion, indicating it is in the anterior horn cell or distal to it
556
What are the signs of a lower motor neurone lesion?
``` Decreased muscle tone Atrophy (wasting) Fasciculations (spontaneous involuntary twitching) Weakness Reduced/ absent reflexes ```
557
Where is there weakness of in LMN disease?
Muscles supplied by involved cord segment, nerve root, part of plexus or peripheral nerve.
558
What is spondylolisthesis?
Lower back pain caused by slippage of one vertebra over the one below.
559
What is spondylosis?
Degenerative disc disease (type of arthritis)
560
What is myelopathy?
Injury to the spinal cord caused by severe compression
561
What is Radiculopathy?
Compression of a nerve in the spine.
562
What does myelopathy cause?
Upper motor neurone signs: spasticity, weakness, hyperreflexia
563
What does radiculopathy cause?
Lower motor neuron signs: decreased tone, wasting, weakness Pain down dermatome supplied by root Weakness in myotome supplied by root
564
What are the Myotomes?
Group of muscles that a single spinal nerve innervates
565
What are dermatomes?
Area of skin that a single nerve innervates
566
What are the dermatomes of the head supplied by?
Branches. of the trigeminal nerve
567
What does C5 spinal nerve control?
``` Shoulder abduction (shrug) Bicep jerk ```
568
What does C6 spinal nerve control?
Elbow flexion/ supinator jerk
569
What does C7 spinal nerve control?
Elbow extension/ tricep jerk
570
What does L3/4 spinal nerve control?
Knee extension/ jerk
571
What does L5 spinal nerve control?
Ankle dorsiflection (upwards)
572
What does S1 spinal nerve control?
Ankle planter flexion (downwards)
573
What does myelopathy (spinal cord compression) cause?
Upper neurone signs and symptoms dependent on where the compression is.
574
What is the main cause of spinal cord compression?
Vertebral body neoplasms- spinal metastases from breast, prostate and lung cancer
575
What are other common causes of spinal causes?
Vertebral body neoplasm Disc herniation Disc prolapse
576
What are intervertebral discs?
Fibrocartilagenous joint that allows slight movement, ligaments that hold the vertebrae together and acts as a shock absorber to the spine.
577
What is disc herniation?
When the centre of the disc (pulposus) moves out through the outer part (annulus), causing pressure on the nerve root and pain
578
What is disc prolapse?
When the nucleus pulposus (middle of dic) moves and presses against the annulus but doesn;t escape, producing a bulge in the disc which can put pressure on the nerve root and cause pain.
579
What symptoms does a slipped disc cause? (prolapse or herniation)?
- Lower back pain - Numbness - Tingling (paraesthesia) - Paraplegia - Problems bending/ straightening - Muscle weakness - Sensory loss below level of lesion
580
Which is worse- disc prolapse or herniation?
Herniation
581
What are rarer causes of spinal cord compression?
Infection Haematoma Primary spinal cord tumour
582
What are the red flag signs in spinal cord compression?
Loss of bladder/ bowel function UMN signs in the lower limbs (spasms, hyperreflexia) LMN signs in upper limbs (atrophy)
583
What investigations can be done to look for spinal cord compression?
X-ray whole spine MRI if indicated Renal function Haemoglobin to monitor blood less
584
How is spinal cord compression treated?
Dexamethasone until treatment plan confrimed Catheterisation + Analgesia Surgical decompression or chemotherapy as indicated.
585
What is sciatica?
Compression of the sciatic nerve (usually caused by a herniated disc) at L5/S1, causing pain, numbness and weakness along the sciatic nerve (lower back, buttocks, leg)
586
What is the cauda equina?
Sack of nerve roots that extend from the bottom of the spinal cord
587
Where does the spinal cord end?
L1-L2
588
What is cauda equine syndrome?
When there is compression on the cauda equina
589
What causes cauda equina syndrome?
``` Spinal damage at or caudal to L1, caused by: Herniated disc (usually around L5) Tumour Infection Fracture/ trauma Spondylolistesis ```
590
What is the main difference in presentation between cauda equina and lesions higher up the spinal cord?
Leg weakness is flaccid and reduced/ absent reflexes (instead of spastic and hyperreflexic)
591
How does cauda equina present?
``` Bilateral sciatica Saddle anastesia Bladder/ bowel dysfunction Erectile dysfunction Variable leg weakness (flaccid and areflexic) ```
592
How is Cauda Equina diagnosed?
Rectal exam: loss of anal tone/ sensation MRI spine Knee, ankle flexion tests Straight leg raising, femoral stretch test
593
How is cauda equina treated?
Surgical decompression Immobilise spine Anti-inflammatories Chemotherapies if needed
594
What is apraxia?
Inability to perform learned/ familiar movement on command, despite willingness to perform the task.
595
What is the action of the precentral gyrus?
Primary motor cortex- responsible for executing voluntary movements
596
What are the steps in the organisation of movement?
1. Idea of movement (in various areas of cortec) 2. Activation of upper motor neurones in pre central gyrus 3. Impulses travel to lower motor neurones via corticospinal tract 4. Cerebellum and basal ganglia modulate activity
597
What is a motor unit?
The basic functional unit of muscle activity: an alpha motor neurone (LMN) + axon + the skeletal fibres it innervates
598
What regulates muscle tone?
Stretch receptors in muscle (muscle spindles) innervated by gamma motor neurones. Regulated by local spinal cord reflexes
599
What is muscle tone?
The maintenance of partial contraction of a muscle, important for generating reflexes, maintaining posture and balance, and controlling proper function of other organ systems.
600
What are the potential sites of damage along the motor pathway?
``` Motor nuclei of cranial nerves Motor neurones in spinal cord Spinal ventral roots Peripheral nerves Neuromuscular junction Muscle ```
601
What are upper motor neurone signs?
``` Everything goes up!: Spasticity (increased muscle tone) Brisk reflexes Plantars upturned on stimulation Limb muscle weakness in characteristic pattern ```
602
What is a positive Babinski sign?
Plantars upturned on stimulation
603
What is the characteristic limb muscle weakness in upper motor neurone disease?
Upper limb extensors weaker than flexors Lower limb flexors weaker than extensors Impaired finer movement
604
What are lower motor neurone signs?
``` Everything goes down!: Flaccid (reduced muscle tone) Muscle wasting Fasciculation (spontaneous contractions) Depressed/ absent reflexes ```
605
What are the 6 mechanisms that can cause nerve malfunction?
``` Demyelination Axonal degeneration Compression Infarction Infiltration Wallerian degeneration ```
606
What does demyelination cause and what is an example?
Marked slowing of conduction (e.g. Guillain-Barre syndrome)
607
What is Wallerian degeneration?
Process that results when a nerve fibre is cut or crushed, and the part of the axon distal to the injury degenerates.
608
What are the different types of peripheral nerve disease?
Neuropathy Mononeuropathy Mononeuritis multiplex Polyneuropathy
609
What is mononeuritis multiplex?
When 2 or more individual nerves are affected
610
What is a polyneuropathy?
When many nerves in different parts of the body are involved (can be sensory, motor or both)
611
What is the usually cause of a mononeuropathy?
Local cause: trauma or entrapment (e.g. tumour)
612
What are the causes of mononeuritis multiplex?
``` Wegener's granulmatosis Aids/ Amyloid Rheumatoid arthritis Diabetes mellitus Sarcoidosis Polyarteritis nodosa Leprosy Carcinoma ```
613
What is the most common mononeuropathy?
Carpal tunnel syndrome
614
What happens incarpal tunnel syndrome?
Pressure and compression. onthe median nerve as it passes through the carpal tunnel in the wrist.
615
What is the cause of carpal tunnel syndrome?
Idiopathic | Associated with hypothyroidism, diabetes, pregnancy, amyloidosis, obesity, RA and acromegaly
616
What are the symptoms of carpal tunnel syndrome?
Ache in fingers, hand or arm (worse at night) Numb hands Tingling/ pins and needles (Paraesthesiae) Weak thumb (symptoms are intermittent and progressive)
617
How can carpal tunnel syndrome be managed?
Wrist splint (relieves pressure on nerve) Stop things that trigger it (e.g. vibrating work tools, playing an instrument) Painkillers Surgery
618
Where does the median nerve arise and what is its main action?
C6-T1 (Brachial plexus) | Precision grip
619
What muscles are innervated by the median nerve?
``` LOAF: 2 Lumbricals Opponens pollicis Abductor pollicis brevis Flexor pollicis brevis ```
620
Where does the ulnar nerve arise and what is its main actions?
C7-T1 (Brachial plexus) | Responsible for flexing at the elbow
621
Where does the radial nerve arise and what is its main actions?
C5-T1 | Opening the fist
622
What are the most common nerve mononeuropathies?
``` Median Ulnar Radial Sciatic Tibial Phrenic Peroneal ```
623
What are the 3 categories of peripheral nerve injuries?
Stretch related, lacerations, compressions
624
How can polyneuropathies be classified?
``` By course (acute or chronic) By function (sensory, motor, autonomic or mixed) By pathology (demyelination, axonal degeneration, both) ```
625
What are the causes of polyneuropathies?
``` Metabolic Vasculitides Malignancy Inflammatory Infections Nutritional (deficiencies) Inherited syndromes Drugs/ toxins ```
626
What are the metabolic causes of polyneuropathy?
Diabetes Renal failure Hypothyroidism Hypoglycaemia
627
What is the clinical presentation of a sensory polyneuropathy?
Numbness Pins & needles Glove and stocking distribution
628
What are the clinical presentations of a motor neuropathy?
``` Often progressive Weak/ clumsy Difficult walking or breathing Wasting/ Reduced/ absent reflexes ```
629
Where are the cranial nerve nuclei located?
Brainstem (medulla, pons and midbrain)
630
What can cause cranial nerve lesions?
``` Brainstem problems: Tumour MS Trauma Aneurysm Vertebral artery dissection (infarction) Infection ```
631
What happens in a CN3 palsy?
Oculomotor: Ptosis (drooping eyelid) Fixed dilated pupil Eye down and out
632
What happens in a CN4 palsy?
Trochlear nerve: | Innervates superior oblique so results in a head tilt to correct extortion
633
What happens in a CN6 palsy?
Abducens: | Innervates the lateral rectus eye muscle so eye is adducted
634
What happens in a CN5 palsy?
Trigeminal nerve: Jaw deviation Loss of corneal reflex
635
What happens in a CN7 palsy?
Facial nerve: | Facial droop and weakness
636
What happens in a CN8 palsy?
Vestibulocochlear nerve: Hearing impairment Vertigo/ lack of balance
637
What happens in a CN9/10 palsy?
Glossopharyngeal/ vagus: Gag reflex and swallowing issues Vocal issues
638
What is autonomic neuropathy?
Damage to the nerves that control involuntary bodily processes (e.g. digestion, bladder function, blood pressure)
639
How might autonomic neuropathy present?
``` Postural hypotension (faint on standing) Ejaculator failure Reduced sweating Erectile dysfunction Constipation Nocturnal diarrhoea Urine retention ```
640
What is the Purkinje layer of the cerebellum?
The outer layer, that is the only area of output.
641
What is syncope?
Temporary loss of consciousness due to disruption of blood flow to the brain
642
What causes a vasovagal episode (fainting)?
Problem with the autonomic system regulating blood flow to the brain: When the vagus nerve receives a strong stimulus (e.g. emotional event, change in temperature), it can stimulate the parasympathetic nervous system. This dilates the vessels in the brain, reducing the pressure in the cerebral circulation and leading to hypoperfusion.
643
What is the prodome?
The feeling prior to fainting which may involve feeling: - Hot/ clammy - Sweaty - Heavy - Dizzy/ lightheaded - Dark/ blurry vision - Headache