Neuro Flashcards
MCC of SAH
rupture of berry aneurysm
MC location for berry aneurysm
Middle Cerebral artery
Give this stroke location:
Major deficit is in the LLE w/ minimal LUE involvement and no involvement of the face
R anterior cerebral artery
Name the location for this stroke:
Pt presents with diplopia, CNS dysfxn, ataxia, vertigo, & BL motor & sensory changes
Vertebrobasilar artery
Give this stroke location:
Pure motor stroke on the CONTRALATERAL side of the lesion, pure sensory stroke CONTRALATERAL to the lesion, & clumsy-hand dysarthria
Lacunar stroke
Patient cannot identify friends and family around them
agnosia
patient loses the ability to perform basic math fxns
Acalcula
What type of memory loss is most pronounced in a pt w/ Alzheimer’s dz?
recent memory
What type of protein deposits occur in the brain of a pt w/ Alzheimer’s dz?
beta amyloid deposits
MC ophthalmologic problem that is seen w/ MS
optic neuritis
What is the underlying infxn in a pt w/ Ramsay Hunt Syndrome?
Herpes zoster
Paralysis or weakness of the muscles supplied by the FACIAL N., typically occurs UNILATERALLY, & is due to inflammation & swelling of the facial n.
Bell’s palsy
What autoimmune dz has a destruction of myelin & or axons by anti-ganglioside Abs?
Guillain-Barre Syndrome (GBS)
What is the most frequent cause of peripheral neuropathy in the developed world?
DM
Dz assoc. w/ ptosis, diplopia, dysphonia, PROXIMAL LIMB WEAKNESS, DYSPHAGIA, & respiratory weakness
Myasthenia gravis
What reflex is initially affected by the polyneuropathy in DM?
Achilles
This is a demyelinating dz of PERIPHERAL NERVES that causes an acute progressive weakens, usu as an ASCENDING PARALYSIS
Guillain-Barre Syndrome (GBS)
This is a disorder of NEUROMUSCULAR JXN resulting in pure motor sx w/ WEAKNESS & FATIGUE
Myasthenia Gravis
What condition does the following medications tx: Zomig, Amerge, Maxalt, Frova, & Relpax?
Migraine HA (these are ALL triptans)
Type of HA that is severe, UNILATERAL, & located in the periorbital area & temple that is assoc. w/ IPSILATERAL LACRIMATION, rhinorrhea, ptosis, miosis, & nasal congestion
Cluster HA
W/o medication, the MC way a migraine HA’s pain is terminated…
sleep
3 hormones that are thought to result in migraine HAs
- serotonin (biggest role)
- dopamine
- NE
2 foods known to cause migraine HA
- Aged cheese
2. wine
This type of HA is MCly described as dull, pressing, or BAND-LIKE that occurs upon arising or shortly thereafter
Tension HA
Category of medication that triptans occur
5HT-1 agonists (serotonin agonists)
This HA has pain in the OCCIPITO-FRONTAL areas of the heal along w/ tenderness of the neck & scalp muscles
Tension HA
What psychiatric condition is commonly present in those w/ daily HA or tension HA?
depression
MCC of endemic encephalitis that is related to a virus
HSV 1 & 2
MC enterovirus causing encephalitis
Coxsackie B
Medication of choice for treating HSV encephalitis
Acyclovir IV
2 MCCs of neonatal bacterial meningitis
- Grp B & D strep
2. E coli
2 MCCs of adult onset bacteral meningitis
- Strep. pneumoniae
2. H. influenzae
What is the ONLY neurodegenerative dz that is treatable long-term?
Parkinson’s dz
Abx TOC for bacterial meningitis in those 0-4 wks of age
Ampicillin + 3rd gen cephalosporin (ex. Rocephin)
This condition involves an involuntary repetitive contraction of agonist & antagonist muscles producing rhythmic oscillation around a joint at a regular frequency
Tremor
MC condition resulting in a resting tremor
Parkinson’s dz
TOC for MS
Immunomodulating meds such as INTERFERON
What MAO B inhibitor is MCly used in the mgmt of Parkinson’s Dz?
Selegine (Eldeprel)
-reversible w/ d/c of tx
The medication Tolcapone use in the mgmt of Parkinson’s dz belongs to what class?
COMT inhibitor (catechol-o-methyl transferase) - it reduces peripheral metabolism of levodopa permitting increased brain concentration of levodopa
The agents Pramipexole & Ropinirole use in the tx of Parkinson’s dz & RLS belong to what classification?
Dopamine agonists
Sinemet is a combination of:
levodopa & carbidopa
Anticholinergics used in the tx of Parkinson’s dz have their best activity against what Parkinson’s sxs?
tremor & rigidity
This is an inherited dz characterized by DEMENTIA & CHOREA that has a gradual onset & SLOW PROGRESSION
Huntington’s dz
Medication of choice used for dyskinesia &/or behavioral problems due to Huntington’s dz?
Haloperidol (Haldol)
This is a recurrent, inflammatory progressive DEMYELINATION OF WHITE MATTER of the brain & spinal cord resulting in multiple & varied neurologic s/sx
Multiple Sclerosis (MS)
What imaging technique is considered to the the gold standard for identifying MS?
Gadolineum enhanced MRI
Radiofrequency rhizotomy is used for what condition?
Trigeminal neuralgia
Drug TOC for relapsing MS
Beta interferon, Copolymer (Copaxone)
TRANSIENT DISTURBANCE of cerebral fxn due to PAROXYSMAL DISCHARGE in the brain
seizure
3 types of generalized seizures
- Absence (petit mal)
- Myoclonic
- Tonic-clonic (grand mal)
2 types of partial seizures
- simple
2. complex
Type of seizure that is MCly assoc. w/ automatisms
Complex partial seizures
Name this seizure:
Pt. has impaired consciousness, sometimes w/ mild, clonic, tonic, or atonic components such as reduction or loss of postural tone
Absence (petit mal)
Abrupt onset of HA assoc. w/ STIFF NECK & PHOTOPHOBIA & may have the development of focal neurologic deficits is usu due to
Cerebral aneurysm
Gold standard diagnostic study for evaluation of a cerebral aneurysm
cerebral angiogram
Imaging modality of choice used in the evaluation of a cerebral aneurysm
non-contrast CT
What is the biggest risk factor for TIAs affecting the small, deep vessels of the brain (lacunar strokes)?
HTN
Name the 3 most important PE findings that are most specific to stroke syndromes
- Facial paralysis
- Arm drift
- AMS
What biochemical markers may be found in a pt who has an intracranial hemorrhage?
Matrix metalloproteinases (MMP) & cellular fibronectin - both are elevated in hemorrhage
3 MCCs of death in the US
- CAD
- cancer
- stroke
Name the condition with the following assoc. sx:
sudden weakness or numbness one one side of the face or body; sudden confusion, trouble speaking or understanding; sudden trouble seeing in one eye; sudden trouble w/ walking, dizziness, loss of balance or coordination; & sudden severe HA w/o cause
stroke
DOC for trigeminal neuralgia
Oxycarbazepine (Trileptal)
2 main causes of hemorrhagic stroke
- intracerebral hemorrhage
2. subarachnoid hemorrhage
Imaging study of choice in the initial evaluation of a pt suspected of having a stroke
non-contrast CT
Time frame in which thrombolytics can be given to a pt w/ an ischemic stroke
w/in 3 hrs of sx
What medication is considered to be the first-line agent to reduce stroke recurrence in pts who have prvious cardiac dz
Aggrenox (combination of dypridamole & Aspirin)
preferred agent of choice for stroke prevention in a pt who is at high risk for a stroke & who has a-fib
warfarin (coumadin)
2 non-antiplatelet medication classes that have been used as modifying risk factors for stroke
statins & ACE inhibitors combined w/ diuretics
sudden loss of muscle strength/tone w/ sudden LOC, immediate recovery after lasting only a few seconds
Atonic seizures
spike & wave pattern on EEG at 3 per second is classically seen w/ what type of seizure?
Absence seizure
Gold standard tx for pts w/ myoclonic seizures
Valproic acid (Depakote)
Type of seizure that is MCly assoc. w/ automatisms
complex partial seizures
part of the brain that is MCly assoc. w/ atonic seizures
Corpus callosum
MCC of status epilepticus
abrupt stoppage of antiepileptic medications