Neural Tube Defects Flashcards
What are the three types of cells in a fetus?
- ectoderm- NS, skin, teeth
- mesoderm- blood vessels, muscles, bones
- endoderm- GI, GU, pulm system
What happens during weeks 4-5 of the fetal development?
heart begins, neural tube, eyes and ears, limb buds, rapid brain/head growth, bronchi
When is the neural plate formed?
formed by day 18
What are the two different parts of the neural plate?
- neural tube- CNS, Brain, SC
2. neural crest- PNS, CN, spinal nerves, ANS, ganglia
When does the neural ectoderm close and what are two different types of processes?
26-28 days
- neurilation- cranial
- canalization- caudal
What is spinal dysraphism?
term to describe congenital abnormalities that include defects of the vertebrae, spinal cord or root
What is spina bifida occulta?
non fusion but there are no neural problems
What is SB cystica?
neural, vertebrae arches fail to close properly
What are two kinds of SB cystica?
- meningocele
2. myelomeningocele
What is SB cystica meningocele?
Cystic sacs with meninges and CSF
SC stays within canal but may have abnormalities
no clinical signs or may have varied
What is SB cystica myelomeningocele?
still have sacs but SC and menineges are in the sac causing sensory and motor impairments at level of lesion and below
also area of damage is exposed
What is the cause of SB?
genetics, teratogens, nutritional deficits
What are risk factors for SB?
previos NTD pregnancy, maternal insulin dept DM, Sz meds, lower SES, obesity
What are common clinical presentations of SB?
absesnse of sensory or motor function at and below lesion Bilaterally
loss of neural control of bowel and bladder
What are common complications with SB?
CNS- hydrocephalus, arnold chiari malformation
MS
multisystem- latex allergy, obesity, osteoporosis, skin breakdown
What are symptoms of hydrocephalus?
increased ICP, sunsetting of eye, bulging fontanelle, VS instability
What is a Arnold Chiari II malformation?
cerebellar hypoplasia, caudal displacement of cerebellum and medulla through foramen magnum
What are sx of ACM II?
stridor, apnea, GE reflux, paralysis of vocal cords, swallowing problems
What are signs of progressive neurological dysfunction?
changes in spasticity, strength, sensation and pain, scoliosis, changes in bowel/bladder sphincter control
What is the cause of PND?
tethered cord syndrome- scarring of neural cord to overlying dura or skin- produces traction on neural structures
What are other related CNS complications with SB?
vision, perceptual motor, communication, dev. delays
What factors attribute to MS complications?
muscle imbalance, PND, intrauterine position, deformities after fracture
When should patients with SB have follow up exams with PT?
every 6 months until 24 months old then annually through adulthood
Why is strength testing so important for SB pts?
loss of strength could be indicative of PND
What are LE strength predictors for ambulation?
0-3 iliospsoas strength - partial or complete w/c use
4-5 iliopsoas and quad- community ambulation
4-5 gluteal and anterior Tib, community ambulation with no AD or orthosis
What are factors that will affect outcomes in SB pts?
motor level, age, cognition, body proportions, sensation, orthopedic complications, UE function, spasticity
What is the major focus of PT?
minimize impact or and development of bony deformities,postural changes and abnormal tone/strength
What are most important interventions during infancy?
family education, positioning, mobility, postural control
What are most important interventions during childhood?
mobility, transfers, ambulation and fitness
What are most important interventions during adolescence?
functional changes, equipment for mobility, self management, fitness
What are common complaints in adult SB pts?
obesity, incontinence, recurrent UTI, joint pain, HTN, depression, social integration
What is most common cause of morbidity of SB?
UTI
What is a reciprocating gait orthosis indicated?
L1-L3 motor level need some HF
When is a HKAFO indicated?
need support for weak hip
When is a KAFO indicated?
L3-4, if weak at knee, absent ankle ms, if unstable knee
What is a AFO indicated?
L4-S1, weak or absent ankle ms but atlas 4/5 knee extension
When is supramaleolar orthotics indicated?
shoe insert with support at ankle, S1