Neural Tube Defects Flashcards
What are the three types of cells in a fetus?
- ectoderm- NS, skin, teeth
- mesoderm- blood vessels, muscles, bones
- endoderm- GI, GU, pulm system
What happens during weeks 4-5 of the fetal development?
heart begins, neural tube, eyes and ears, limb buds, rapid brain/head growth, bronchi
When is the neural plate formed?
formed by day 18
What are the two different parts of the neural plate?
- neural tube- CNS, Brain, SC
2. neural crest- PNS, CN, spinal nerves, ANS, ganglia
When does the neural ectoderm close and what are two different types of processes?
26-28 days
- neurilation- cranial
- canalization- caudal
What is spinal dysraphism?
term to describe congenital abnormalities that include defects of the vertebrae, spinal cord or root
What is spina bifida occulta?
non fusion but there are no neural problems
What is SB cystica?
neural, vertebrae arches fail to close properly
What are two kinds of SB cystica?
- meningocele
2. myelomeningocele
What is SB cystica meningocele?
Cystic sacs with meninges and CSF
SC stays within canal but may have abnormalities
no clinical signs or may have varied
What is SB cystica myelomeningocele?
still have sacs but SC and menineges are in the sac causing sensory and motor impairments at level of lesion and below
also area of damage is exposed
What is the cause of SB?
genetics, teratogens, nutritional deficits
What are risk factors for SB?
previos NTD pregnancy, maternal insulin dept DM, Sz meds, lower SES, obesity
What are common clinical presentations of SB?
absesnse of sensory or motor function at and below lesion Bilaterally
loss of neural control of bowel and bladder
What are common complications with SB?
CNS- hydrocephalus, arnold chiari malformation
MS
multisystem- latex allergy, obesity, osteoporosis, skin breakdown