Neural Pathology

Question 1

What are the C’s of Huntington’s disease

Answer 1

1) CAG repeats on Chromosome 4
2) decrease in ACh (and GABA)
3) Caudate Nucleus
4) Chorea
5) presents around age 40
6) Cognitive decline

Question 2

Huntington’s disease is atrophy of what parts of the brain?

Answer 2

Patients with Huntington’s disease have atrophy of the caudate and putamen, representing degeneration of the GABAergic and cholinergic neurons located there.

AD trinucleotide expansion disorder (CAG repeats)

S/S: chorea, cognitive decline, and behavioral disorders

treatment includes: benzos (for chorea), valproic acid, reserpine, or tetrabenazine

Question 3

Atrophy of the substantia nigra

Answer 3

Parkinson