Nervous system: Synapses Flashcards
synapse
anatomically specialised junction between two neurones
can converge or diverge
0.2ms
excitatory synapse
generate excitatory post synaptic potential: membrane potential of post-synaptic neuron is brought closer to threshold (i.e., depolarised). graded potential generated
inhibitory synapse
generate an inhibitory postsynaptic potential: membrane potential of post-synaptic is either driven further from threshold (i.e., hyperpolarised) or stabilised at resting potential
made more negative
electrical synapse
electrical activity of the presynaptic neurone affects that of the postsynaptic neuron
pre and post synaptic cells connected by gap junctions
chemical synapse
neurotransmitters transmit the signal
active zones
release regions in which vesicles are docked on the presynaptic membrane
types of receptors in post synaptic neurone
ionotropic (ion channels)
metabotropic (G protein/second messenger signalling)
removal of neurotransmitter
diffusion of transmitter from cleft
degradation of neurotransmitter by enzymes
reuptake into presynaptic cells for re use
why are multiple excitatory postsynaptic potentials needed
one=0.5mV
need a change of 15mV
not enough to reach threshold
temporal summation
repeated stimulation of one neurone
spatial summation
multiple neurones activated simultaneously to produce graded potentials
inhibitory synapses can also do this
muscle spindle
stretch receptors consist of peripheral endings of afferent nerve fibers wrapped around modified muscle fibers enclosed within a connective tissue capsule
intrafusal fibres
specialised muscle fibres to detect changes in stretch
extrafusal fibres
generate force, bulk of muscle
what does tension depend on
muscle length
load
fatigue