Nervous System/Hearing Flashcards
Neuron
single cell w/dendrite, soma, axon hillock, axon (myelin, nods of Ranvier)
*cannot change size of action potentials it transmits
Nerve
bundle of many different axons from different neurons
Soma
central body of the neuron
contains the nucleus
Axons
carry info away from soma
Myelin Sheath
allow for saltatory conduction
no ions can enter or exit neural axon that’s myelinated
dramatically speeds the movement of action potentials by forcing AP to jump from node to node
CNS - Oligodendrocytes
PNS - Schwaan Cells
Dendrite
carry info into the soma
Axon Hillock
initiates action potential
Synaptic Cleft
small gap between the presynpatic and the postsynaptic neuron
chemicals released into the space to excite the next neuron
Synaptic Knob
axons terminate in synaptic knobs
form connections with target cells
Axon Velocity Increases with
increasing myelin
increasing diameter
Na+/K+ ATPase
3 Na+ out
2 K+ in
w/hydrolysis of 1 ATP molecule
potassium leak channels
open all the time
allow some of the K+ from the cell to go out into the extracellular space (down the gradient)
Resting Membrane Potential
-70 mV
Sodium leak channels
very few
100 K+ leak channels: 1 Na+ leak channels
Are neurons the only cells with a resting membrane potential?
No. All cells have a resting membrane potential (rmp)
Neurons and muscle tissue use rmp to generate action potentials
Depolarization
sodium voltage-gated channels open (in response to membrane potential) to allow Na+ into the cell (down the gradient)
Once membrane potential reaches -50mV (threshold), all Na+ channels are opened fully
Channels are closed before threshold potential
Reaches +35 mV before inactivating Na+ channels
Threshold potential
-50 mV
Can an action potential run out of energy and not reach the other end?
Action potentials are continually renewed at each point in the axon as they travel
Assuming enough voltage-gated channels, once an action potential starts, it will propagate without a change in amplitude until it reaches a synapse
All or none response
if membrane potential doesn’t reach the threshold, the voltage-gated sodium channels won’t open up
Repolarization
- voltage-gated K+ channels open more slowly than the Na+ ones -> respond to the depolarization of the membrane
- membrane potential returns to negative because K+ ions are leaving the cells
- overshoots the resting potential, -90 mV
- K+ voltage-gated channels close
- K+ leak channels and Na+/K+ ATPase bring the membrane back to resting potential
Saltatory Conduction
rapid jumping conduction in myelinated axons
Glial cells
specialized, non-neural cells that typically provide structural and metabolic support to neurons
ex. Schwaan cells
Schwaan cells
PNS
form myelin - increase speed of conduction of APs along axon
Oligodendrocytes
CNS
form myelin - increase speed of conduction of APs along axon
Astrocytes
CNS
Guide neuronal development
Regulate synaptic communication via regulation of neurotransmitter levels
Microglia
CNS
Remove dead cells and debris
Ependymal cells
CNS
produce and circulate cerebrospinal fluid
Nernst Equation
Eion = RT/zF = ln [X]outside/[X]inside
z= valence of ion F= Faraday's constant Eion = equilibrium potential
Equilibrium potential
membrane potential at which this driving force (gradient) does not exist
no net movement of ions across membrane
chemical gradient across membranes
created by relative concentrations of ions on each side of the membrane
Electrical gradient across membranes
determined by valence (charge of ion)
Absolute refractory period
neuron will not fire another action potential no matter how strong a membrane depolarization is induced
Na+ volt-gate channels inactivated
on the way back down (at the threshold), Na+ channels are closed
Relative refractory period
neuron can be induced to transmit an action potential
requires greater depolarization (b/c its hyperpolarized)
from the point where Na+ channels closed to the point where resting membrane potential is established
Electrical synapses
occur when cytoplasm of 2 cells are joined by gap junctions not common in nervous system prominent in smooth and cardiac muscle excitatory only - depolarizes bidirectional
Chemical synapses
found at the end of axons where they meet their target cell
action potential converted into a chemical signal
synaptic cleft present
excitatory (depolarizes) or inhibitory (hyperpolarizes)
unidirectional
Steps in chemical synapses
- action potential reaches end of an axon (synaptic knob)
- depolarization of presynaptic membrane opens Ca++ voltage-gated channels
- Ca++ influx causes exocytosis of neurotransmitters stored in secretory vesicles
- Neurotransmitter molecules diffuse across the narrow synaptic cleft
- Neurotransmitters bind to receptor proteins (ligand-gated ion channels) in postsynaptic membrane
- Opening the ion channels alters membrane polarization
- if threshold is reached, Na+ voltage-gated channels are opened => action potential is initiated
- Neurotransmitter in the synaptic cleft is degraded/removed to terminate the signal
Neurotransmitter Breakdown
reuptake
enzyme (ex. acetylcholinesterase)
glial cells (astrocytes)
Each presynaptic neuron can only___
postsynaptic neuron can respond to ____
release one type of neurotransmitter
respond to many different neurotransmitters
If an inhibitor of acetylcholinesterase is added, what happens to the postsynaptic membrane?
it will be depolarized longer w/each potential
Temporal summation
summing up synapses over time
*increased frequency of action potentials will add up to increase the number of action potentials transmitted
Spatial summation
summation over space
multiple inputs
Excitatory postsynaptic potentials (EPSPs)
excitatory neurotransmitters cause postsynaptic depolarization
Inhibitory postsynaptic potential (IPSPs)
inhibitory neurotransmitters cause postsynaptic hyperpolarization
Peripheral Nervous System (PNS)
receiving info = sensory function
acting on the info = motor function
all nerves and sensory structures outside of the brain and spinal cord
Central Nervous System (CNS)
processing info = integrative function
brain and spinal cord
Motor neurons (PNS)
carry info from nervous system to the organs
efferent neurons = exit CNS