Nervous System and Endocrine System Flashcards
exocrine gland
- secrete into a duct that carries the secretion to the body surface/body cavities
eg. sweat glands, mucous glands, salivary glands
endocrine gland
- secrete hormones into the extracellular fluid that surrounds the cells that make up the gland
- usually passes into capillaries to be transported by blood
eg. pinel, thyroid, parathyroid, pancreas, testes, ovaries, adrenal, thymus, hypothalamus
hormones
- proteins, steroids or amines
- may affect all cells of the body or only particular groups (target cells) or particular organs (target organ)
protein/amine hormones
- work by attaching to receptor proteins in the membrane of the target cell
- hormone and receptor combining causes secondary messengers substance to diffuse through a cell and activate particular enzyme
- lock and key
- limited # of receptors in each membrane
steroid hormones
- work by entering target cells and combining with a receptor protein inside the cell
- may be in mitochondria/nucleus
- hormone-receptor complex activates the genes controlling the formations of particular proteins
hormones may…
- activate certain genes in the nucleus so that a particular enzyme or structural proteins is produced
- change in shape or structure of an enzyme so that is is turned ‘on’ or ‘off’
- change the rate of production of an enzyme or structural protein by changing the rate of transportation or translation during protein production
enzyme amplification
- a series of chemical reactions in which the product of one step is an enzyme that produces an even greater number of product molecules
hormone clearance
- turning off hormone is done by breaking it down
- can be done in target cells, but also liver and kidney
- excreted in bile or urine
control of hormone secretions
- regulated by negative feedback systems whereby the response produced by the secretion of the hormone is the opposite of the stimulus that caused the secretion
- some involve release of regulating factors from hypothalamus/brain (regulate function of pituitary gland)
hypothalamus
- located at base of brain
- regulates many basic functions eg. body temp, water balance, heart rate
- many functions carried out through pituitary gland
- produces many hormones
- some carried by the blood to anterior lobe of the pituitary gland, where they stimulate/inhibit the release of hormones made in the anterior lobe
- others pass along nerve fibres from hypothalamus to posterior lobe of pituitary where they are then secreted
pituitary gland
- lies just under hypothalamus and is joined to hypothalamus by a stalk called INFUNDIBULUM
- vital for normal functioning
- consists of anterior and posterior lobes
anterior lobe of pituitary
- front
- no nerved connecting it to the hypothalamus but connected by complex network of blood vessels
- controlled by releasing and inhibiting factors secreted by the hypothalamus (secreted into extracellular fluids around cells of the hypothalamus and carried by blood to the anterior lobe)
posterior lobe of pituitary
- hormones not manufactured here
- produced in special nerve cells in the hypothalamus of the brain
- cells have long extensions that pass through infundibulum to posterior lobe
- hormones move down extensions and stored ready for release into bloodstream
- release of hormone triggered by nerve impulses
follicle-stimulating hormone
ovaries: growth of follicles
testes: production of sperm
luteinising hormone
ovaries: ovulation and maintenance of corpus lutem
testes: secretion of testosterone
growth hormone
all cells: growth and protein synthesis
thyroid stimulating hormone
thyroid: secretion of hormones from thyroid
adrenocorticotropic hormone
adrenal cortex: secretion of hormones from the adrenal cortex
prolactin
mammary glands: milk production
antidiuretic hormone
kidneys: reabsorption of water
oxytocin
uterus: contractions of uterus during childbirth
mammary glands: release milk
the pineal gland
- found deep inside brain
- unknown role
- secretes melatonin
melatonin
regulates sleep patterns
thyroid gland
- located in neck
- 2 lobes on either side of trachea joined by a narrow piece of tissue
- thyroxine secreted (consists of iodine and amino acids)
thyroxine
- controls body metabolism by regulating reactions in which complex molecules are synthesised from simple ones
the parathyroid glands
- embedded in the rear surface of the lobes of the thyroid gland
parathyroid hormone
- controls calcium and phosphate levels in the blood
the thymus
- located in chest, just above hear and behind sternum
- secretes thymosins (influence maturation of disease-fighting cells)
the adrenal glands
- 2 glands; one above each kidney
- each had inner adrenal medulla and an outer adrenal cortex
adrenal medulla
- produces adrenaline and noradrenaline
adrenaline
- prepares body for fight/fight
noradrenaline
- increases rate/force of heartbeat
adrenal cortex
- 20+ hormones produces
aldosterone
- acts on kidney to reduce amount of Na and increase about of K in urine
cortisol
- promotes normal metabolism
- helps body withstand stress
- repair damaged tissues
the pancreas
- lies just below stomach/alongside duodenum
- both exo and endocrine gland
- exocrine part secretes digestive enzymes into the small intestine through pancreatic duct
- islets of lagerhands are the endocrine part of pancreas
insulin
- reduces amount of glucose in blood
- promotes uptake of glucose in the blood by the cells of the body
- determines by amount of sugar in the blood and is controlled through neg feedback systems
glucagon
- increases amount of glucose in blood
- promotes breakdown of glycogen to glucose in liver
the gonads
- testes or ovaries
- produce hormones as well as eggs/sperm
androgens
- male sex hormones
- responsible for development/maintenance of male sex characteristics
oestrogens
- female sex hormones
- responsible for development/maintenance of female sec characteristics
- regulates menstruation/pregnancy changes