nervous system

Question 1

morphine

Answer 1

• drug class: opioid analgesics
• common indications: pain
• mechanism of action: strong opioid receptor agonist
• common side effects: resp depression, eyes is, GI problems, miosis, cvs problems
• uncommon side effects:
• drug-drug interactions: CNS depressant effects with many
• contra-indications: asthmatics due to histamine release, resp depression,

Question 2

cyclizine

Answer 2

• drug class: h1 receptor antagonist - anti emetic
• common indications: motion sickness, morning sickness
• mechanism of action: blocks h1 receptor so histamine can’t bind in the vestibular cochlea in the ear so no signals reach CTZ so no vomiting sensation
• common side effects: abdo pain, gi effects etc
• uncommon side effects:
• drug-drug interactions: cns depressant effects with many drugs
• contra-indications: children and little old ladies

Question 3

metoclopramide

Answer 3

• drug class: d2 antagonist - anti emetic
• common indications: GORD, ileus
• mechanism of action: works centrally in ctz and inhibits d2 therefore no vomiting. also works peripherally and increases ach at muscarinic receptors - pro kinetic
• common side effects:galacttorrhoea, dystonia, parkinsonism
• uncommon side effects:
• drug-drug interactions:
• contra-indications: