Nervous System Flashcards
What does a dendrite do?
Carries impulses towards the cell body
What does a cell body do?
Contains the nucleus of the neurone
What does the axon do?
Carries impulses away from the cell body
What does an axon terminal do?
A synapse is found connecting to the dendrites of the next neurone
What are sodium potassium pumps?
-carrier proteins
-they actively transport na+ ions out of neurones and k+ ions in
-they use ATP and work against concentration gradients
What are sodium and potassium channels?
- channel proteins with specific tertiary structures which only allow ions of the right shape, size and charge to pass through
- when open, they allow facilitated diffusion of either na+ ions or k+ ions in or out of the neurone
- na+ ions and k+ ions are water soluble so cannot diffuse directly through the phospholipid bilateral of the neurone membrane expect through the channels when open
What happens during resting potential?
Neuron cell membranes are polarised.
What is resting potential?
The potential difference across the neuron membrane while the neuron is at rest 
What happens during polarisation?
This is about -70mv to -60mv inside the neuron compared to the outside. A neurone is more negative inside and outside because 3Na plus ions are pumped out of the neurone for every 2K plus ions pumped into it. And sodium and potassium channels are closed. So ions cannot get back in or out of the neurone once plant.
What is action potential?
It is the depolarisation of the neurone membranes inside is more positive on the outside 
What happens during depolarisation?
It is about +40mv inside the inside the neuron compared with the outside. And sodium channels open in response to stimulus and Na ions diffusefuse into the neuron down the concentration gradient created by the sodium and potassium pumps. This is the start of a nerve impulse. 
What is an all or nothing response
Stimulus is a set of an action potential, or it doesn’t
Once an action potential started, it is transmitted along neurons with the same value (40mV)
High intensity stimuli produce the same action potential as low intensity stimuli
However, action potentials are generated more frequently as stimulus intensity increases
The brain interprets a high frequency of nerve impulses as a more intense stimulus
What happens after an action potential has been created
Repolarisation
What happens during repolarisation?
Sodium channels close
Potassium, channels open
K+ ions diffuse out of the neuron down a concentration gradient created by the sodium potassium pump
The neuron repolarises inside of the neuron becomes negative compared to the outside once again 
What happens during hyperpolarisation?
Potassium channels are slow to close, so too many K plus ions diffuse out of the neuron and a potential difference over shoot slightly, making a neuron hyperpolarises, meaning it’s more negative inside than resting potential
How do you sodium potassium pump, restore resting potential?
By pumping NA, plus ions back out of the neuron and K plus ions back in 
What happens during the refractory period?
The refractory period is the time it takes for a membrane to recover from repolarisation and hyper polarisation of the neuron membrane. During this period the neuron cell membrane cannot be excited again. 
What is the function of the refractory period?
1) ensures action potentials don’t overlap by delaying time between them
2) limits the frequency of nerve impulse
3) ensures action potential are on directional

When is sodium channels open at the start of a neuron what happens?
NA plus ions diffuse in, and then the neuron depolarises, and then an action potential is set up 
The influx of an A+ ion sets of transmission of a nerve impulses along the neuron, describe how this works
1) increase in NA, plus ion concentration at the point of depolarisation, set up a local current of na+ ions
2) NA plus ions diffuse sideways along the side of the neuron away from the region of higher concentration
3) this causes sodium channels open further down the neuron, setting of another action potential
4) the local current move, some neuron as a wave of depolarisation, followed by a wave of repolarisation. This is the nerve impulse. 
What affect does myelination have on the speed of conduction?
Myelinated neurons conduct faster than nonmyelinated neurons
Mylan is a fatty substance, so ions are not lipid soluble, so cannot pass through it. This provides electrical insulation 
Why do myelinated neurons conduct faster than nonmyelinated neurons
Because in unmyelinated neurons the whole membrane must depolarise
Why does the myelin provide electrical insulation
Because in myelinated neurons depolarisation only occurs at the nodes action potentials leap along the neuron