Nerves Flashcards
What are neurons
The basic functional unit of the nervous system
What are the specialised morphological features of a neuron
Dendrites
Soma
Axon
Synaptic terminal
What are the dendrites for generally
This is the input portion of the neuron where information is received
What is the soma Of a neuron
The cell body containing the nucleus
What is the axon
The output portion of the neuron which sends information to another neuron or target
What do individual axons bundle together to form
Nerves in the PNS and tracts in the CNS
What are nerves ensheathed in
Epineurium
What are arbours
The branching of the dendrites
What does the rate of conduction of a neuron depend on
The diameter of the axon
the degree of myelination
distance between non-myelinated nodes
What creates the myelin sheath
Schwann cells (PNS) and oligodendrocytes (CNS)
In the PNS small diameter on myelinated axons are ensheathed by membranes of what
Non myelinating Schwann cells
What are neuron cell bodies in ganglia surrounded by
Satellite glia
Besides oligodendrocytes, What isthe other major glia cell type
Astrocytes
What do you astrocytes contribute to
The blood brain barrier and remove neurotransmitters from synapses
What line is the central canal of the spinal-cord and the brain ventricles
What do they do
Ependymal cells
Secrete cerebrospinal fluid and assist in its circulation
What do microglia do
What are they
Immune function
Resident phagocytes of the brain and spinal cord which are derived from mono sites i.e. from large white blood cells that are part of the innate immune system
What do you call a ganglion in the CNS
A nucleus
What does a “nerve fibre” refer to
An axon and it’s myelin sheath but can also refer to dendrites
What does the central nervous system developed from
The neural tube which forms from the ectoderm
What do peripheral nervous system neurons mostly develop from
Neural crest cells
What are neurogenic placodes?
What do they give rise to
Bilateral patches of thickened ectoderm
Olfactory epithelium (including all olfactory receptor neurons)
Eye lenses
Inner ear (for hearing and balance)
Some somatosensory neurons
All vestibulocochlear
All taste and viscerosensory afferent neurons
Where are the cell bodies of viscerosensory afferent neurons located
Cranial sensory ganglia associated with some cranial nerves
How do neurons develop from neurogenic placodes
Neurons delaminate from a placode, migrate internally and coalesce with neural crest derived glia to form a ganglion
What are the features of the brain but you have to know for first year
12 pairs of cranial nerves interface between the brain and periphery and viscera, carrying sensory, motor and autonomic information
(Eg from retina to Brain or from brain to muscles)
What are the 3 meninges
From out to in
Dura, arachnoid and pia mater
What are the ventral roots
Bundles of efferent motor axons leaving the ventral regions of the spinal-cord
When does the spinal cord stop growing? What about the vertebral column?
In infancy but the vertebral column keeps growing
Therefore the adult spinal cord ends around L1
Where are lumbar puncture and spinal anaesthesia performed
L4
Which nervous system due to 31 pairs of spinal nerves belong to
Somatic
How many coccygeal spinal nerves are there
1
How do you spinal nerves exit the vertebral column
Through the intervertebral foramina
Name 4 peripheral nerve plexuses
Cervical
Brachial
Lumbar
Sacral
What do thoracic rami nerves form
Intercostal nerves (NOT plexuses)
What is a dermatome
An area of skin that provides sensory input to one pair of spinal nerves or to cranial nerve five
What is a preganglionic neuron and where is it found
Which nervous system has these
A cell body in the central nervous system which conveys information to a postganglionic neuron
ANS
True or false: postganglionic neurons are neural crest derived
True
Give seven broad categories of clinical disorders regarding the nervous system
Developmental problems (spina bifida)
cell proliferation
Traumatic nerve injury
Cerebrovascular dysfunction (stroke)
Sensory dysfunction e.g. various anopias
Motor dysfunction e.g. palsy
The general degenerative diseases e.g. Alzheimer’s
Why is understanding of synaptic transmission important clinically
Target for pharmaceuticals
4 functions of glia
Structural support
Insulation
Immune function
Removal of chemicals
Etymology of dendrite
Dendro = tree
Do gap junctions allow 2 way transmission
Yes
What does central nervous system grey matter consist of
Neuron cell bodies, dendrites, axon terminals, bundles of unmyelinated axons, glia
What covers nerves
A collagenous matrix called epineurium
What are fascicles of axons covered by
Perineurium
What is perineurium
Concentric layers of large flat perineurial cells
these are the barrier to diffusion and infection
What are groups of axon Schwann cells embedded in
A gel like matrix: endoneurium.
What is the visceral nervous system
The ANS
Where are the cell bodies of general visceral afferent neurons
In the inferior ganglia of cranial nerves IX and X
What are cranial nerves
a) IX
b) X
a) petrosal
b) nodose
What do general visceral sensory neurons do
Transmit “interoceptive” information To various nuclei in the nucleus of the solitary tract (NTS)in the medulla
Give an example of interoceptive information
E.g. Baroreceptors about changes in blood pressure
Are signals from general visceral sensory neurons perceived consciously
No but intense stimulation may cause pain or nausea
What regulates the activity of a print/motor neurons in the ANS
Descending projection
Promoter neurons
Preganglionic sympathetic exons tend to be…
Short
What do you preganglionic sympathetic neurons release
Therefore they are
ACh
Cholinergic
Sympathetic postganglionic neurons release what?
What are they therefore ?
Noradrenaline
Adrenergic
Almost all sympathetic post ganglionic neurons release noradrenaline. What is the exception
Postganglionic neurons to sweat glands which release : ACh
Where are parasympathetic ganglia located
What does this mean for the length of the preganglionic and postganglionic axons
They are intramural so are located near or within the wall of the target effector
Pre: long
Post: short
How many postganglionic neurons can a preganglionic sympathetic neuron synapse with
What does this explain
20+ (supplying different effectors)
Why sympathetic effects tend to be widespread in the body
How many postganglionic neurons does a preganglionic parasympathetic neurons synapse with
4-5 (which all supply the same visceral effector)
True or false
parasympathetic effects tend to be widespread
False they are usually localised
Describe the thoracolumbar outflow of the SNS
myelinated preganglionic axons which originate from neuronal bodies in the intermediolateral nucleus of T1 to L2 spinal segments
How do sympathetic preganglionic axons concerned with blood vessels, sweat glands and hair follicles travel
Via the ventral roots and white rami to synapse onto neural crest derived postganglionic neurons in sympathetic chain ganglia at all levels
Where do the sympathetic chains meet
Coccyx
How do postganglionic axons exit the sympathetic chain
Via grey rami to rejoin and travel with spinal nerves to the target effectors
Why are there two pairs of spinal nerves rami at the thoracic spinal levels
That are white and grey rami to/from the sympathetic chain and dorsal and ventral running to the back/trunk and limbs
From which ganglion do postganglionic postganglionic axons travel to eye muscles, lacrimal and salivary glands
What about to the heart and lungs?
Superior cervical ganglion
Middle/inferior cervical and T1–5 ganglia
What is the stellate ganglion
A fusion of the inferior cervical ganglion and the T1 ganglion
How many pairs of sympathetic ganglion are there
~25