Nerve Cells Flashcards
Basic functional unit of CNS
Nerve Cells
Protectors and repairers of nerve cells
Neuroglial cells
Input to neuron
Cell body and dendrite
Output of neuron
Axon
Two components of cell body
Nucleus and Cytoplasm
Cytoplasm organelles funtion?
metabolize protein for maintenance and growth
Protein of cell bodies conducted through:
Microtubles
Mitochondria function
Cellular power plants, Energy in form of ATP
Lysosomes function
Intracellular digestion
Ribosomes function
Assemble protein
Golgi Bodies function
Protein secretion
Branching of dendrites known as:
Arborization
Part of neuron with greatest density of voltage dependent sodium channels
Axon Hillock
Axons termination branches
Telodendria
Intervals between Myelin Sheath
Nodes of Ranvier
Supply myelin for PNS neurons
Schwann Cells
Supply myelin for CNS neurons
Oligodendrocytes
Myelin growth
Myelogenesis
Connection point between neurons
Synapse
Three parts of synapse
Knob, cleft, receptive site
Receptive sites
Axodendritic synapse, axoaxonic synapse, axosomatic synapse
Unipolar neurons
Dendrite and axon emerging from same process
Bipolar neurons
Single axon and single dendrite on opposite ends of soma
Multipolar neurons
More than two dendrites
Golgi I
Neurons with long-projecting axonal processes
Golgi II
Neurons whose axonal process projects locally
Afferent neurons
Convey information from tissues and organs into CNS
Efferent
Transmit signals from CNS to effector cells
Interneurons
connect neurons within specific regions of CNS
Convergent circuit
Receive info from multiple sources
Divergent circuit
Amplifies an impulse
Lateral inhibition
Results in sharpening response by inhibiting adjacent neurons
Reverberating circuits
Self-propagating system
Neuron not transmitting a signal
Resting State
Resting membrane potential
-70 mV
Inside cell molecule concentration
Low in Sodium and high in Potassium
Maintains concentration gradients for both sodium and potassium ions
Sodium-potassium active pump
What changes the shape of the protein ion channel?
Addition of phosphate group to ATP
When phosphate is release and protein returns to former shape what happens?
two potassium ions are moved across membrane
Hyperpolarization
Cell interior becomes more negative
Depolarization
Cell interior becomes less negative
Action potential
Temporary reversal of charges of neuron cell
To trigger action potential how much change in mV?
10 mV, threshold
Excitatory stimulus causes:
voltage-gated sodium channels to open
When do the sodium channels close?
+40 mV
When action potential is reached?
Potassium channels begin to open
Movement of potassium ions causes?
Reversal of membrane potential to negative, Repolarization
Overshooting of electrical gradient called?
Hyperpolarization, -80 to -90 mV
What is the name of the period after hyperpolarization?
Refractory period
How long do action potentials last?
5-10 milliseconds
Why does action potential only travel in one direction?
Membrane behind is still in refractory
Two factors affecting action potentials
Axon diameter and myelination
Voltage gated sodium channels are concentrated in?
The nodes of ranvier
Conduction along myelinated fibers
Saltatory Conduction
Release of neurotransmitters
Exocytosis
Arriving action potential produces influx of?
Calcium ions
Postsynaptic potentials are?
Graded potentials
If pump results in net gain of positive charge across membrane:
Excitatory postsynaptic potential
If pump results in net gain of negative charge?
Inhibitory postsynaptic potential
Excitatory Postsynaptic Potentials neurotransmitter bindings
Flow of Sodium or carbon, membrane becomes less negative
Inhibitory PP
Leads to opening of chlorine or potassium channels, more negative
Action potential will occur in postsynpatic neuron if postsynaptic cell is?
Depolarized
Two types of Neurotransmitters
Small and large molecules (short and long lasting)
Acetylcholine
In CNS, regulates forebrain activity, In PNS, controls voluntary movements of motor fibers
Dopamine
Affects movement and cognition and memory
Dopamine also functions as:
Motivation and pleasure
Norepinephrine
stress hormone, fight-or-flight responds
Serotonin
Plays role in regulation of mood, sleep, emesis, sexuality and appetite
GABA
Brains natural calming agent