Nephritic/nephrotic bx findings

Question 1

LM: segmental sclerosis and hyalinosis
IF: negative
EM: effacement of foot processes

Answer 1

FSGS

Question 2

LM: diffuse capillary and GBM thickening
IF: granular
EM: “spike and dome” appearance with subepithelial deposits

Answer 2

Membranous glomerulonephropathy

Question 3

LM: normal glomeruli
IF: negative
EM: effacement of foot processes

Answer 3

Minimal change disease

Question 4

LM: congo red stain showing apple-green birefringence under polarized light

Answer 4

Amyloidosis

Question 5

LM: “tram tracking” from mesangial ingrowth–> GBM splitting
IF: granular
EM: Subendothelial IC deposits

Answer 5

Type I membranoproliferative glomerulonephritis

Question 6

LM: some degree of tram tracking
IF: granular
EM: intramembranous IC deposits

Answer 6

Dense deposit disease (type II membranoproliferative glomerulonephritis)

Question 7

LM: mesangial expansion; GBM thickening; eosinophilic nodular glomerulosclerosis

Answer 7

Diabetic glomerulonephropathy

Question 8

LM: enlarged, hypercellular glomeruli
IF: granular (lumpy-bumpy)
EM: subepithelial IC humps

Answer 8

Acute PSGN

Question 9

LM: crescent moons
IF: crescent moons

Answer 9

Rapidly progressive GN

Question 10

LM: Wire looping
IF: granular
EM: subendothelial (+/- intramembranous) IgG-based ICs

Answer 10

DPGN

Question 11

LM: mesangial proliferation
IF: IgA-based IC deposits in mesangium
EM: mesangial IC deposits

Answer 11

IgA nephropathy

Question 12

LM: basket weave pattern of GBM

Answer 12

Alport syndrome