Neoplastic Diseases Flashcards
What is a neoplasm? What kind of growth is it?
- Tumor, lesion
- Abnormal tissue growth
What can we describe a neoplasm on ultrasound? 2
- Diffuse or focal
- Distinct mass or ill- defined
Are neoplasms benign or malignant?
Both
What are two types of malignant neoplasms?
- Primary
- Metastases
Benign neoplasms are typically asymptomatic or symptomatic?
Asymptomatic
Will there be any types of test for benign neoplasms?
No altered lab tests
What are some features of benign neoplasms? 5
- Slow growing
- Encapsulated
- Well defined
- Hypovascular to avascular
- DO NOT METASTASIZE
What is the most common type of liver tumor?
Hemangiomas
What are the chances of occurrence for hemangiomas for both women and men?
Women > Men (5:1)
Are hemangiomas asymptomatic or symptomatic?
Asymptomatic
When do hemangiomas increase for women?
During pregnancy or estrogen therapy
What are the typical size of hemangiomas? And what are some sonographic descriptors? 3
- Typically small (<3cm)
- Well defined
- Homogenous and hyperechoic
Hemangiomas might include a ________________ _________ ________ with hypoechoic components
Heterogenous central area
What is the flow seen with hemangiomas?
Slow flow not typically detected by doppler
What is the following up time if someone has a hemangiomas?
6 month follow up, document to change
What are focal nodular hyperplasia (FNH)?
Hyperplasticity lesion containing all elements of normal liver tissue
What is the occurrence rate of focal nodular hyperplasia between men and women? Why?
- Women > men
- Influenced by hormones
What is FNH known as?
Stealth lesion
Are focal Nodular hyperplasia asymptomatic or symptomatic?
Asymptomatic
What is the sonographic appearance of FNH? 2
- Central area of decreased echogenicity (central scar)
- Subtle (look for a contour abnormalities/ displaced vessels)
How big are focal nodular hyperplasia (FNH)?
Less than 8 cm
What are the doppler flow of focal nodular hyperplasia?
Central
When a sulphur colloid is done what might FNH might show?
Hot or warm
How common are liver Adenomas?
Less common than FNH
What drugs are liver adenomas linked to?
Oral contraceptives
What other disease are liver adenomas related to?
Type 1 glycogen storage disease (GSD, von gierke’s disease)
Are adenomas asymptomatic or symptomatic?
Asymptomatic
Can liver adenomas hemorrhage?
Yes they can also infarct which leads to pain
What is the sonographic appearance of liver adenomas? 3
- Nonspecific (hyperechoic but variable)
- Solid, solitary, and well encapsulated
- Doppler shows central area of colour
How big are adenomas typically?
8-15 cm
What does adenomas show on sulphur colloid scans?
Cold
How common are lipomas?
Very rare
Lipomas are normally asymptomatic or symptomatic?
Asymptomatic
Lipomas sonographic appearance is what? 2
- Hyperechoic
- Very similar to hemangioma
What does CT or MRI do for Lipomas?
Contrast enhanced
What are some things we can do to correlate information? 5
- Contrast enhanced CT or MRI
- RBC scintigraphy
- Sulfer colloid scans
- Micro bubble enhanced sonography
- Biopsy
What is the treatment options for hemangiomas?
Repeat ultrasound after 3-6 months
What is the treatment options for FNH?
Conservative, depending on size
What is the treatment options for adenoma?
Surgery recommended
What is the treatment options for lipomas?
Conservative
What is the sonographic appearance of the spleen? 5
- Extremely homogenous
- More echogenic than the kidney
- Isoechoic or slightly more echogenic to the liver
- Hilum disrupted by vessels
- Inverted comma shape
What kind of disease is a cavernous hemangiomas?
Congenital
What is the most common benign neoplasm of spleen?
Cavernous hemangioma.
seen far less frequently in the spleen that the liver
Are cavernous hemangiomas symptomatic or asymptomatic?
Asymptomatic
What is the sonographic appearance of cavernous hemangiomas?
Variable: hyperechoic to complex with cystic degeneration
How conclusive are ultrasounds for cavernous hemangiomas?
They are not conclusive, further testing required to differentiate.
How common are hamartoma?
Rare
What does Hamartoma’s affect?
Lymphoid tissue
What is the sonographic appearance of Hamartoma’s? 4
- Homogenous
- Solid
- Echogenic
- Not encapsulated
How common are lymphangioma?
Rare
What are lymphangiomas?
Lymphatic malformation
What is the sonographic appearance of lymphangiomas? 2
- Variable appearance
- Cystic lymph-angiomyomatosis, multi Lobulated cystic mass
What is an example of true neoplasm?
Adenomas
Adenomas are symptomatic or asymptomatic?
Asymptomatic
How big are GB adenomas?
Less than 10 mm
What is the GB adenomas sonographic appearance? 3
- Hyperechoic
- Homogenous
- Hypovascular
What is cholesterolosis?
Accumulation of cholesterol in the gallbladder wall
What are different types of cholesterolosis? 2
- Cholesterosis
- Cholesterol polyps
What is cholesterosis also called?
Strawberry gallbladder
How will cholesterolosis (strawberry gallbladders) look like?
Multiple non- shadowing masses fixed to the GB wall
What kind of form does cholesterol polyps have? Can Cholesterol polyps and adenomas be differentiated with U/S? 2
- Focal form
- Polyps and adenomas cannot be differentiated with U/S
Adenomyomatosis is a exaggeration of what?
RA sinuses
Adenomyomatosis is what? (Proliferation of what?)
Smooth muscle proliferation
What is the Adenomyomatosis sonographic appearance? 3
- Focal or diffuse
- Hyperehoic focus in wall
- Comet tail artifact
Adenomyomatosis are most commonly found where in the GB?
GB fundus
Adenomyomatosis less commonly affects what?
The mid portion creating an hourglass GB
What is a Adenomyomas?
Mass like focal area of adenomyomatosis
Adenomas in the gallbladder are commonly referred to as what?
Polyps
What is the sonographic appearance of the pancreas? 4 (comparison to the liver, duct location, echo texture)
- Homogenous
- Slightly coarser than liver
- ISO/ slightly hypo to liver
- Duct may be visible at panc body
Islet cell tumours are benign or malignant ?
Both
Islet cell tumors function and non function at what degrees?
Functioning (85%) or non- functioning (15%)
What is the most common type of islet cell tumor?
Insulinoma
Insulinomas are benign or malignant?
Benign
What does the islet cell tumors affect? (which part of the organ?)
Typically the body or tail of the pancreas
What is the sonographic appearance of islet cell tumors? 4
- Well encapsulated
- Solitary
- Frequently hypoechoic, though larger tumors may be moderately echogenic
- variable size
What is the significance of the two images?
Benign neoplasms of the kidneys
What does angiomyolipomas affect? 2
- Cortex of the kidneys
- Fat, muscle, blood vessels
What demographics does angiomyolipoma’s affect?
Middle age females
What are some sonographic characteristics of angiomyolipoma’s? 4
- Hyperechoic, defined
- Typically unilateral
- Low blood flow
- Bilateral, multiple
Is angiomyolipoma’s asymptomatic or symptomatic?
Asymptomatic
What can angiomyolipoma’s mimic?
Renal cell carcinomas
What is angiomyolipoma’s associated with?
Tuberous sclerosis
What does this image demonstrate?
Angiomyolipoma
How does the kidney adenoma compare in size to the oncocytoma?
- Adenoma <3cm
- Oncocytoma >3cm
Kidney Adenoma/ oncocytomas are typically asymptomatic or symptomatic? What is another s/s seen with this?
Asymptomatic with possible hematuria, pain
Which demographic does kidney adenoma/ Oncocytoma affect?
- Male >female
- 6th and 7th decade
What does kidney adenoma/ Oncocytomas mimic?
Renal cell Cancer
What is the sonographic descriptors of kidney adenoma/ Oncocytoma? 2
- Well defined
- Hypoechoic or isoechoic
What does this image demonstarte?
Adenoma/ oncocytoma
Where does adrenal adenomas form?
Adrenal cortex
Adrenal Adenomas are hyperfunctioning or nonfunctioning?
Both but nonfunctioning most likely
What are some characteristics of adrenal adenomas? 2 (quantity)
- Commonly unilateral
- May be multiple
Hyperfunctioning adrenal adenomas can result in what?2
Endocrine abnormalities such as
1. Cushing’s syndrome
2. Conn’s disease
What does this image demonstrate?
Adrenal Adenoma
How common are myelolipomas?
Rare
Myelolipomas may arise from what? (Adrenal)
Zona Fasciculata
Are myelolipomas non-functioning or functioning?
Non functioning
Which demographics does myelolipomas affect?
- Male = females
- 5 to 6 decade
What are some sonographic descriptors of myelolipomas? 4
- Hyperechoic
- Most <5cm
- Blend into perirenal fat
- Propagation speed artifact
Pheochromocytomas are what kindof tumour? (Hyper functioning or non functioning, what organ does it affect)
Hyperfunctioning tumor of the medulla
What are some signs and symptoms of pheochromocytomas? 5
- Hypertension
- Palpitations
- Tachycardia
- Excessive sweating
- Urinary catecholamines elevated
Which demographics are affected by Pheochromocytomas? (Age and side)
- 4th to 5th decade
- Rt > Lt
What disorders is pheochromocytomas associated with? 2
Tuberous sclerosis and MEN syndrome
What are some sonographic descriptors of pheochromocytomas? 7
- Solid
- Unilateral
- Encapsulated
- Hypoechoic
- Homogenous
- Heterogenous
- > 2cm
What is demonstrated in this image?
Pheochromocytoma?
What does desmoid tumors arise from? Where does it usually affect?
- Connective tissue
- Usually anterior wall (@ surgical or laparoscopic site)
What are event desmoid tumors associated with?
Postpartum
How does desmoid tumors grow?
Slow growing but infiltrative locally
Which demographic of individuals are affected by desmoid tumors?
- females > males
- 20 to 40 years of age
What does the desmoid tumor look like sonographically?
Hypoechoic, homegenous
What are lipomas consisting of?
fat
What are some characteristics of lipomas?4
- Mobile
- Soft on palpation
- Compression
- Echogenic»_space;» highly echogenic
What does this image demonstrate?
Lipomas
Malignant tissue orginates from various types of tissue, what, are some ? 2
- Primary
- Secondary (metastatic)