Neoplasms Flashcards

1
Q

Risk factors for breast cancer

A

Nulliparity
Early menarche
Late menopause
Postmenopausal combo HRT

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2
Q

S/S of breast cancer

A

Painless breast mass
Fixed
Hard
Irregular margins

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3
Q

MC location of breast cancer

A

Upper outer quadrant

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4
Q

S/S of Paget’s disease of the breast

A

Itching, pain, and burning of breast
Superficial erosion or ulceration
Bloody nipple discharge

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5
Q

Diagnosis of Paget’s disease of the breast

A

Full-thickness biopsy

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6
Q

Treatment of Paget’s disease of the breast

A

Mastectomy

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7
Q

S/S of inflammatory carcinoma

A

Orange peel sign (peau d’orange)
Brawny edema

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8
Q

Treatment of inflammatory breast cancer

A

Multiple chemo rounds
Followed by radiation and surgery

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9
Q

Screening for breast cancer

A

Mammogram annually after 40

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10
Q

Diagnosis of breast cancer

A

Core needle biopsy

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11
Q

Which has better outcomes, ER- or +?

A

+

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12
Q

If ER+ ___

A

Raloxifene or Anastrozole

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13
Q

Worst type of breast cancer

A

Triple negative

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14
Q

CIN types

A

CIN 1: mild, lower 1/3
CIN 2: moderate, lower 2/3
CIN 3: severe, over 2/3

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15
Q

Gardasil vaccine

A

Recommended at age 11-12 (from Hannah’s quizlet)

Age 9-14: 2-dose - 0 months and 6-12 months OR 3-dose - 0, 2, 6 months
Age 15-45: 3-dose (0, 2, 6 months)
(from Epperly’s slides)

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16
Q

Cervical cancer screening

A

Start at age 21
Pap every 3 years until 30
Pap & HPV every 5 years from 30-65 OR pap only every 3 years

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17
Q

When to stop screening for cervical cancer?

A

65+
No hx of moderate or severe dysplasia
3 negative paps in a row

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18
Q

Pap smear results

A

ASCUS (undetermined significance)
ASCH (cannot exclude high-grade lesion)
LGSIL (low-grade squamous intraepithelial, corresponds to CIN 1)
HGSIL (high-grade squamous intraepithelial, corresponds to CIN 2/3)
AGC (atypical glandular cells)

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19
Q

Treatment of ASCUS

A

Repeat paps every 6 months until normal

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20
Q

Next step for LGSIL and HGSIL

A

Colposcopy and biopsy

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21
Q

Treatment of CIN 1

A

Expectant management
2 paps every 6 months or pap & HPV test every 6 months

22
Q

Treatment of CIN 2 or 3

A

Surgical procedure

23
Q

HPV strains most correlated with cervical cancer

A

16, 18, 45

24
Q

S/S of cervical cancer

A

Abnormal vaginal bleeding
*Postcoital bleeding

25
Q

Treatment of cervical cancer

A

Radical hysterectomy and lymphadenectomy

26
Q

Most common gyn malignancy

A

Endometrial cancer

27
Q

Risk factors for endometrial cancer

A

Unopposed estrogen
Obesity

28
Q

Risk reduction for endometrial cancer

A

Combo OCP use
Smoking

29
Q

S/S of endometrial cancer

A

Abnormal uterine bleeding

30
Q

MCC of endometrial cancer

A

Adenocarcinoma

31
Q

Diagnosis of endometrial cancer

A

US first
Biopsy

32
Q

Treatment of endometrial cancer

A

Total hysterectomy with bilateral salpingo-oopherectomy

33
Q

MCC of ovarian cancer

A

Epithelial ovarian cancer

34
Q

Risk factors for ovarian cancer

A

Smoking
Early menarche
Late menopause
Nulligravid

35
Q

Risk reduction of ovarian cancer

A

OCP
Breast feeding

36
Q

S/S of ovarian cancer

A

Vague symptoms
Solid, fixed, irregular adnexal mass

37
Q

Labs for ovarian cancer

A

CA-125

38
Q

Diagnosis of ovarian cancer

A

US first
Biopsy

39
Q

Treatment of epithelial ovarian cancer

A

Surgical removal
Chemo

40
Q

Treatment of germ cell cancer

A

Surgery alone

41
Q

S/S of extramammary Paget’s disease

A

Pruritus
Vulvar soreness
“Red velvet cake” appearance

42
Q

Diagnosis of extramammary Paget’s disease

A

Biopsy

43
Q

Treatment of extramammary Paget’s disease

A

Wide local excision

44
Q

MCC of vulvar cancer

A

SCC

45
Q

S/S of vulvar cancer

A

Pruritus or mass of vulva

46
Q

Treatment of vulvar cancer

A

Wide radical excision with inguinal lymph node excision

47
Q

MCC of vaginal cancer

A

SCC

48
Q

S/S of vaginal cancer

A

Grape-like mass
Bleeding

49
Q

Diagnosis of vaginal cancer

A

Biopsy

50
Q

Treatment of vaginal cancer

A

Hysterectomy
Vaginectomy
Lymphadenectomy