Neoplasia I

Question 1

What pathological process does Neoplasia fall under?

Answer 1

Disorder of growth

Question 2

Is neoplasia uncontrolled or controlled growth?

Answer 2

Uncontrolled

Question 3

What are three types of lesions that usually produce tumors? (think NAG)

Answer 3

Neoplasm
Abscess
Granuloma

Question 4

What is a tumor?

Answer 4

A “swelling”

Question 5

What is another name for cancer?

Answer 5

“Crab”

Question 6

What two main things does neoplasm consist of?

Answer 6

1. Neoplastic cells (parenchyma)

2. CT and blood vessels (“stroma”)

Question 7

A stroma is what type of tissue?

Answer 7

Vascular fibrous CT

Question 8

What two things can parenchymal cells be?

Answer 8

1. Epithelial cells

2. Mesenchymal cells

Question 9

Where are epithelial cells found?

Answer 9

Most organs, epidermis, mucosa, glands

Question 10

What germ cell layer are epithelial cells derived from?

Answer 10

Any germ cell layer (endo-, ecto-, and mesoderm)

Question 11

Where are mesenchymal cells normally found?

Answer 11

CT, muscle, endothelial cells, bone marrow & blood

Question 12

What are mesenchymal cells derived from?

Answer 12

Mesoderm

Question 13

Round to spindle shaped cells with scant cytoplasm describe epithelial or mesenchymal cells?

Answer 13

Mesenchymal cells

Question 14

What three things are needed for make an MDx for a neoplasm?

Answer 14

1. Location
2. Prefix for tissue of origin
3. Suffix for growth behavior

Question 15

If a neoplasm is epithelial and benign, what suffix is given form growth behavior?

Answer 15

-Oma

Question 16

If a neoplasm is mesenchymal and benign, what suffix is given form growth behavior?

Answer 16

-oma

Question 17

If a neoplasm is epithelial and malignant, what suffix is given form growth behavior?

Answer 17

-carcinoma

Question 18

If a neoplasm is mesenchymal and malignant, what suffix is given form growth behavior?

Answer 18

-Sarcoma

Question 19

What is the prefix for tumors derived from fibrous CT?

Answer 19

Fribro-

Question 20

Is is the prefix of a tumor derived from vascular endothelium?

Answer 20

Hemangio-

Question 21

What is the prefix for a tumor derived from glandular epithelial cells?

Answer 21

Adeno-

Question 22

What is the prefix for a tumor derived from bone?

Answer 22

Osteo-

Question 23

What is the prefix for a tumor cell derived from lymphocytes?

Answer 23

Lympho-

Question 24

What prefix is given to a tumor derived from more than one cell lineage?

Answer 24

Terato-

Question 25

A well-differentiated area will be more likely what type of neoplasm?

Answer 25

Benign

Question 26

The less differentiated an area, the more malignant or benign a tumor?

Answer 26

Malignant

Question 27

Features of anaplasia (cellular atypia) are observed in what type of neoplasm?

Answer 27

Malignant

Question 28

List some features of anaplasia

Answer 28

1. pleomorphic 2. Anisokaryosis/anisocytosis 3. Nuclear hyperchromasia 4. High N:C ratio 5. Prominent nucleoli 6. Multiple nucleoli 7. Abnormal mitotic figures

Question 29

What are the differentiations of a benign tumor?

Answer 29

Well-differentiated Structure similar to tissue of origin Little or no anaplasia

Question 30

What are the differentiations of a malignant tumor?

Answer 30

Lack differentiation Structure atypical Variable anaplasia

Question 31

What are the growth rate features of a benign tumor?

Answer 31

Slow, progressive expansion Rare mitotic figures Normal-appearing mitotic figures

Question 32

What are the growth rate features of a malignant tumor?

Answer 32

Slow-to-Rapid Erratic growth rate Numerous mitotic figures/ sometimes abnormal

Question 33

What is the level of invasiveness for a benign tumor?

Answer 33

No invasion (cohesive and expansive growth)

Question 34

What is the level of invasion of a malignant tumor?

Answer 34

Local invasion (infiltrative growth)

Question 35

Does a benign tumor usually have a capsule?

Answer 35

Yes

Question 36

Does a malignant tumor usually have a capsule?

Answer 36

Usually no

Question 37

What is the metastasis of benign tumor growth?

Answer 37

No metastasis

Question 38

What is the metastasis of malignant tumor growth?

Answer 38

Frequent metastasis

Question 39

Who will usually be responsible for differentiation?

Answer 39

Pathologist

Question 40

Who will normally be responsible for determine growth rate?

Answer 40

Clinician and pathologist

Question 41

Who will normally be responsible for determination of local invasiveness?

Answer 41

Clinician and pathologist

Question 42

Who will normally be responsible for determination of metastasis?

Answer 42

Clinician