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Pathology Exam 2 > Neoplasia I > Flashcards

Neoplasia I Flashcards

1
Q

What pathological process does Neoplasia fall under?

A

Disorder of growth

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2
Q

Is neoplasia uncontrolled or controlled growth?

A

Uncontrolled

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3
Q

What are three types of lesions that usually produce tumors? (think NAG)

A

Neoplasm
Abscess
Granuloma

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4
Q

What is a tumor?

A

A “swelling”

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5
Q

What is another name for cancer?

A

“Crab”

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6
Q

What two main things does neoplasm consist of?

A
  1. Neoplastic cells (parenchyma)

2. CT and blood vessels (“stroma”)

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7
Q

A stroma is what type of tissue?

A

Vascular fibrous CT

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8
Q

What two things can parenchymal cells be?

A
  1. Epithelial cells

2. Mesenchymal cells

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9
Q

Where are epithelial cells found?

A

Most organs, epidermis, mucosa, glands

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10
Q

What germ cell layer are epithelial cells derived from?

A

Any germ cell layer (endo-, ecto-, and mesoderm)

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11
Q

Where are mesenchymal cells normally found?

A

CT, muscle, endothelial cells, bone marrow & blood

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12
Q

What are mesenchymal cells derived from?

A

Mesoderm

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13
Q

Round to spindle shaped cells with scant cytoplasm describe epithelial or mesenchymal cells?

A

Mesenchymal cells

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14
Q

What three things are needed for make an MDx for a neoplasm?

A
  1. Location
  2. Prefix for tissue of origin
  3. Suffix for growth behavior
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15
Q

If a neoplasm is epithelial and benign, what suffix is given form growth behavior?

A

-Oma

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16
Q

If a neoplasm is mesenchymal and benign, what suffix is given form growth behavior?

A

-oma

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17
Q

If a neoplasm is epithelial and malignant, what suffix is given form growth behavior?

A

-carcinoma

18
Q

If a neoplasm is mesenchymal and malignant, what suffix is given form growth behavior?

A

-Sarcoma

19
Q

What is the prefix for tumors derived from fibrous CT?

A

Fribro-

20
Q

Is is the prefix of a tumor derived from vascular endothelium?

A

Hemangio-

21
Q

What is the prefix for a tumor derived from glandular epithelial cells?

A

Adeno-

22
Q

What is the prefix for a tumor derived from bone?

A

Osteo-

23
Q

What is the prefix for a tumor cell derived from lymphocytes?

A

Lympho-

24
Q

What prefix is given to a tumor derived from more than one cell lineage?

A

Terato-

25
Q

A well-differentiated area will be more likely what type of neoplasm?

A

Benign

26
Q

The less differentiated an area, the more malignant or benign a tumor?

A

Malignant

27
Q

Features of anaplasia (cellular atypia) are observed in what type of neoplasm?

A

Malignant

28
Q

List some features of anaplasia

A
  1. pleomorphic
  2. Anisokaryosis/anisocytosis
  3. Nuclear hyperchromasia
  4. High N:C ratio
  5. Prominent nucleoli
  6. Multiple nucleoli
  7. Abnormal mitotic figures
29
Q

What are the differentiations of a benign tumor?

A

Well-differentiated
Structure similar to tissue of origin
Little or no anaplasia

30
Q

What are the differentiations of a malignant tumor?

A

Lack differentiation
Structure atypical
Variable anaplasia

31
Q

What are the growth rate features of a benign tumor?

A

Slow, progressive expansion
Rare mitotic figures
Normal-appearing mitotic figures

32
Q

What are the growth rate features of a malignant tumor?

A

Slow-to-Rapid
Erratic growth rate
Numerous mitotic figures/ sometimes abnormal

33
Q

What is the level of invasiveness for a benign tumor?

A

No invasion (cohesive and expansive growth)

34
Q

What is the level of invasion of a malignant tumor?

A

Local invasion (infiltrative growth)

35
Q

Does a benign tumor usually have a capsule?

A

Yes

36
Q

Does a malignant tumor usually have a capsule?

A

Usually no

37
Q

What is the metastasis of benign tumor growth?

A

No metastasis

38
Q

What is the metastasis of malignant tumor growth?

A

Frequent metastasis

39
Q

Who will usually be responsible for differentiation?

A

Pathologist

40
Q

Who will normally be responsible for determine growth rate?

A

Clinician and pathologist

41
Q

Who will normally be responsible for determination of local invasiveness?

A

Clinician and pathologist

42
Q

Who will normally be responsible for determination of metastasis?

A

Clinician

Pathology Exam 2 (5 decks)

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