Healing & Repair Flashcards
What are necrotic cells replaced with during repair?
Vital cells
What are two types of repair?
- Parenchyma regeneration
2. Fibrosis
T/F: Parenchymal regeneration sometimes leaves no residual trace of injury
True
What two components are needed for parenchymal regeneration to happen?
- Regeneration capacity
2. Maintains CT framework
T/F: Fibrosis results in a decrease in collagen w/in tissues
False; increase
What the three types of cells based on regenerative capacity?
- Labile cells
- Stable cells
- Non-dividing/permanent cells
What are some consequences of fibrosis?
- Loss of functional parenchymal tissues
2. Alteration of physical properties of tissue
What is the hallmark of healing?
Granulation tissue
T/F: Proud flesh is due to exuberant granulation tissue
True
What are the 4 zones of granulation tissue?
- Zone of necrotic debris and fibrin
- Zone of macrophages
- Zone of proliferation capillaries and fibroblasts
- Zone of mature fibrous CT
T/F: Healing by first intention is when there is little exudate and tissues are close, while healing by second intention is when wound edges are widely separated
True
What are the 9 general steps of skin healing?
- Blood clot
- Epithelial continuity restored
- Gradual covering
- Inflammation reaction develops
- Neovascularization
- Fibroblast proliferation
- Devascularization
- Egress of inflammatory cells and fibroblast regression
- Scar
Massive hepatic necrosis is an example of healing for which specific tissue?
Liver
Which organ has limited regenerative capacity?
Kindney
What kind of appearance histologically does kidney repaired by regeneration have?
Flattened/ squamoid appearance