Acute Inflammation I, II, & III Flashcards
What are the 5 signs of inflammation?
- Redness
- Heat
- Swelling
- Pain
- Loss of function
What are the roles of inflammation?
- Dilute, contain and isolate injury
- Destroy invading microorganisms and/or activate toxins
- Achieve healing and repair
What are the 3 different outcomes of inflammation?
- Return to normal
- Intense inflammatory response
- Failure to eliminate
What is formed during an intense inflammatory response?
Capsule of fibrous CT
What will happen in failure to eliminate insult?
- Persistence of inflammatory cells
2. Scar formation
T/F: inflammation can occur in dead tissue
False, only in living tissue
Inflammation leads to the accumulation of fluid and WBCs in what type of tissue?
Extravascular tissues
What process is inflammation closely associated with?
Repair
What is exudation?
Escape of fluid, proteins, and blood cells from vascular system into interstium or body cavities
What are 3 properties of exudate?
- High protein concentration
- Cellular debris
- High specific gravity
What are two features of transudate?
- Low protein content
2. Low specific gravity
What is pus?
Inflammatory exudate rich in leukocytes and parenchyma cell debris
What are 7 types of exudate?
- Serous
- Fibrinous
- Suppurative
- Granulomatous
- Serofibrinous
- Firbrino-purulent
- Purulent
What are the main characteristics of peracute inflammation?
- Cause by potent stimulus
- Usually no time to respond
- Less common then acute
What are some general features of peracute inflammation?
- Short time
- Vascular involvement
- Inflammatory cells
- Shock, sudden death
Infectious canine hepatitis is a main example of what type of inflammation?
Peracute inflammation
What type of cells are predominant in acute inflammation?
Neutrophils
Lymphadenitis occurs in what type of inflammation?
Acute, subacute, and chronic
What is lymphangitis?
Inflammation of lymphatic vessels
T/F: Fibrosis and neovascularization are features of subacute inflammation
False, they are not features
Fibrosis is usually an indication of what time of inflammation?
Chronic
What types of cells are seen in chronic inflammation?
Mononuclear inflammatory cells
Suppurative education consists of what type of liquid inflammation product?
Pus (purulent)
Pyometra is an example of what type of inflammation?
Severe suppurative inflammation
What is the process by which pus is formed?
Suppuration
What is an abscess?
Collection of pus (localized)
What is the main content of fibrinous exudation?
Fibrin
Fibrinous cholecystitis is an example of what type of inflammation?
Fibrinous inflammation
What is fibrinopurulent exudate?
Fibrin and pus together
What is the difference between fibrinous exudate and fibrosis?
Fibrinous exudate is an acute process and fibrosis is a chronic process
In the absence of prominent cellular response, what type of exudation occurs?
Serous exudation
In serous exudate, what happens after a vesicles rupture?
Ulceration
T/F: Granulomatous inflammation is always chronic
True
What is the predominant cell in granulomatous inflammation?
Macrophages
What two types of cells are present in granulomas?
Epithelioid and multinucleated giant cells
What type of appearance would a granulomatous inflammation have?
Cerebroid
What is the main feature of necrotizing inflammation?
Necrosis
What is the main feature of hemorrhagic inflammation?
Hemorrhage
What is mucopurulent or catarrhal?
Mucus and pus exudate
T/F: A MDX is not complete until an anatomical location has been added
true
What are two subdivision of inflammatory cells?
- Polymorphonuclear leukocytes
2. Mononuclear cells
What is the purpose of neutrophils?
Eliminate microorganisms, tumor cells, and foreign material
What are two major classes of granules in neutrophils?
- Azurophil granules (primary)
2. Specific granules (secondary)
What are some important neutrophil functions?
- Phagocytosis
- Medicate tissue injury
- Regulate inflammatory response
T/F: Eosinophils have cytoplasmic eosinophilia granules
True
Eosinophils are effective at killing what type of parasites?
Helminths
What are some examples of eosinophilic infiltration?
- Contact dermatitis
- Habronema infection
- Prominent mast cell tumors
What are the key mediators of lymphocytes and plasma cells?
Immediate Ab response and delayed cellular hypersensitive response
What cell is a chronic inflammatory cell?
Macrophages
The effects of inflammatory stimuli are manifested through what mediators?
Chemical mediators
Chemotaxis is the emigration of what type of cells?
WBCs