Neoplasia & Cancer Flashcards
what are the three hallmarks of acute inflammation with regards to innate immunity?
increased blood flow (vessel dilation)
increased vascular permeability
emigration of neutrophils into tissues
phagocytes are elements of innate immune system what are the two types?
macrophages (arrive first)
neutrophils (which are called my macrophages)
_____ are the guardians of innate immunity
macrophages
what are the phagocytes in innate immunity?
macrophages and neutrophils
macrophages can recognize _____ which is present with tissue damage
DAMPs
what kind of receptors do macrophages use to recognize PAMPs?
toll-like receptors
what are inflammasomes used for?
recognizing cell damage to then produce IL-1 which triggers release of other inflammatory mediators
neutrophils are derived from ____ then circulate in the blood stream
bone marrow
neutrophils provide extra support to ______
macrophages
they can go into tissues and perform phagocytosis
in acute inflammation _____ dominate early (<2 days)
neutrophils
in acute inflammation ____ dominate later and live longer
monocytes/macrophages
in the ______, macrophages are in monocyte form
blood
in _____, monocytes change to macrophages
tissue
the tissue going through acute inflammation will have many multi-lobed nuclei cells = _______
neutrophils
the tissue with chronic inflammation will have cells that are mononuclear with a single, round nucleus = ______
monocytes/macrophage
