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MTC 3 > Cytokines > Flashcards

Cytokines Flashcards

1
Q

which cytokines are secreted by macrophages?

A

IL-1, IL-6, IL-8, IL-12, TNF-alpha

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2
Q

which cytokines are secreted by T cells?

A

IL-2 and IL-3

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3
Q

which cytokines are secreted by Th1 cells?

A

IFN-gamma and IL-2

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4
Q

which cytokine inhibits differentiation of Th2?

A

IFN-gamma

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5
Q

which cytokines does Th2 secrete?

A

IL-4, IL-5, IL-10 and IL-13

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6
Q

what does IL-1 do?

A

causes fever and acute inflammation
activates endothelium to express adhesion molecules
chemokine secretion to recruit WBCs

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7
Q

what are the acute cytokines?

A

IL-1, IL-6 and TNF-alpha

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8
Q

what does IL-6 do?

A

causes fever and stimulates production of acute-phase proteins

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9
Q

what does TNF-alpha do?

A

activates endothelium
causes WBC recruitment and vascular leak

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10
Q

which cytokine maintains granulomas in TB?

A

TNF-alpha

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11
Q

what does IL-8 do?

A

chemotactic factor for neutrophils
“clean up on aisle 8!”

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12
Q

what does IL-12 do?

A

induces differentiation of T cells into Th1 cells
and activates NK cells

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13
Q

which cytokine facilitates granuloma formation in TB?

A

IL-12

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14
Q

what does IL-3 do?

A

stimulates bone marrow

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15
Q

what cytokines activate NK cells?

A

IL-2 and IL-12

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16
Q

what does IL-4 do?

A

stimulates IgE production

“2 BEG 4 help”
differentiation of T cells into TH2 helper cells
growth of B cells
class switching to IgE and IgG

17
Q

what does IL-5 do?

A

stimulates IgA production
“I have 5 BAEs”
growth of B cells
class switching to IgA
stimulates growth of eosinophils

18
Q

what does IL-10 do?

A

attenuates inflammatory response
decreases expression of MHC class II and Th1 cytokines
inhibits activated macrophages and dendritic cells

19
Q

which cytokines attenuate immune response?

A

IL-10 and TGF-beta

20
Q

what does IL-13 do?

A

promotes IgE production by B cells and induces alternative macrophage activation
“thirtEEn”

21
Q

what does IL-2 do?

A

stimulates T cells
and NK cells

MTC 3 (6 decks)

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