Neoplasia - 6 Flashcards by syed ahmed

Keratin

a. Normal tissue expression
b. Tumor

a. All epithelial cells

b. Carcinomas

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Vimentin

a. Normal tissue expression
b. Tumor

a. Mesenchymal cells

b. Sarcomas

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Desmin

a. Normal tissue expression
b. Tumor

a. Muscle cells

b. Uterine leiomyoma, rhabdomyosarcoma

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Neurofilament

a. Normal tissue expression
b. Tumor

a. CNS and PNS neurons; neural crest derivatives

b. Pheochromocytoma, Neuroblastoma

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Glial fibrillary acid protein (GFAP)

a. Normal tissue expression
b. Tumor

a. Glial cells

b. Astrocytoma, ependymomas

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Tartarate resistant acid phosphatase (TRAP)

a. Normal tissue expression
b. Tumor

a. TRAP

b. Hairy cell leukemia

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Chromogranin and synaptophysin

a. Normal tissue expression
b. Tumor

a. Neuroendocrine cells

b. Small cell carcinoma of the lung, carcinoid tumor

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CA - 125 associated with what tumor?

ovarian cancer

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CA-19-9 associated with what tumor?

colon and pancreatic cancer

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CA-15-3 associated with what tumor?

breast cancer

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TP53, APC, RAS mutants in stool and serum are associated with what tumor?

colon cancer

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TP53, RAS mutants in stool and serum are associated with what tumor?

pancreatic cancer

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TP53, RAS mutants in sputum and serum are associated with what tumor?

lung cancer

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TP53 mutants in urine are associated with what tumor?

bladder cancer

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Human chorionic gonadotropin (HCG) is associated with what tumor?

Trophoblastic tumor

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Calcitonin is associated with what tumor?

Medullary carcinoma of the thyroid

Catecholamine and metabolites are associated with what tumor?

Pheochromocytoma and related tumors

Prostatic acid phosphatase is associated with what tumor?

Prostate cancer

Neuron specific enolase is associated with what tumor?

Small cell cancer of the lung, neuroblastoma

Immunoglobulins are associated with what tumor?

multiple myeloma and other gammopathies

Carcinoembryonic antigen is associated with what tumor?

Carcinomas of the colon, pancreas, lung stomach and heart

alpha-fetoprotein is associated with what tumor?

Liver cell cancer

Increased Alkaline phosphatase levels indicates what?

Metastases to bone or liver, Paget disease of bone, seminoma (placental ALP). Exclude hepatic origin by checking LFTs and
GGT levels.

LDH is associated with what tumor?

Testicular germ cell tumors, ovarian dysgerminoma, other cancers; Can be used as an indicator of tumor burden

a. Pap smear is widely used to screen for what? b. What does it allow for us to differentiate between? c. It allows to recognize cellular changes characteristic of what?

a. carcinoma of the cervix b. normal, dysplastic, and malignant cells c. carcinoma in situ

a. What technique can rapidly and quantitatively measure several individual cell characteristics, such as membrane antigens and the DNA content of tumor cells b. this technique allows for identification and classification of tumors arising from what kind of cells

a. Flow cytometry b. T lymphocytes B lymphocytes mononuclear-phagocytic cells

FISH is used for?

detection of leukemias and lymphomas associated with specific translocations