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PP personal > Neoplasia - 5 > Flashcards

Neoplasia - 5 Flashcards

1
Q

Aflatoxin (aspergillus)
Means of exposure/sources
Assoc. cancers

A

Maize and peanuts

Hepatocellular carcinoma

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2
Q

Arsenic
Means of exposure/sources
Assoc. cancers

A

Herbicides, vineyard workers, fungicides

Lung cancer, liver angiosarcoma

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3
Q

Benzene
Means of exposure/sources
Assoc. cancers

A

Component of light oil, used in printing

Acute leukemia, Hodgkin lymphoma

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4
Q

Beryllium
Means of exposure/sources
Assoc. cancers

A

Space industry materials

Bronchogenic carcinoma

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5
Q

Cyclophosphamide and alanine
Means of exposure/sources
Assoc. cancers

A

Chemotherapy agent

Trans. cell carcinoma of urinary bladder

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6
Q

beta-napthylamine (aniline dyes)
Means of exposure/sources
Assoc. cancers

A

Worker in rubber, textile and printing industry

Trans. cell carcinoma of urinary bladder

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7
Q

Polycyclic hydrocarbons
Means of exposure/sources
Assoc. cancers

A

Chimney sweeper, fish or meats charbroiled on open flame

Squamous cell carcinoma, Adenocarcinoma of distal esophagus

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8
Q

Radon
Means of exposure/sources
Assoc. cancers

A

By product of uranium decay, and in underground mines

Bronchogenic carcinoma

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9
Q

HTLV-1
Mechanism
Assoc. cancers

A

Activates TAX gene

T cell leukemia and lymphoma

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10
Q

EBV
Mechanism
Assoc. cancers

A

Promotes polyclonal B cell prolif. increase risk for t(8;14)

Burkitt’s lymphoma, nasopharyngeal carcinoma

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11
Q

HBV
Mechanism
Assoc. cancers

A

Activates proto oncogenes, inactivates p53

Hepatocellular carcinoma

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12
Q

HHV-8
Mechanism
Assoc. cancers

A

Acts via cytokines released from HIV and HSV

Kaposi sarcoma

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13
Q

HPV 16 and 18
Mechanism
Assoc. cancers

A

16 - E6 inhibits p53; 18 - E7 inhibits RB1

SCC of vulva, vagina, anus, larynx and oropharynx

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14
Q

Bacteria that produces adenocarcinoma and low-grade malignant lymphoma of the stomach

A

H. pylori

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15
Q

Parasite that produces SCC of the urinary bladder

A

Schistosoma

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16
Q

Parasite that produces cholangiocarcinoma of bile ducts

A

Clonorchis sinensis and Opisthorchis

17
Q

replacement of normal bone marrow by malignant cells and/or fibrosis

A

Myelophthisic anemia

18
Q

(IgM) cold agglutinins associated with chronic lymphocytic leukemia (CLL) and certain types of malignant lymphoma

A

Cold autoimmune hemolytic anemia (AIHA)

19
Q

a. Activation of this pathway causes degradation of myosin heavy chains in skeletal muscle.
b. what activates it

A

a. ubiquitin proteasome pathway

b. PIF

20
Q

LMF functions

A
  1. Activates hormone-sensitive lipase (HSL) in adipose cells
  2. Increases release of TNF from macrophages and monocytes. TNF suppresses the appetite center in the hypothalamus, which leads to weight loss. TNF stimulates apoptosis

PP personal (13 decks)

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