Cancer Immunotherapy 1.2 Flashcards

1
Q

MOA of Imatinib

A

targets Abl group of tyrosine kinase

First drug to specifically target cancer cells rather than kill all rapidly dividing cells

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2
Q

Uses of Imatinib

A

CML Tx:
1st line Rx. in chronic phase CML - blast crisis
2nd line Rx. in chronic phase CML - not responding to interferon-α therapy

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3
Q

List kinase inhibitors of EGFR (2)

A

Gefitinib

Erlotinib

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4
Q

MOA of kinase inhibitors of EGFR

A

Binds to active domain of tyrosine kinase of EGFR = inhibition of signal pathway

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5
Q

Uses of kinase inhibitors of EGFR (2)

A

NSC lung cancer /pancreatic cancer

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6
Q

List multiple receptor kinase inhibitors (3)

A

Sorafenib
Sunitinib
Pazopanib

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7
Q

MOA of multiple receptor kinase inhibitors

Uses of multiple receptor kinase inhibitors

A

MOA: inhibit Multiple Receptor Tyrosine Kinase, including VEGFR, PDGFR

Uses: advanced renal cancer

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8
Q

Monoclonal antibody against HER2 receptor

What is it used to treat?

A

Trastuzumab

Tx: HER2 receptor positive breast cancer

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9
Q
MABs:
EGFR antagonists (2)

Angiogenesis inhibitors – VEGF inhibitor (2)

A

EGFR antagonists:
Cetuximab
Trastuzumab
Panitumumab (?)

VEGF inhibitors:
Bevacizumab
Ranibizumab

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10
Q

Uses of VEGF inhibitors

A

Prevent metastasis, retinopathy (ARMD), RCC, NSCLC, Cx, Ovarian ca. Colon ca.

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11
Q

Uses of EGFR antagonists

A

colorectal cancer

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