Cancer Immunotherapy 1.2

Question 1

MOA of Imatinib

Answer 1

targets Abl group of tyrosine kinase

First drug to specifically target cancer cells rather than kill all rapidly dividing cells

Question 2

Uses of Imatinib

Answer 2

CML Tx:
1st line Rx. in chronic phase CML - blast crisis
2nd line Rx. in chronic phase CML - not responding to interferon-α therapy

Question 3

List kinase inhibitors of EGFR (2)

Answer 3

Gefitinib

Erlotinib

Question 4

MOA of kinase inhibitors of EGFR

Answer 4

Binds to active domain of tyrosine kinase of EGFR = inhibition of signal pathway

Question 5

Uses of kinase inhibitors of EGFR (2)

Answer 5

NSC lung cancer /pancreatic cancer

Question 6

List multiple receptor kinase inhibitors (3)

Answer 6

Sorafenib
Sunitinib
Pazopanib

Question 7

MOA of multiple receptor kinase inhibitors

Uses of multiple receptor kinase inhibitors

Answer 7

MOA: inhibit Multiple Receptor Tyrosine Kinase, including VEGFR, PDGFR

Uses: advanced renal cancer

Question 8

Monoclonal antibody against HER2 receptor

What is it used to treat?

Answer 8

Trastuzumab

Tx: HER2 receptor positive breast cancer

Question 9

MABs:
EGFR antagonists (2)

Angiogenesis inhibitors – VEGF inhibitor (2)

Answer 9

EGFR antagonists:
Cetuximab
Trastuzumab
Panitumumab (?)

VEGF inhibitors:
Bevacizumab
Ranibizumab

Question 10

Uses of VEGF inhibitors

Answer 10

Prevent metastasis, retinopathy (ARMD), RCC, NSCLC, Cx, Ovarian ca. Colon ca.

Question 11

Uses of EGFR antagonists

Answer 11

colorectal cancer