Cancer Immunotherapy 1.2 Flashcards
MOA of Imatinib
targets Abl group of tyrosine kinase
First drug to specifically target cancer cells rather than kill all rapidly dividing cells
Uses of Imatinib
CML Tx:
1st line Rx. in chronic phase CML - blast crisis
2nd line Rx. in chronic phase CML - not responding to interferon-α therapy
List kinase inhibitors of EGFR (2)
Gefitinib
Erlotinib
MOA of kinase inhibitors of EGFR
Binds to active domain of tyrosine kinase of EGFR = inhibition of signal pathway
Uses of kinase inhibitors of EGFR (2)
NSC lung cancer /pancreatic cancer
List multiple receptor kinase inhibitors (3)
Sorafenib
Sunitinib
Pazopanib
MOA of multiple receptor kinase inhibitors
Uses of multiple receptor kinase inhibitors
MOA: inhibit Multiple Receptor Tyrosine Kinase, including VEGFR, PDGFR
Uses: advanced renal cancer
Monoclonal antibody against HER2 receptor
What is it used to treat?
Trastuzumab
Tx: HER2 receptor positive breast cancer
MABs: EGFR antagonists (2)
Angiogenesis inhibitors – VEGF inhibitor (2)
EGFR antagonists:
Cetuximab
Trastuzumab
Panitumumab (?)
VEGF inhibitors:
Bevacizumab
Ranibizumab
Uses of VEGF inhibitors
Prevent metastasis, retinopathy (ARMD), RCC, NSCLC, Cx, Ovarian ca. Colon ca.
Uses of EGFR antagonists
colorectal cancer