Neoplasia Flashcards

1
Q

Define malignant neoplasm

A

Abnormal growth of cells that persists after the initial stimulus has been removed and invades surrounding tissue with potential to spread to distant sites

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2
Q

Define tumour

A

An umbrella term for any type of lump or swelling

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3
Q

Is dysplasia reversible?

A

Yes

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4
Q

Is metaplasia reversible?

A

Yes

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5
Q

Is neoplasia reversible?

A

No

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6
Q

What, in reference to neoplasia, is a primary site?

A

The original location of the neoplasm

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7
Q

What, in reference to neoplasia, is a secondary site?

A

Where the neoplasm has spread to

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8
Q

Define metastasis

A

Malignant neoplasm that has spread to new non-contiguous sites from its original

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9
Q

Do benign neoplasms spread?

A

No

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10
Q

Define some characteristics of benign neoplasms

A

Don’t spread, remain confined to site of origin, will continue to grow unless removed, may be asymptomatic

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11
Q

List some characteristics of malignant neoplasms

A

Have the POTENTIAL to metastise (doesn’t mean they will)

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12
Q

Define neoplasm

A

Abnormal growth of cels that persists after the initial stimulus is removed

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13
Q

in which gender are teratomas malignant or benign?

A

Benign- women. Malignant- men.

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14
Q

Why are teratomas more likely to be malignant in men?

A

The testes are less well differentiated compared to teratomas present in the ovaries

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15
Q

What are blastomas?

A

Malignancy of precursor cells, more common in children eg retinoblastoma, nephroblastoma

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16
Q

What are blastomas?

A

Malignancy of precursor cells, more common in children eg retinoblastoma, nephroblastoma

17
Q

What are the six hallmarks of of cancer?

A

Self-sufficiency in growth signals, resistance to growth stop signals, immortalisation, angiogenesis, resistance to apoptosis, ability to invade and produce metastases.

18
Q

Which cancers regularly metastasise to bone?

A

Breast carcinoma, bronchial carcinoma, renal carcinoma, prostate carcinoma, thyroid carcinoma

19
Q

What does the term ‘progression’ mean in terms of cancer?

A

Step-wise transition from normal cell to benign to malignant by the accumulation of multiple mutations.

20
Q

What is the most common type of cervical cancer?

A

Squamous cell carcinoma

21
Q

What screening programmes are available in england and wales?

A

Breast, cervical, bowel

22
Q

Which cancers produce PTH?

A

Breast carcinoma, bronchial squamous cell carcinoma, kidney, ovaries