Neoplasia

Question 1

Name two classifications and their subgroups.

Answer 1

Clinical: benign or malignant
Histological: epithelial or mesenchymal

Question 2

What are 5 features of a benign tumour?

Answer 2

Growth is slow
Growth is non invasive
Benign tumours do not spread
Do not recur when removed
Tumour margins are not well defined

Question 3

What are 5 features of a malignant tumour?

Answer 3

Growth is rapid
Growth is invasive - destroys tissues
Tumour spreads and metastasises
Recurrence after excision is very common
Tumour margins are well defined

Question 4

Name 2 benign tumours and their tissue of origin.

Answer 4

Chondroma - cartilage

Lipoma - fat tissue

Question 5

Name 2 malignant tumours and their tissue of origin.

Answer 5

Carcinoma: epithelial cells
Lymphoma: blood cell tumours that develop from lymphatic cells (lymphoid tissue)

Question 6

Give an example of a cancer and its commonest site of metastasis.

Answer 6

Colon cancer metastasises to liver

Lung cancer metastasises to brain

Question 7

What are the three main routes of metastatic spread?

Answer 7

Lymphatic
Haematogenous
Transcoelomic

Question 8

List the seven steps involved from the primary tumour to the establishment of a secondary tumour.

Answer 8

intravasation
survival in the circulation
arrest in organ
extravasation
survival of cells after extravasation
initial growth of cells after extravasation
persistence of growth