Local Anaesthetic Flashcards

0
Q

Which structures enter the mandible at the mandibular foramen?

A

inferior alveolar nerve and vessels

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1
Q

Where is LA deposited during an IAN block?

A

Deposited around the nerve trunk

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2
Q

Give examples of a local anaesthetic.

A

Lidocaine, prilocaine, articaine (amides)
cocaine, procaine (esters)

Lidocaine + 1:80,000 epinephrine
Prilocaine + felypressin

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3
Q

What are the advantages of using a vasoconstrictor?

A

Vasoconstrictor constricts blood vessels. Most LA are vasodilators and increased blood flow will increase the ‘wash-out’ of LA. Vasoconstrictors therefore increase the duration of action.

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4
Q

Give examples of a vasoconstrictor.

A

Epinephrine (adrenaline)

Felypressin (prilocaine)

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5
Q

What is the pterygomandibular raphe?

A

Ligamentous (fibrous) band attached to the hamulus of the medial pterygoid muscle and the mylohyoid line of the mandible. Lies between the superior constrictor and buccinator muscles.

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6
Q

Where in the mouth is this situated and how is it recognised?

A

Situated posteriorly the last standing tooth and is recognised by stretching the cheek and palpating the coronoid notch.

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7
Q

Sometimes the advancing needle may encounter the lingula of the mandible. What is this?

A

Prominent bony ridge at the entrance to the mandibular canal (margin of the mandibular foramen), that attaches the sphenomandibular ligament.

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8
Q

Before injecting, the dentist allows the plunger to retract slightly. Why is this done?

A

To aspirate - this ensures the needle is not within a blood vessel.

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9
Q

When the anaesthetic is injected, the tip of the needle will lie in the pterygomandibular space. Between which part of the mandible and which muscle does this lie?

A

Between the ramus of the mandible and the medial pterygoid muscle.

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10
Q

The dentist may also infiltrate LA into mucosa on the buccal side of the tooth. Which sensory nerve supplies this region?

A

Buccal nerve

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11
Q

Why is no infiltration of the gingivae necessary on the lingual side?

A

The lingual nerve (which supplies this area) branches from the mandibular nerve anteriorly to the inferior alveolar nerve - it is often anaesthetised at the same time as the IAN during the nerve block.

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12
Q

Once the LA has been administered, the dentist waits a few minutes for the IAN block to work. What clinical sign indicates that the anaesthetic has been effective?

A

Numbness of the lower lip and chin - patient cannot feel pain when this is squeezed but can still feel pressure.

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13
Q

What is the anatomical basis of this sign?

A

The mental nerve (which supplies sensation to the lower lip) is a branch from the inferior alveolar nerve, therefore will be anaesthetised too.

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14
Q

In this patient, however, the anaesthetic does not work as planned. Instead, the corner of the patients mouth starts to droop. What has happened?

A

Facial palsy - the needle has penetrated the parotid gland and anaesthetic has been injected into this, causing paralysis of the facial nerve.

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15
Q

What would be your immediate concern?

A

To protect the patient’s eye - they can no longer blink, therefore there is a risk of the cornea drying out, or dirt getting into the eye - an eye patch must be worn to protect it.

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16
Q

What clinical test would you carry out to check this danger?

A

Ask the patient to blink and check if they have full control over blink reflex.

17
Q

Where is LA administered during infiltration?

A

Around the terminal branches of nerves

18
Q

Where is the needle placed in relation to the apex of the tooth?

A

Over the apex of the tooth at the mucobuccal fold and slightly distal.

19
Q

What branch of the trigeminal nerve innervates the maxilla?

A

The maxillary branch (V2) - which branches into superior alveolar nerve, which branches into posterior superior, middle superior and anterior superior alveolar nerves.

20
Q

What anaesthetics are esters? How are these broken down in the body?

A

Benzocaine, cocaine - broken down by tissue esterases and action is quite brief.

21
Q

What anaesthetics are amides? How are these broken down in the body?

A

Lignocaine, articaine, prilocaine - broken down by liver amidases and have a longer duration than esters.

22
Q

What are examples of preservatives used in local anaesthetics?

A

Bisulphite

Propylparaben

23
Q

What is infiltration used for?

A

Used to anaesthetise soft tissues and to produce pulpal anaesthesia where alveolar bone is thin (maxilla, lower anterior teeth)

24
Q

What are nerve blocks used for?

A

Used to produce soft tissue anaesthesia and used where bone is too thick to allow infiltration (mandible)

25
Q

What do you check for on the LA cartridge?

A

Batch number and expiry date

26
Q

Which needle lengths are used for each LA technique?

A

35mm needle used for IAN block

25mm needle used for infiltration

27
Q

When finished with LA syringe, where does each part go?

A

Needle/cartridge/syringe = sharps box
Bung = clinical waste
Plunger handle = dirty box for decontamination

28
Q

Where is a mental block administered?

A

Between apices of lower premolars

29
Q

What are the important landmarks for an IAN block?

A

Coronoid notch of the mandibular ramus, posterior border of mandible, pterygomandibular raphe, lower premolar teeth of the opposite side

30
Q

Describe the action potential sequence.

A

Membrane potential reaches threshold at -55mV - triggers action potential
Sodium M-gate opens: depolarisation, sodium ions diffuse into cell, potential increases rapidly and peaks at +35mV
Sodium H-gate closes and potassium voltage-gated channel opens: repolarisation, potassium ions diffuse out of cell, potential decreases rapidly
Voltage-gated potassium channels close: potential overshoots briefly, resting potential reinstated

31
Q

What is the function of the refractory period?

A

stops rapid firing

32
Q

During an action potential, when are the sodium M-gates and H-gates open or closed?

A

At rest: M-gate closed, H-gate open
When action potential is triggered: M-gate open, H-gate open
At action potential peak: M-gate open, H-gate closed
During the refractory period: M-gate open, H-gate closed
At rest: M-gate closed, H-gate open

33
Q

What are the 3 main components of a local anaesthetic molecule? What else does a LA solution contain?

A

hydrophobic aromatic end, ester/amide bond, hydrophilic amide side chain
LA molecule in hypochlorite solution, reducing agent (provides electrons), fungicides and preservatives (provides longer shelf life - possible allergies), vasoconstrictor

34
Q

What is trismus?

A

A possible complication of LA use. Onset within hours of IAN block. Occurs when injected too far down or when injected too quickly - damages the medial pterygoid muscle, therefore causing limited mouth opening.

36
Q

What are two alternative methods of administering an IAN block?

A
Gow Gates technique (where LA is administered at head of condyle, open mouth)
Akinosi technique (closed mouth, LA administered above lingula)
37
Q

What are the maximum doses for LA?

A
lidocaine = 4.4mg/kg
prilocaine = 6mg/kg
38
Q

Where is the pterygomandibular space?

A

Space that lies between the medial pterygoid muscle and the medial surface of the ramus of the mandible.

39
Q

What are the possible complications of LA?

A

trismus, facial palsy, fainting, intravascular injection

40
Q

What is the site of action of a local anaesthetic?

A

voltage gated sodium channels

41
Q

Which nerve fibres are anaesthetised by LA and in which order?

A

A delta (anaesthetised first)
C
A beta
A alpha (anaesthetised last)