Neonates Flashcards
Why is jaundice seen in over 50% of newborns
Increase in breakdown of RBC as high Hb at birth
Red blood cells have shorter lifespan in neonates
Hepatic metabolism less efficient
What is kernicterus
Bilirubin encephalopathy as free unconjugated bilirubin can cross the BBB
How can kernicterus present
Moderate cases
- lethargy and poor feeding
Severe cases
- irritability
- increased muscle tone (oplsthotonos)
- seizures and comas
What is oplsthonos
When babies lie with arched back
What are long term effects of kernicterus
Choreoathetoid cerebral palsy
Sensorineural deafness
Learning disabilities
Where does jaundice typically present in a newborn
The head and then spreads downwards with increasing severity
Cephalocaudal
Referral guidelines for neonates with jaundice
If first showed signs within 24 hrs of life then admit to neonatal or paeds unit within 2 hours
If over 24 hours admit within 6 hours if
- first appeared at more than 7 days
- very unwell
- gestational age less than 35 weeks
- prolonged jaundice
- issues about weight
- pale stools and dark urine
If neither of these
- get transcutaneous bilirubin level with 6 hours if not refer to hospital for bilirubin level in 6 hours
Investigations in secondary care for jaundiced baby
FBC and blood film
Blood group
DAT
LFTs
G6PD levels
Cultures of urine/blood to look for cause of sepsis
What determines prolonged jaundice in neonates
Gestational age of 37 or more = 14 days
Gestational age of less than 37= 21 days
Difference in solubility between unconjugated and conjugated bilirubin
Unconjugated- fat
Conjugated- water
How does phototherapy work on jaundice
Converts uBR to lumirubin and photobilirubin but DOES NOT WORK on Conjugated bilirubin
What is problem with transcutaneous bilirubin measurements
Only shows levels of unconjugated- if urgent then do blood reading which will show split between conjugated and unconjugated
Causes of jaundice in first 24 hours of life
Infection
ABO or Rh incompatibility
G6PD or HS
Gilberts
Cirgler-Najjar
Differences between Rhesus incompatibility and ABO
Rhesus negative mums produce ABs against Rhesus positive baby- normally does not affect first pregnancy only subsequent
ABO occurs in type O mums with naturally occuring Anti-A/B ABS- can occur in any pregnancy
Rhesus not very common but extremely serious
ABO more common but reduced morbidity/mortality
Rfx for haemolytic disease of the newborn
Chorionic villous sampling
Amniocentesis
Vaginal delivery
Antenatal haemorrhage
How to diagnose haemolytic disease of the newborn
Coombs test- will show positive indirect antiglobulin test showing IgG in maternal blood
Antibodies in ABO incompatibility
Anti-A haemolysin IgG- more common
Anti-B haemolysin IgG
What triggers gilberts to cause neonatal jaundice
Normally infection
What is Criger-Najjar syndrome
Results in a complete dysfunction of the gene encoding UDP-Glucuronyl transferase
Difference between Criger-Najjar syndrome and gilberts
CN results in a complete dysfunction of the gene encoding UDP-Glucuronyl transferase whereas gilberts get some activity
In CN the hyperbilirubinaemia is massive
Treatment options for acute bilirubin encephalopathy
Immediate exchange transfusion
Phototherapy
Hydration
IVIG
Folic acid after to prevent anaemia
Things to tell parent if baby undergoing phototherapy
Not harmful but eyes will be covered with blood samples taken regularly so know when to stop
Breastfeeding every 3 hours
Need to measure bilirubin after to check for rebound hyperbilirubinaemia
Options for treating neonatal jaundice
Phototherapy
Exchange transfusion
Thresholds for determining when to
Common causes of jaundice neonatal jaundice
Physiological
Breast milk jaundice
Sepsis
Feeding difficulty