Neisseria

Question 1

• gram negative, non motile diplococci
• fastidious
• aerobic, oxidase positive, catalase positive

Answer 1

neisseria gonorrhoeae

Question 2

• incubation 2-5 days
• men: restricted to urethra, purulent discharge
• women: purulent vaginal discharge, PID

Answer 2

neisseria gonorrhoeae

Question 3

disseminated neisseria gonorrhoeae?

Answer 3

fever, pustular erythematous rash, infection of joints

Question 4

neonatal neisseria gonorrhoeae?

Answer 4

infection during vaginal delivery, purulent conjunctivitis “opthalmia neonatorum”

Question 5

virulence factors of neisseria gonorrhoae?

Answer 5

• pili, attach to nonciliated cells
• opa proteins: clumping
• LOS: endotoxin, inflammation
• outer membrnae poteins
• trans/lactoferring, hemoglobin binding proteins
• IgA protease

Question 6

lab diagnosis of neisseria gonorrhoeae ?

Answer 6

• swabs, blood, urine
• gram stain: PMN intracellular gram negative diplococci
• culture on selective Thayer-Martin media

Question 7

drug of choice for neisseria gonorrhoeae ?

Answer 7

ceftriaxone + azithromycin, neonatal prophylaxis with 1% silver nitrate

Question 8

• common cause of CA bacterial meningitis

- transmitted by exchange of respiratory and throat secretions

Answer 8

neisseria meningitidis

Question 9

• 3 to 7 days post exposure, starts with severe headache

- rapid development: sudden high fever, nuchal rigidity, altered mental status

Answer 9

meningococcal meningitis

Question 10

• 20% of meningitis cases develop septicemia
• symptoms: fatigue, vomiting, chills, severe myalgia, tachypnea
• petechial lesions, hemorrhagic bullae, gangrene
• DIC

Answer 10

meningococcemia

Question 11

drug of choice for neisseria meningitis?

Answer 11

• ceftriaxone, cefotaxime

- rifampin prophylaxis

Question 12

diagnosis of neisseria meningitidis?

Answer 12

lumbar puncture and gram stain/culture

Question 13

Hib-MenCY vaccine given?

MenACWY vaccine given?

Answer 13

6wks-18months

11-12 yrs, booster at 16

Question 14

recombinant multicomponent vaccine contains serogroup ____

Answer 14

B

Question 15

• human bite wounds and fist fights
• pitting of agar
• resistant to empirical bite wound antibiotics

Answer 15

eikenella corrodens

Question 16

a. actinomycetemcomitans
- periodontitis
- endocarditis
- bite wound infections
- opportunistic infections
- star like culture
- DOCs: cephalosporins, tetracyclines

Answer 16

aggergatibacter

Question 17

• spreads through minor oral trauma
• bacteremia in infants, osteomyelitis, endocarditis
• gram negative pleomorphic rod, hemolytic

Answer 17

kingella kingae