Natural Products

Question 1

What is the MOA of vinca alkaloids and what phase of the cell cycle do they affect?

Answer 1

Inhibit tubular polymerization

M phase

Question 2

What is the adverse effect of vinblastine and what 3 cancers does it treat?

Answer 2

Severe blisters

HL, NHL, and breast cancer

Question 3

Adverse effect of vincristine and what 3 categories of cancers does it treat?

Answer 3

SIADH
CLL
Hematologic cancers
Pediatric tumors

Question 4

3 cancers we use vinorelbine to treat?

Answer 4

NSCLC, breast and ovarian

Question 5

MOA for taxanes and antibicrotubules and what phase of the cell cycle does it affect?

Answer 5

Enhance tubule polymerization which inhibits m phase

Question 6

What category of tumors do we use paclitaxel for and name 3 specific?

Answer 6

Broad range of solid tumors.

Breast, ovary, and lung

Question 7

Docetaxel is approved for use in what 2 cancers and is what line of therapy in those cancers?

Answer 7

Second line therapy in breast and NSCLC

Question 8

What is the unique use for cabazitaxel and why?

Answer 8

Poor substrate for PGP so this is helpful in multi drug resistant tumors

Question 9

MOA of Ipabexilone and eribulin, what type of tumors can these guys go after, and what is one cancer they are both approved for?

Answer 9

B analog, so inhibits microtubule function
Less sensitive to PGP so if a tumor overexpresses PGP, this is good
Metastatic breast cancer

Question 10

MOA of etoposide and 4 cancers it is used against?

Answer 10

Topoisomerase 2 blocker

Germ cell, lung, HL and NHL

Question 11

MOA for topotecan and 2 cancers to treat with it?

Answer 11

Topo 1 blocker

Second line therapy for ovarian and small cell lung cancer

Question 12

MOA for irinotecan and 1 cancer to treat with it?

Answer 12

Topo 1 blocker

Adenocarcinoma of the pancreas. Use with 5FU

Question 13

What two MOAs am I thinking about with natural cancer drugs?

Answer 13

Either inhibit of enhance microtubules

Inhibit topo 1 and 2