HP Growth Factors - Pharm Flashcards
What do we give filgrastim for and how do we need to make sure to administer it?
What are two adverse effects with this med?
Give it fo low neutrophils because it is a GCSF
Don’t give it during chemo because the chemo will take it out.
Allergic reaction and bone pain
What is the difference between pegfilgrastim and filgastrim?
Filgastrim has a longer half life
What do we give sargramostim for and what are 2 adverse effects?
Boost granulocytes and macrophages/monocytes because it is a GMCSF.
Gasping syndrome in premature babes
Fluid retention, so edema, effusions etc.
Why is filgrastim used more than sargramostim?
Less side effects and quicker recovery from neutropenia
What is the clinical application of using plerixafor, what two patient populations do we use it in and what is the one adverse effect we are concerned about?
Mobilizing blood stem cells to the bone marrow if GCSF ain’t working
MM and lymphoma
Hyerpsentivity rxn
What is the MOA of oprelvekin, what is the clinical application and what are the 4 adverse effects?
It is IL11 so promotes maturation of megakaryocytes.
Treats thrombocytopenia in patients undergoing myelosuppresive chemo
Severe edema, cardiac dysrhythmias, allergic reactions, and bloodshot eyes.
What is the clinical effect and application of romiplostim? What is the mechism it works through?
Increase platelet count in patients who have ITP
The TPO receptor
What is the MOA of eltrombopag, clinical effect and 2 clinical applications?
TPO agonist
Raised platelet counts
ITP and hepatitis C
2 families of drugs causing hemolytic anemia, give examples of each?
Cephalosporins, most common cause, ceftriaxone and cefotetan
Penacillins, piperacillin.
3 top drugs causing drug induced thrombocytopenia?
Heparin most common
Quinidine and quinine
3 drugs/toxins causing aplastic anemia?
Chemo (alkylating agents), chlorampheicol (antibiotic), and benzene
