Growth Factor Receptor Blockers Flashcards
What two growth factors are we going after with these blockers?
Epidermal growth factor receptor
Vascular endothelial growth factor
MOA for cetuximab, adverse effect, 2 cancers to treat and one black box warning?
Antibody against EGFR with the RAS mutaiton
Combo with irinotecan and oxaliplatin to treat colon colorectal cancer
Combo with radiation to treat local head and neck cancer
Acneiform skin rash
Death from the combo radiation to treat head and neck cancer
MOA of panitumumab, what cancer does it treat as part of what regimen?
antibody against EGFR with wild type RAS
Colorectal cancer in the FOLFOX regimen oxaliplatin 5FU and folinic acid
MOA and cancer to treat for necitumumab?
Antibody against EGFR
NSCLC
MOA for erlotinib and what 2 cancers to treat?
EGFR blocker
NSCLC and pancreatic cancer
What cancer is afatinib used for?
First line treatment for EGFR mutated NSCLC
What cancer does Osimertinib treat?
EGFR T790M mutant NSCLC
What are two unique adverse effects of Osimertinib?
Qt prolongation and cardiomyopathy
MOA for bevacizumab and what 3 cancers to treat?
Antibody against VEGF
Colorectal, NSCLC and breast
MOA for zig-afilbercept and what cancer to treat?
VEGF
Colorectal
MOA for ramucirumab and what 3 cancers is it used for?
Antibody against VEGF receptor
Gastric adenocarcinoma, colorectal, and NSCLC
MOA, What syndrome is found in patients taking sorafenib and what 2 cancers is it used in?
Inhibits multiple RTKs
Hand foot syndrome
Renal cell carcinoma and hepatocellular
MOA of sunitinib, adverse effect, and cancer to treat?
Inhibits multiple RTKs
Cardiac dysfunction
Real cell carcinoma
MOA of pazopanib and what cancer to treat?
Inhibits multiple RTKs
Renal cell cancer
