Antitumor Antibiotics

Question 1

What are the most widely used anti tumor antibiotics, what is their MOA, and what is a big time toxicity?

Answer 1

Anthracyclines
Inhibit topo 2
Cardiotoxicity

Question 2

What is one of the most important chemo drugs in clinical practice, how is it used and what can it treat?

Answer 2

Doxorubicin
In conjunction with cyclo, cisplatin and 5FU
Everything

Question 3

What cancer do we use daunorubicin for?

Answer 3

AML

Question 4

What does idarubibin treat and what do we need to combine it with?

Answer 4

AML with cytarabine

Question 5

What cancer does epirubicin treat?

Answer 5

Breast cancer

Question 6

Unique adverse effect of mitoxantrone and what 2 cancers does it treat?

Answer 6

Blue fingernails, sclera and urine

Prostate and NHL

Question 7

What is the MOA of dexrazoxane and what cancer is it used for?

Answer 7

Iron cheating agent

Used in women with metastatic breast cancer to reduce or prevent cardio toxicity

Question 8

MOA of mitomycin, it is the best available drug in combo with what to treat what kind of tumors, what is a special indication of it?

Answer 8

Causes DNA cross linking
Combo it with radiation to treat hypoxic tumors
Intravesical treatment of bladder cancer

Question 9

MOA of bleomycin, what is the big time toxicity, and 2 tumors to remember it treats?

Answer 9

Single and double DNA breaker
Pulmonary
NHL and HL

Question 10

3 MOA I am thinking with anti tumor antibiotics?

Answer 10

Inhibit topo 2
Form DNA cross linking
Single and double strand breaking

Question 11

3 mechanisms of resistance for anti-tumor antibiotics?

Answer 11

Point mutations in topo 2
Efflux pumps
Bleomycin hydroplane enzyme