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Pharma Pearls > Natural Product Anticancer Drugs > Flashcards

Natural Product Anticancer Drugs Flashcards

0
Q

Testicular CA, kaposi sarcoma

Bone marrow suppression

A

VinBlastine

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1
Q

Prevents microtubule assembly. Causes cell arrest at metaphase. Cell cycle specific.

Acute leukemias

SE: peripheral neurotpathy

A

Vincristine

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2
Q

Podophyllotoxin
Inhibits DNA topoisomerase II. Inhibits mitochondrial electron transport. Cell cycle specific.

Treatment of lung cancer, NHL and GTN

A

Etoposide

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3
Q

Campothecin.
Inhibits topoisomerase I. Cell cycle specific.

Treatment of small cell lung CA

A

Topotecan

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4
Q

Taxane.
Interferes with mitotic spindle. Prevents microtubule disassembly into tubulin monomers. Cell cycle specific.

Advanced breast and ovarian cancers

A

Paclitaxel

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Pharma Pearls (10 decks)

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