Antmetabolites

Question 0

Inihibits dihydrofolate reductase. Decreases synthesis of thymidylate, amino a ids, purine nucleotides. Cell cycle specific.

Treatment of lymphomas and GTN

SE: myelosuppression, pulmonary fibrosis

Rescue agent: Leucovorin(folinic acid)

Answer 0

Methotrexate

Question 1

Inhibits de novo purine nucleotide synthesis. Activated by HGPRT. Cell cycle specific.

Treatment of acute leukemias

SE: myelosuppression, hepatotoxicity

Metabolism inhibited by allopurinol

Answer 1

6-Mercaptopurine

Question 2

Inhibits thymidylate synthase. Causes thyminless deatho f cells. Cell cycle specific.

Treatment of colorectal and skin cancer,

SE: myelosuppression

Answer 2

5-Fluorouracil

Question 3

Inhibits DNA synthesis and repair. Inhibits ribonucleotide reductase with reduced formation of dNTPs. Cell cylce specific.

Treatment of CML in blast crisis. Most specific for the S phase of the cell cycle

Answer 3

Cytarabine

Question 4

Inhibits ribonucleotide reductase, treatment of pancreatic cancer

Answer 4

Gemcitabine